Tissue inhibitor of metalloproteinase‐1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

Liver fibrosis results from a relative imbalance between synthesis and degradation of matrix proteins. We have previously described release of the protein collagenase inhibitor, tissue inhibitor of metalloproteinase‐1 (TIMP‐1), by culture‐activated human hepatic stellate cells (HSCs). In this study,...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1996-07, Vol.24 (1), p.176-184
Hauptverfasser:	Iredale, J P, Benyon, R C, Arthur, M J, Ferris, W F, Alcolado, R, Winwood, P J, Clark, N, Murphy, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Bile Ducts - physiology Biological and medical sciences Blotting, Northern Blotting, Western Cattle Cells, Cultured Cloning, Molecular Collagenases - biosynthesis Gastroenterology. Liver. Pancreas. Abdomen Glycoproteins - biosynthesis Humans Liver - injuries Liver - metabolism Liver Cirrhosis, Experimental - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix Metalloproteinase 1 Medical sciences Mice Molecular Sequence Data Other diseases. Semiology Polymerase Chain Reaction Rabbits Rats RNA, Messenger - biosynthesis Sequence Homology, Amino Acid Tissue Inhibitor of Metalloproteinases Transcription, Genetic
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