Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum
The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The tot...
Gespeichert in:
| Veröffentlicht in: | Experimental neurology 1988-05, Vol.100 (2), p.354-364 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 364 |
|---|---|
| container_issue | 2 |
| container_start_page | 354 |
| container_title | Experimental neurology |
| container_volume | 100 |
| creator | Hannah, R.S. Roth, S.H. Spira, A.W. |
| description | The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The total segment length, mean terminal path length, and mean vertex path length were reduced in the treated cells. The pattern of segment frequency as related to equivalent orders was abnormal in the treated cells. The
Va
Vb
vertex ratios and the levels of trichotomy indicated that the treated cells underwent nonrandom remodeling, unlike the control cells which exhibited dichotomous, random terminal branching. These observations confirm that phenobarbital produces distinct long-term morphologic alterations in Purkinje cells. |
| doi_str_mv | 10.1016/0014-4886(88)90114-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78197342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014488688901148</els_id><sourcerecordid>78197342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-d456b4feac39d2e43684c1381ae400cb469a753d27642e83540215f24b6102e43</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJSLZp_0EDOoTSHpyMLFmWLoGypG0gpDm0ZyHL464Sf2wkOaX_vnJ32WNOw_A-7zA8hHxgcMmAySsAJgqhlPyk1GcNLG_qDVkx0FCUgsMRWR2QU_I2xkcA0KKsT8gJ5xKgFityf9N16BKdOrrd4Dg1NjQ-2Z5OI32Yw5MfH5E67Hv6O0x_0oZubUoYxkj9SNMGabAp5wGbzMzDO3Lc2T7i-_08I7--3vxcfy_ufny7XX-5KxxXMhWtqGQjOrSO67ZEwaUSjnHFLAoA1wipbV3xtqylKFHxSkDJqq4UjWSw8Gfk4-7uNkzPM8ZkBh-XN-2I0xxNrZiuuSgzKHagC1OMATuzDX6w4a9hYBaNZnFkFkdGKfNfo1G5dr6_PzcDtofS3lvOL_a5jc72XbCj8_GA1aA14zJj1zsMs4sXj8FE53F02PqQrZt28q__8Q-pDYzK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78197342</pqid></control><display><type>article</type><title>Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hannah, R.S. ; Roth, S.H. ; Spira, A.W.</creator><creatorcontrib>Hannah, R.S. ; Roth, S.H. ; Spira, A.W.</creatorcontrib><description>The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The total segment length, mean terminal path length, and mean vertex path length were reduced in the treated cells. The pattern of segment frequency as related to equivalent orders was abnormal in the treated cells. The
Va
Vb
vertex ratios and the levels of trichotomy indicated that the treated cells underwent nonrandom remodeling, unlike the control cells which exhibited dichotomous, random terminal branching. These observations confirm that phenobarbital produces distinct long-term morphologic alterations in Purkinje cells.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(88)90114-8</identifier><identifier>PMID: 3360074</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Growth - drug effects ; Hypnotics. Sedatives ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Phenobarbital - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Purkinje Cells - drug effects ; Purkinje Cells - physiology ; Rats</subject><ispartof>Experimental neurology, 1988-05, Vol.100 (2), p.354-364</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d456b4feac39d2e43684c1381ae400cb469a753d27642e83540215f24b6102e43</citedby><cites>FETCH-LOGICAL-c386t-d456b4feac39d2e43684c1381ae400cb469a753d27642e83540215f24b6102e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014488688901148$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7099136$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3360074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hannah, R.S.</creatorcontrib><creatorcontrib>Roth, S.H.</creatorcontrib><creatorcontrib>Spira, A.W.</creatorcontrib><title>Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The total segment length, mean terminal path length, and mean vertex path length were reduced in the treated cells. The pattern of segment frequency as related to equivalent orders was abnormal in the treated cells. The
Va
Vb
vertex ratios and the levels of trichotomy indicated that the treated cells underwent nonrandom remodeling, unlike the control cells which exhibited dichotomous, random terminal branching. These observations confirm that phenobarbital produces distinct long-term morphologic alterations in Purkinje cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Growth - drug effects</subject><subject>Hypnotics. Sedatives</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenobarbital - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Purkinje Cells - drug effects</subject><subject>Purkinje Cells - physiology</subject><subject>Rats</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJSLZp_0EDOoTSHpyMLFmWLoGypG0gpDm0ZyHL464Sf2wkOaX_vnJ32WNOw_A-7zA8hHxgcMmAySsAJgqhlPyk1GcNLG_qDVkx0FCUgsMRWR2QU_I2xkcA0KKsT8gJ5xKgFityf9N16BKdOrrd4Dg1NjQ-2Z5OI32Yw5MfH5E67Hv6O0x_0oZubUoYxkj9SNMGabAp5wGbzMzDO3Lc2T7i-_08I7--3vxcfy_ufny7XX-5KxxXMhWtqGQjOrSO67ZEwaUSjnHFLAoA1wipbV3xtqylKFHxSkDJqq4UjWSw8Gfk4-7uNkzPM8ZkBh-XN-2I0xxNrZiuuSgzKHagC1OMATuzDX6w4a9hYBaNZnFkFkdGKfNfo1G5dr6_PzcDtofS3lvOL_a5jc72XbCj8_GA1aA14zJj1zsMs4sXj8FE53F02PqQrZt28q__8Q-pDYzK</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Hannah, R.S.</creator><creator>Roth, S.H.</creator><creator>Spira, A.W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum</title><author>Hannah, R.S. ; Roth, S.H. ; Spira, A.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d456b4feac39d2e43684c1381ae400cb469a753d27642e83540215f24b6102e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Growth - drug effects</topic><topic>Hypnotics. Sedatives</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenobarbital - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Purkinje Cells - drug effects</topic><topic>Purkinje Cells - physiology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hannah, R.S.</creatorcontrib><creatorcontrib>Roth, S.H.</creatorcontrib><creatorcontrib>Spira, A.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hannah, R.S.</au><au>Roth, S.H.</au><au>Spira, A.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>100</volume><issue>2</issue><spage>354</spage><epage>364</epage><pages>354-364</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The total segment length, mean terminal path length, and mean vertex path length were reduced in the treated cells. The pattern of segment frequency as related to equivalent orders was abnormal in the treated cells. The
Va
Vb
vertex ratios and the levels of trichotomy indicated that the treated cells underwent nonrandom remodeling, unlike the control cells which exhibited dichotomous, random terminal branching. These observations confirm that phenobarbital produces distinct long-term morphologic alterations in Purkinje cells.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3360074</pmid><doi>10.1016/0014-4886(88)90114-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 1988-05, Vol.100 (2), p.354-364 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78197342 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Growth - drug effects Hypnotics. Sedatives Medical sciences Neuropharmacology Pharmacology. Drug treatments Phenobarbital - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopharmacology Purkinje Cells - drug effects Purkinje Cells - physiology Rats |
| title | Effect of phenobarbital on Purkinje cell growth patterns in the rat cerebellum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T07%3A41%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20phenobarbital%20on%20Purkinje%20cell%20growth%20patterns%20in%20the%20rat%20cerebellum&rft.jtitle=Experimental%20neurology&rft.au=Hannah,%20R.S.&rft.date=1988-05-01&rft.volume=100&rft.issue=2&rft.spage=354&rft.epage=364&rft.pages=354-364&rft.issn=0014-4886&rft.eissn=1090-2430&rft.coden=EXNEAC&rft_id=info:doi/10.1016/0014-4886(88)90114-8&rft_dat=%3Cproquest_cross%3E78197342%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78197342&rft_id=info:pmid/3360074&rft_els_id=0014488688901148&rfr_iscdi=true |