Effect of brofaromine and pargyline on human plasma melatonin concentrations

Bieck, Peter R., Karl-Heinz Antonin, Richard Balon and Gregory Oxenkrug: Effect of brofaromine and pargyline on human plasma melatonin concentrations. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1988, 12 : 93–101. 1. 1. Plasma melatonin was used to determine the influence of two monoamine oxi...

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Veröffentlicht in:Progress in neuro-psychopharmacology & biological psychiatry 1988, Vol.12 (1), p.93-101
Hauptverfasser: Bieck, Peter R., Antonin, Karl-Heinz, Balon, Richard, Oxenkrug, Gregory
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container_issue 1
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container_title Progress in neuro-psychopharmacology & biological psychiatry
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creator Bieck, Peter R.
Antonin, Karl-Heinz
Balon, Richard
Oxenkrug, Gregory
description Bieck, Peter R., Karl-Heinz Antonin, Richard Balon and Gregory Oxenkrug: Effect of brofaromine and pargyline on human plasma melatonin concentrations. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1988, 12 : 93–101. 1. 1. Plasma melatonin was used to determine the influence of two monoamine oxidase inhibitor drugs in 11 normal subjects. 2. 2. Acute oral administration of the selective reversible MAO-A inhibitor brofaromine but not of the — in low doses — selective MAO-B inhibitor pargyline increased daytime melatonin with large variations in onset, degree and duration. 3. 3. Further investigation of this selective action on melatonin might help to better understand the action of the therapeutically effective antidepressive therapy with selective MAO-A inhibitors.
doi_str_mv 10.1016/0278-5846(88)90064-4
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subjects Administration, Oral
Adult
Biological and medical sciences
brofaromine
Circadian Rhythm - drug effects
Dose-Response Relationship, Drug
Humans
MAO-A inhibition
Medical sciences
Melatonin - blood
Monoamine Oxidase Inhibitors - pharmacology
Neuropharmacology
normal subjects
pargyline
Pargyline - pharmacology
Pharmacology. Drug treatments
Piperidines - pharmacology
plasma melatonin
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
title Effect of brofaromine and pargyline on human plasma melatonin concentrations
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