Testicular function and leydig cell ultrastructure in long-term bilaterally cryptorchid rams
This study was conducted to investigate the effects of bilateral cryptorchidism induced in adult rams on testicular function and Leydig cell ultrastructure. The results indicated that long-term bilateral cryptorchidism resulted in decreased testicular size, degeneration of seminiferous tubules, elev...
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| Veröffentlicht in: | Biology of reproduction 1988-02, Vol.38 (1), p.211-220 |
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| container_title | Biology of reproduction |
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| creator | Lunstra, D.D Schanbacher, B.D |
| description | This study was conducted to investigate the effects of bilateral cryptorchidism induced in adult rams on testicular function
and Leydig cell ultrastructure. The results indicated that long-term bilateral cryptorchidism resulted in decreased testicular
size, degeneration of seminiferous tubules, elevated serum LH levels, maintenance of normal testosterone concentrations in
peripheral and spermatic vein serum, impairment of the magnitude and duration of androgen response to exogenous luteinizing
hormone (LH), a 13-fold reduction in total number of Leydig cells/paired testes, and a 3-fold hypertrophy in the average size
of remaining Leydig cells. Based on quantitative morphometry, the hypertrophied Leydig cells exhibited significant increases
in the volume of intracellular organelles, including the cell nucleus, mitochondria, smooth and rough endoplasmic reticulum,
lysosome-like bodies and lipid vesicles. Quantitatively, the hypertrophy alone was not enough to offset the loss in number
of Leydig cells and was insufficient to explain the maintenance of normal levels of testosterone in jugular and spermatic
venous blood. The additional mechanisms responsible for production of normal serum testosterone levels in the cryptorchid
ram remain to be elucidated. |
| doi_str_mv | 10.1095/biolreprod38.1.211 |
| format | Article |
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and Leydig cell ultrastructure. The results indicated that long-term bilateral cryptorchidism resulted in decreased testicular
size, degeneration of seminiferous tubules, elevated serum LH levels, maintenance of normal testosterone concentrations in
peripheral and spermatic vein serum, impairment of the magnitude and duration of androgen response to exogenous luteinizing
hormone (LH), a 13-fold reduction in total number of Leydig cells/paired testes, and a 3-fold hypertrophy in the average size
of remaining Leydig cells. Based on quantitative morphometry, the hypertrophied Leydig cells exhibited significant increases
in the volume of intracellular organelles, including the cell nucleus, mitochondria, smooth and rough endoplasmic reticulum,
lysosome-like bodies and lipid vesicles. Quantitatively, the hypertrophy alone was not enough to offset the loss in number
of Leydig cells and was insufficient to explain the maintenance of normal levels of testosterone in jugular and spermatic
venous blood. The additional mechanisms responsible for production of normal serum testosterone levels in the cryptorchid
ram remain to be elucidated.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod38.1.211</identifier><identifier>PMID: 2896521</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; BELIER ; Biological and medical sciences ; CRIPTORQUIDISMO ; CRYPTORCHIDIE ; CRYPTORCHIDISM ; Cryptorchidism - pathology ; Cryptorchidism - physiopathology ; Gynecology. Andrology. Obstetrics ; Leydig Cells - ultrastructure ; Male ; Male genital diseases ; Medical sciences ; MORUECO ; Non tumoral diseases ; RAMS ; Sheep ; TESTES ; TESTICULE ; TESTICULOS ; Testis - pathology ; Testis - physiopathology ; ULTRAESTRUCTURA ; ULTRASTRUCTURE</subject><ispartof>Biology of reproduction, 1988-02, Vol.38 (1), p.211-220</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7133166$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2896521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lunstra, D.D</creatorcontrib><creatorcontrib>Schanbacher, B.D</creatorcontrib><title>Testicular function and leydig cell ultrastructure in long-term bilaterally cryptorchid rams</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>This study was conducted to investigate the effects of bilateral cryptorchidism induced in adult rams on testicular function
and Leydig cell ultrastructure. The results indicated that long-term bilateral cryptorchidism resulted in decreased testicular
size, degeneration of seminiferous tubules, elevated serum LH levels, maintenance of normal testosterone concentrations in
peripheral and spermatic vein serum, impairment of the magnitude and duration of androgen response to exogenous luteinizing
hormone (LH), a 13-fold reduction in total number of Leydig cells/paired testes, and a 3-fold hypertrophy in the average size
of remaining Leydig cells. Based on quantitative morphometry, the hypertrophied Leydig cells exhibited significant increases
in the volume of intracellular organelles, including the cell nucleus, mitochondria, smooth and rough endoplasmic reticulum,
lysosome-like bodies and lipid vesicles. Quantitatively, the hypertrophy alone was not enough to offset the loss in number
of Leydig cells and was insufficient to explain the maintenance of normal levels of testosterone in jugular and spermatic
venous blood. The additional mechanisms responsible for production of normal serum testosterone levels in the cryptorchid
ram remain to be elucidated.</description><subject>Animals</subject><subject>BELIER</subject><subject>Biological and medical sciences</subject><subject>CRIPTORQUIDISMO</subject><subject>CRYPTORCHIDIE</subject><subject>CRYPTORCHIDISM</subject><subject>Cryptorchidism - pathology</subject><subject>Cryptorchidism - physiopathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Leydig Cells - ultrastructure</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>MORUECO</subject><subject>Non tumoral diseases</subject><subject>RAMS</subject><subject>Sheep</subject><subject>TESTES</subject><subject>TESTICULE</subject><subject>TESTICULOS</subject><subject>Testis - pathology</subject><subject>Testis - physiopathology</subject><subject>ULTRAESTRUCTURA</subject><subject>ULTRASTRUCTURE</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc2LFDEQxYO4rOPqPyAKOai3HvPRnVQfZdlVYWEP7t6EUJ2PmUi6e0y6Gea_NzKDpyp4Px5V7xHyjrMtZ333ZYhzyv6QZydhy7eC8xdkwzvRN1ooeEk2jDHVSKnkK_K6lN-M8VYKeU2uBfSqE3xDfj35skS7Jsw0rJNd4jxRnBxN_uTijlqfEl3TkrEsebXLmj2NE03ztGsWn0c6xIR1wZRO1ObTYZmz3UdHM47lDbkKmIp_e5k35Pn-7un2e_Pw-O3H7deHJghQS-PRKtZx1wofrLaudQMCE1oCBAsYeFA4sM5qpULbamk1ODV4L2GwHWgmb8jns2-N4s9aHzJjLP8ux8nPazEaeN93HVTwwwVch9E7c8hxxHwylziq_vGiY7GYQsbJxvIf01xKrlTFPp2xfdztjzF7U8YaQDWV5ng8SjDc1DIq9_7MBZwN7nK1ev4JIJTuOID8CyIjiM0</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>Lunstra, D.D</creator><creator>Schanbacher, B.D</creator><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19880201</creationdate><title>Testicular function and leydig cell ultrastructure in long-term bilaterally cryptorchid rams</title><author>Lunstra, D.D ; Schanbacher, B.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f286t-eac6051d42efc7cd4dba8027388fc8af1f6ab05c766f4473c78d6bee38bc58703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>BELIER</topic><topic>Biological and medical sciences</topic><topic>CRIPTORQUIDISMO</topic><topic>CRYPTORCHIDIE</topic><topic>CRYPTORCHIDISM</topic><topic>Cryptorchidism - pathology</topic><topic>Cryptorchidism - physiopathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Leydig Cells - ultrastructure</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>MORUECO</topic><topic>Non tumoral diseases</topic><topic>RAMS</topic><topic>Sheep</topic><topic>TESTES</topic><topic>TESTICULE</topic><topic>TESTICULOS</topic><topic>Testis - pathology</topic><topic>Testis - physiopathology</topic><topic>ULTRAESTRUCTURA</topic><topic>ULTRASTRUCTURE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lunstra, D.D</creatorcontrib><creatorcontrib>Schanbacher, B.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lunstra, D.D</au><au>Schanbacher, B.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular function and leydig cell ultrastructure in long-term bilaterally cryptorchid rams</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>38</volume><issue>1</issue><spage>211</spage><epage>220</epage><pages>211-220</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>This study was conducted to investigate the effects of bilateral cryptorchidism induced in adult rams on testicular function
and Leydig cell ultrastructure. The results indicated that long-term bilateral cryptorchidism resulted in decreased testicular
size, degeneration of seminiferous tubules, elevated serum LH levels, maintenance of normal testosterone concentrations in
peripheral and spermatic vein serum, impairment of the magnitude and duration of androgen response to exogenous luteinizing
hormone (LH), a 13-fold reduction in total number of Leydig cells/paired testes, and a 3-fold hypertrophy in the average size
of remaining Leydig cells. Based on quantitative morphometry, the hypertrophied Leydig cells exhibited significant increases
in the volume of intracellular organelles, including the cell nucleus, mitochondria, smooth and rough endoplasmic reticulum,
lysosome-like bodies and lipid vesicles. Quantitatively, the hypertrophy alone was not enough to offset the loss in number
of Leydig cells and was insufficient to explain the maintenance of normal levels of testosterone in jugular and spermatic
venous blood. The additional mechanisms responsible for production of normal serum testosterone levels in the cryptorchid
ram remain to be elucidated.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>2896521</pmid><doi>10.1095/biolreprod38.1.211</doi><tpages>10</tpages></addata></record> |
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| ispartof | Biology of reproduction, 1988-02, Vol.38 (1), p.211-220 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78199558 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals BELIER Biological and medical sciences CRIPTORQUIDISMO CRYPTORCHIDIE CRYPTORCHIDISM Cryptorchidism - pathology Cryptorchidism - physiopathology Gynecology. Andrology. Obstetrics Leydig Cells - ultrastructure Male Male genital diseases Medical sciences MORUECO Non tumoral diseases RAMS Sheep TESTES TESTICULE TESTICULOS Testis - pathology Testis - physiopathology ULTRAESTRUCTURA ULTRASTRUCTURE |
| title | Testicular function and leydig cell ultrastructure in long-term bilaterally cryptorchid rams |
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