Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface of T-helper lymphocytes. Sustained treatment with the monoclonal antibody led to cessation of the lymphocytic infiltration associated with t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1988-04, Vol.240 (4852), p.659-662
Hauptverfasser:	Shizuru, Judith A., Taylor-Edwards, Cariel, Banks, Beth Ann, Gregory, Anita K., Fathman, C. Garrison
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - therapeutic use Antigens Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences Cyclosporins - therapeutic use Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - therapy Diabetes. Impaired glucose tolerance Drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female House mouse Hyperglycemia Immunity (Disease) Immunotherapy Islets of Langerhans - pathology Lymphocytes Lymphocytes - pathology Medical research Medical sciences Messenger RNA Mice Mice as laboratory animals Mice, Inbred ICR Monoclonal antibodies Oocytes T cells T lymphocytes T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology Type 1 diabetes mellitus
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