Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared
OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine. METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up wit...
Gespeichert in:
| Veröffentlicht in: | European journal of gastroenterology & hepatology 1996-03, Vol.8 (3), p.219-224 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 224 |
|---|---|
| container_issue | 3 |
| container_start_page | 219 |
| container_title | European journal of gastroenterology & hepatology |
| container_volume | 8 |
| creator | Uil, Jan J van Elburg, Ruurd M van Overbeek, Femke M Meyer, Jos W Mulder, Chris J Heymans, Hugo S |
| description | OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine.
METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT, a solution of lactulose (L) and mannitol (M) was given to the fasting patient and the L-M ratio calculated in a 5-hour urine sample by gas chromatographyratios >0.089 are considered abnormal. The solution was made hyperosmolar by adding sucrose (1560 mmol/l).
RESULTS:The L-M ratio was 2–3 times higher at diagnosis than either at 8 months to 2 years gluten free, or beyond 2 years gluten free, consecutively. The L-M ratio (mean, range) was significantly higher in cases of biopsies with (sub)total villous atrophy (VA) (0.388, 0.062–0.804, n = 28), partial VA (0.240, 0.062–0.841, n=18) and villous irregularity (0.143, 0.017–0.322, n = 29) than in case of normalized histology after GFD (0.085, 0.021–0.230, n = 19). The rate of normalization of functional integrity was slower in adults than in children, demonstrated by a combination of histology and SAT.
CONCLUSION:The SAT correlates well with the degree of VA. It is important for daily clinical practice that the simple and non-invasive SAT can be used as an indicator of intestinal damage, thus influencing need for and timing of intestinal biopsies. |
| doi_str_mv | 10.1097/00042737-199603000-00006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78204075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78204075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3296-e1770d090a6934df1bfbc7af30923e16cff6b571dc275491d8a526666473a7863</originalsourceid><addsrcrecordid>eNp1kU9vFCEYh4mxade2H8GEg_E29mWYgaE301g1aeLFJl4MeYcBi7LDCEw2fntZd91bSQiQ9_nx54EQyuAdAyVvAKBrJZcNU0oAr8umdhAvyIZ1kje9GORLsgHVd41Q7NsFeZXzTwAmOZPn5HyQbQctbMj3-xhC3DXrQqOjJVksdqIm2uDR0AWLt3PJtzSvPzBRHHNMS_FxpsXmQnGeqJ_3Uz9joKOPS_Y21_x2wWSnK3LmMGR7fRwvyeP9h693n5qHLx8_371_aAxvlWgskxImUIBC8W5ybHSjkeg4qJZbJoxzYuwlm0wr-06xacC-FbXVp6IcBL8kbw_7Lin-Xut19NZnY0PA2cY1azm00IHsKzgcQJNizsk6vSS_xfRHM9B7s_q_WX0yq_-ZrdHXxzPWcWunU_CostbfHOuYDQaXcDY-nzAOA1d8j3UHbBdDsSn_CuvOJv1kMZQn_dy_8r_AHpBn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78204075</pqid></control><display><type>article</type><title>Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Uil, Jan J ; van Elburg, Ruurd M ; van Overbeek, Femke M ; Meyer, Jos W ; Mulder, Chris J ; Heymans, Hugo S</creator><creatorcontrib>Uil, Jan J ; van Elburg, Ruurd M ; van Overbeek, Femke M ; Meyer, Jos W ; Mulder, Chris J ; Heymans, Hugo S</creatorcontrib><description>OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine.
METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT, a solution of lactulose (L) and mannitol (M) was given to the fasting patient and the L-M ratio calculated in a 5-hour urine sample by gas chromatographyratios >0.089 are considered abnormal. The solution was made hyperosmolar by adding sucrose (1560 mmol/l).
RESULTS:The L-M ratio was 2–3 times higher at diagnosis than either at 8 months to 2 years gluten free, or beyond 2 years gluten free, consecutively. The L-M ratio (mean, range) was significantly higher in cases of biopsies with (sub)total villous atrophy (VA) (0.388, 0.062–0.804, n = 28), partial VA (0.240, 0.062–0.841, n=18) and villous irregularity (0.143, 0.017–0.322, n = 29) than in case of normalized histology after GFD (0.085, 0.021–0.230, n = 19). The rate of normalization of functional integrity was slower in adults than in children, demonstrated by a combination of histology and SAT.
CONCLUSION:The SAT correlates well with the degree of VA. It is important for daily clinical practice that the simple and non-invasive SAT can be used as an indicator of intestinal damage, thus influencing need for and timing of intestinal biopsies.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-199603000-00006</identifier><identifier>PMID: 8724020</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Atrophy ; Biological and medical sciences ; Biopsy ; Celiac Disease - diet therapy ; Celiac Disease - metabolism ; Celiac Disease - pathology ; Child ; Child, Preschool ; Chromatography, Gas ; Fasting ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Agents - pharmacokinetics ; Gastrointestinal Agents - urine ; Glutens ; Humans ; Infant ; Intestinal Absorption ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Intestine, Small - metabolism ; Intestine, Small - pathology ; Lactulose - pharmacokinetics ; Lactulose - urine ; Male ; Mannitol - pharmacokinetics ; Mannitol - urine ; Medical sciences ; Middle Aged ; Osmolar Concentration ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Sucrose - pharmacokinetics</subject><ispartof>European journal of gastroenterology & hepatology, 1996-03, Vol.8 (3), p.219-224</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3083930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8724020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uil, Jan J</creatorcontrib><creatorcontrib>van Elburg, Ruurd M</creatorcontrib><creatorcontrib>van Overbeek, Femke M</creatorcontrib><creatorcontrib>Meyer, Jos W</creatorcontrib><creatorcontrib>Mulder, Chris J</creatorcontrib><creatorcontrib>Heymans, Hugo S</creatorcontrib><title>Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine.
METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT, a solution of lactulose (L) and mannitol (M) was given to the fasting patient and the L-M ratio calculated in a 5-hour urine sample by gas chromatographyratios >0.089 are considered abnormal. The solution was made hyperosmolar by adding sucrose (1560 mmol/l).
RESULTS:The L-M ratio was 2–3 times higher at diagnosis than either at 8 months to 2 years gluten free, or beyond 2 years gluten free, consecutively. The L-M ratio (mean, range) was significantly higher in cases of biopsies with (sub)total villous atrophy (VA) (0.388, 0.062–0.804, n = 28), partial VA (0.240, 0.062–0.841, n=18) and villous irregularity (0.143, 0.017–0.322, n = 29) than in case of normalized histology after GFD (0.085, 0.021–0.230, n = 19). The rate of normalization of functional integrity was slower in adults than in children, demonstrated by a combination of histology and SAT.
CONCLUSION:The SAT correlates well with the degree of VA. It is important for daily clinical practice that the simple and non-invasive SAT can be used as an indicator of intestinal damage, thus influencing need for and timing of intestinal biopsies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Celiac Disease - diet therapy</subject><subject>Celiac Disease - metabolism</subject><subject>Celiac Disease - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, Gas</subject><subject>Fasting</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Agents - pharmacokinetics</subject><subject>Gastrointestinal Agents - urine</subject><subject>Glutens</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestine, Small - metabolism</subject><subject>Intestine, Small - pathology</subject><subject>Lactulose - pharmacokinetics</subject><subject>Lactulose - urine</subject><subject>Male</subject><subject>Mannitol - pharmacokinetics</subject><subject>Mannitol - urine</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osmolar Concentration</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Sucrose - pharmacokinetics</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9vFCEYh4mxade2H8GEg_E29mWYgaE301g1aeLFJl4MeYcBi7LDCEw2fntZd91bSQiQ9_nx54EQyuAdAyVvAKBrJZcNU0oAr8umdhAvyIZ1kje9GORLsgHVd41Q7NsFeZXzTwAmOZPn5HyQbQctbMj3-xhC3DXrQqOjJVksdqIm2uDR0AWLt3PJtzSvPzBRHHNMS_FxpsXmQnGeqJ_3Uz9joKOPS_Y21_x2wWSnK3LmMGR7fRwvyeP9h693n5qHLx8_371_aAxvlWgskxImUIBC8W5ybHSjkeg4qJZbJoxzYuwlm0wr-06xacC-FbXVp6IcBL8kbw_7Lin-Xut19NZnY0PA2cY1azm00IHsKzgcQJNizsk6vSS_xfRHM9B7s_q_WX0yq_-ZrdHXxzPWcWunU_CostbfHOuYDQaXcDY-nzAOA1d8j3UHbBdDsSn_CuvOJv1kMZQn_dy_8r_AHpBn</recordid><startdate>199603</startdate><enddate>199603</enddate><creator>Uil, Jan J</creator><creator>van Elburg, Ruurd M</creator><creator>van Overbeek, Femke M</creator><creator>Meyer, Jos W</creator><creator>Mulder, Chris J</creator><creator>Heymans, Hugo S</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199603</creationdate><title>Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared</title><author>Uil, Jan J ; van Elburg, Ruurd M ; van Overbeek, Femke M ; Meyer, Jos W ; Mulder, Chris J ; Heymans, Hugo S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3296-e1770d090a6934df1bfbc7af30923e16cff6b571dc275491d8a526666473a7863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Celiac Disease - diet therapy</topic><topic>Celiac Disease - metabolism</topic><topic>Celiac Disease - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, Gas</topic><topic>Fasting</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Agents - pharmacokinetics</topic><topic>Gastrointestinal Agents - urine</topic><topic>Glutens</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestine, Small - metabolism</topic><topic>Intestine, Small - pathology</topic><topic>Lactulose - pharmacokinetics</topic><topic>Lactulose - urine</topic><topic>Male</topic><topic>Mannitol - pharmacokinetics</topic><topic>Mannitol - urine</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osmolar Concentration</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Sucrose - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uil, Jan J</creatorcontrib><creatorcontrib>van Elburg, Ruurd M</creatorcontrib><creatorcontrib>van Overbeek, Femke M</creatorcontrib><creatorcontrib>Meyer, Jos W</creatorcontrib><creatorcontrib>Mulder, Chris J</creatorcontrib><creatorcontrib>Heymans, Hugo S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uil, Jan J</au><au>van Elburg, Ruurd M</au><au>van Overbeek, Femke M</au><au>Meyer, Jos W</au><au>Mulder, Chris J</au><au>Heymans, Hugo S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>1996-03</date><risdate>1996</risdate><volume>8</volume><issue>3</issue><spage>219</spage><epage>224</epage><pages>219-224</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine.
METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT, a solution of lactulose (L) and mannitol (M) was given to the fasting patient and the L-M ratio calculated in a 5-hour urine sample by gas chromatographyratios >0.089 are considered abnormal. The solution was made hyperosmolar by adding sucrose (1560 mmol/l).
RESULTS:The L-M ratio was 2–3 times higher at diagnosis than either at 8 months to 2 years gluten free, or beyond 2 years gluten free, consecutively. The L-M ratio (mean, range) was significantly higher in cases of biopsies with (sub)total villous atrophy (VA) (0.388, 0.062–0.804, n = 28), partial VA (0.240, 0.062–0.841, n=18) and villous irregularity (0.143, 0.017–0.322, n = 29) than in case of normalized histology after GFD (0.085, 0.021–0.230, n = 19). The rate of normalization of functional integrity was slower in adults than in children, demonstrated by a combination of histology and SAT.
CONCLUSION:The SAT correlates well with the degree of VA. It is important for daily clinical practice that the simple and non-invasive SAT can be used as an indicator of intestinal damage, thus influencing need for and timing of intestinal biopsies.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8724020</pmid><doi>10.1097/00042737-199603000-00006</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 1996-03, Vol.8 (3), p.219-224 |
| issn | 0954-691X 1473-5687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78204075 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Aged Atrophy Biological and medical sciences Biopsy Celiac Disease - diet therapy Celiac Disease - metabolism Celiac Disease - pathology Child Child, Preschool Chromatography, Gas Fasting Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Agents - pharmacokinetics Gastrointestinal Agents - urine Glutens Humans Infant Intestinal Absorption Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine, Small - metabolism Intestine, Small - pathology Lactulose - pharmacokinetics Lactulose - urine Male Mannitol - pharmacokinetics Mannitol - urine Medical sciences Middle Aged Osmolar Concentration Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Sucrose - pharmacokinetics |
| title | Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A33%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Follow-up%20of%20treated%20coeliac%20patients:%20sugar%20absorption%20test%20and%20intestinal%20biopsies%20compared&rft.jtitle=European%20journal%20of%20gastroenterology%20&%20hepatology&rft.au=Uil,%20Jan%20J&rft.date=1996-03&rft.volume=8&rft.issue=3&rft.spage=219&rft.epage=224&rft.pages=219-224&rft.issn=0954-691X&rft.eissn=1473-5687&rft_id=info:doi/10.1097/00042737-199603000-00006&rft_dat=%3Cproquest_cross%3E78204075%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78204075&rft_id=info:pmid/8724020&rfr_iscdi=true |