Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A southeastern cancer study group report
Bone marrow and peripheral blood findings at the time of complete remission were analyzed in 333 patients with acute myelogenous leukemia to determine if any variables were predictive for remission duration and survival. Patients were categorized as to percentage of blasts, promyelocytes, erythroid...
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| Veröffentlicht in: | Cancer 1988-06, Vol.61 (12), p.2481-2486 |
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| creator | Vogler, William R. Raney, Marilyn R. |
| description | Bone marrow and peripheral blood findings at the time of complete remission were analyzed in 333 patients with acute myelogenous leukemia to determine if any variables were predictive for remission duration and survival. Patients were categorized as to percentage of blasts, promyelocytes, erythroid precursors and lymphocytes in the marrow and hemoglobin concentration, leukocyte and platelet counts, and percentage of granulocytes and blasts in the blood. Additionally, the degree of cellularity in the marrow aspirate and biopsy were analyzed. Patients with |
| doi_str_mv | 10.1002/1097-0142(19880615)61:12<2481::AID-CNCR2820611216>3.0.CO;2-D |
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The presence of <1% blasts in the marrow, normal or decreased biopsy cellularity, and no anemia at the time of remission defined a “good” prognostic group. The quality of remission should be assessed in evaluating the results of therapy and assigning further treatment.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19880615)61:12<2481::AID-CNCR2820611216>3.0.CO;2-D</identifier><identifier>PMID: 3163256</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Blood Cell Count ; Bone Marrow - pathology ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Myeloid, Acute - blood ; Leukemia, Myeloid, Acute - drug therapy ; Leukemia, Myeloid, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Prognosis ; Remission Induction ; Statistics as Topic</subject><ispartof>Cancer, 1988-06, Vol.61 (12), p.2481-2486</ispartof><rights>Copyright © 1988 American Cancer Society</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4166-73be47a57c38f1442f68da6cc5c39a8e62a92bb6888c6f877ec3b038a3de44403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7684451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3163256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogler, William R.</creatorcontrib><creatorcontrib>Raney, Marilyn R.</creatorcontrib><title>Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A southeastern cancer study group report</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Bone marrow and peripheral blood findings at the time of complete remission were analyzed in 333 patients with acute myelogenous leukemia to determine if any variables were predictive for remission duration and survival. Patients were categorized as to percentage of blasts, promyelocytes, erythroid precursors and lymphocytes in the marrow and hemoglobin concentration, leukocyte and platelet counts, and percentage of granulocytes and blasts in the blood. Additionally, the degree of cellularity in the marrow aspirate and biopsy were analyzed. Patients with <4% blasts in the marrow had significantly longer remission durations than those with blasts ≥1% (P < 0.01). Those with hypercellular marrows had significantly shorter remission (P < 0.05) and survival (P < 0.01). The transient presence of more than 3% blasts in the blood also was suggestive of a shorter remission duration and survival.
The presence of <1% blasts in the marrow, normal or decreased biopsy cellularity, and no anemia at the time of remission defined a “good” prognostic group. The quality of remission should be assessed in evaluating the results of therapy and assigning further treatment.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Bone Marrow - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - blood</subject><subject>Leukemia, Myeloid, Acute - drug therapy</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Remission Induction</subject><subject>Statistics as Topic</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd2K1DAAhYMo6-zqIwi5EHEvOuavSWZWhKHjz8LiiCh4IYQ0TWu0k4xJyzKP4FubOuOAXgheNeV8OZycA8AaozlGiDzDaCEKhBl5ihdSIo7LS46XmDwnTOLlcnW9Lqq31XsiSdYwwfwFnaN5tbkixfoOmJ2u3wUzhJAsSkY_3QfnKX3Nv4KU9AycUcwpKfkM_HgXQ-dDGpyByXXetc5obywMLaz7EBqofQO3OsZwC1vnG-e7BJ2H2oyDhdu97UNnfRgT7O34zW6dntSYDym54OdwBVMYhy9Wp8FGD3-5R5iGsdnDLoZxl-FdiMMDcK_VfbIPj98L8PHVyw_Vm-Jm8_q6Wt0UhmHOC0Fry4QuhaGyxYyRlstGc2NKQxdaWk70gtQ1l1Ia3kohrKE1olLTxjLGEL0ATw6-uxi-jzYNKkc1tu-1t_kZSuResUAig58PoIkhpWhbtYsuN7FXGKlpKTVVraaq1e-lFMcKEzUtpVReSv25lKIKqWqjiFpn-0fHHGO9tc3J_DhN1h8fdZ2M7tuYi3PphAkuGStxxroDdut6u__PiP9M-JdCfwJWgMB-</recordid><startdate>19880615</startdate><enddate>19880615</enddate><creator>Vogler, William R.</creator><creator>Raney, Marilyn R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880615</creationdate><title>Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A southeastern cancer study group report</title><author>Vogler, William R. ; Raney, Marilyn R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4166-73be47a57c38f1442f68da6cc5c39a8e62a92bb6888c6f877ec3b038a3de44403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>Bone Marrow - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - blood</topic><topic>Leukemia, Myeloid, Acute - drug therapy</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Remission Induction</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogler, William R.</creatorcontrib><creatorcontrib>Raney, Marilyn R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogler, William R.</au><au>Raney, Marilyn R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A southeastern cancer study group report</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1988-06-15</date><risdate>1988</risdate><volume>61</volume><issue>12</issue><spage>2481</spage><epage>2486</epage><pages>2481-2486</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Bone marrow and peripheral blood findings at the time of complete remission were analyzed in 333 patients with acute myelogenous leukemia to determine if any variables were predictive for remission duration and survival. Patients were categorized as to percentage of blasts, promyelocytes, erythroid precursors and lymphocytes in the marrow and hemoglobin concentration, leukocyte and platelet counts, and percentage of granulocytes and blasts in the blood. Additionally, the degree of cellularity in the marrow aspirate and biopsy were analyzed. Patients with <4% blasts in the marrow had significantly longer remission durations than those with blasts ≥1% (P < 0.01). Those with hypercellular marrows had significantly shorter remission (P < 0.05) and survival (P < 0.01). The transient presence of more than 3% blasts in the blood also was suggestive of a shorter remission duration and survival.
The presence of <1% blasts in the marrow, normal or decreased biopsy cellularity, and no anemia at the time of remission defined a “good” prognostic group. The quality of remission should be assessed in evaluating the results of therapy and assigning further treatment.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3163256</pmid><doi>10.1002/1097-0142(19880615)61:12<2481::AID-CNCR2820611216>3.0.CO;2-D</doi><tpages>6</tpages></addata></record> |
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| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood Cell Count Bone Marrow - pathology Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Prognosis Remission Induction Statistics as Topic |
| title | Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A southeastern cancer study group report |
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