Tomographic myocardial imaging with technetium-99m tetrofosmin : Comparison with tetrofosmin and Thallium planar imaging and with angiography
Technetium-99m tetrofosmin is a new myocardial imaging agent with improved handling and kinetic characteristics. The purpose of this study was to compare the ability of planar and SPECT Tc-99m tetrofosmin imaging with Thallium-201 planar data to detect coronary artery disease and individual vessel l...
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Veröffentlicht in: | European heart journal 1996-04, Vol.17 (4), p.635-642 |
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description | Technetium-99m tetrofosmin is a new myocardial imaging agent with improved handling and kinetic characteristics. The purpose of this study was to compare the ability of planar and SPECT Tc-99m tetrofosmin imaging with Thallium-201 planar data to detect coronary artery disease and individual vessel lesions ( > 50% diameter stenosis). Seventy-two patients with definite or suspected coronary artery disease were included. Sixty-three had angiographic evidence of coronary artery disease, among whom 42 had had a previous myocardial infarction, while 21 had not. The total number of diseased arteries was 111. Patients underwent symptom-limited treadmill or bicycle exercise to similar endpoints. Thallium and tetrofosmin images were analysed separately by consensus reading. Interpretation was made for five standard anatomical regions (anterior, septal, inferior, lateral and apex), classified into four categories (normal, reversible, fixed and mixed defects). Sensitivity and specificity to detect coronary artery disease were 71% and 78% for Thallium-201 vs 68% and 78% for tetrofosmin by planar imaging, and 87% and 89% for tetrofosmin by SPECT. The improved sensitivity of SPECT was confirmed both in patients with and without previous myocardial infarction. The sensitivity to detect individual vessel lesions was improved by SPECT (59% tetrofosmin SPECT vs 50% thallium planar and 51% tetrofosmin planar). Individual vessel lesion detection by SPECT was 50% for the left anterior descending coronary artery, 42% for the left circumflex and 86% for the right coronary artery. This study confirms the value of technetium-99m tetrofosmin as a myocardial imaging agent. Improvements in diagnosis and in evaluating extent of disease can be expected from using SPECT. |
doi_str_mv | 10.1093/oxfordjournals.eurheartj.a014919 |
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The purpose of this study was to compare the ability of planar and SPECT Tc-99m tetrofosmin imaging with Thallium-201 planar data to detect coronary artery disease and individual vessel lesions ( > 50% diameter stenosis). Seventy-two patients with definite or suspected coronary artery disease were included. Sixty-three had angiographic evidence of coronary artery disease, among whom 42 had had a previous myocardial infarction, while 21 had not. The total number of diseased arteries was 111. Patients underwent symptom-limited treadmill or bicycle exercise to similar endpoints. Thallium and tetrofosmin images were analysed separately by consensus reading. Interpretation was made for five standard anatomical regions (anterior, septal, inferior, lateral and apex), classified into four categories (normal, reversible, fixed and mixed defects). Sensitivity and specificity to detect coronary artery disease were 71% and 78% for Thallium-201 vs 68% and 78% for tetrofosmin by planar imaging, and 87% and 89% for tetrofosmin by SPECT. The improved sensitivity of SPECT was confirmed both in patients with and without previous myocardial infarction. The sensitivity to detect individual vessel lesions was improved by SPECT (59% tetrofosmin SPECT vs 50% thallium planar and 51% tetrofosmin planar). Individual vessel lesion detection by SPECT was 50% for the left anterior descending coronary artery, 42% for the left circumflex and 86% for the right coronary artery. This study confirms the value of technetium-99m tetrofosmin as a myocardial imaging agent. Improvements in diagnosis and in evaluating extent of disease can be expected from using SPECT.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a014919</identifier><identifier>PMID: 8733099</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiology. 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The purpose of this study was to compare the ability of planar and SPECT Tc-99m tetrofosmin imaging with Thallium-201 planar data to detect coronary artery disease and individual vessel lesions ( > 50% diameter stenosis). Seventy-two patients with definite or suspected coronary artery disease were included. Sixty-three had angiographic evidence of coronary artery disease, among whom 42 had had a previous myocardial infarction, while 21 had not. The total number of diseased arteries was 111. Patients underwent symptom-limited treadmill or bicycle exercise to similar endpoints. Thallium and tetrofosmin images were analysed separately by consensus reading. Interpretation was made for five standard anatomical regions (anterior, septal, inferior, lateral and apex), classified into four categories (normal, reversible, fixed and mixed defects). Sensitivity and specificity to detect coronary artery disease were 71% and 78% for Thallium-201 vs 68% and 78% for tetrofosmin by planar imaging, and 87% and 89% for tetrofosmin by SPECT. The improved sensitivity of SPECT was confirmed both in patients with and without previous myocardial infarction. The sensitivity to detect individual vessel lesions was improved by SPECT (59% tetrofosmin SPECT vs 50% thallium planar and 51% tetrofosmin planar). Individual vessel lesion detection by SPECT was 50% for the left anterior descending coronary artery, 42% for the left circumflex and 86% for the right coronary artery. This study confirms the value of technetium-99m tetrofosmin as a myocardial imaging agent. Improvements in diagnosis and in evaluating extent of disease can be expected from using SPECT.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Echo-Planar Imaging</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart</subject><subject>Heart - diagnostic imaging</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organophosphorus Compounds</subject><subject>Organotechnetium Compounds</subject><subject>Sensitivity and Specificity</subject><subject>Thallium Radioisotopes</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc2O0zAUhS0EGsrAIyBlgRCblOs4tmNWoIo_aSQ2XbCLbh2ncRXbwU409CF4Zzw0FLGyrHPu8bn-CHlDYUtBsbfhZx9idwpL9DimrVniYDDOpy0CrRVVj8iG8qoqlaj5Y7IBqngpRPP9KXmW0gkAGkHFDblpJGOg1Ib82gcXjhGnwerCnYPG2FkcC-vwaP2xuLfzUMxGD97MdnGlUi5f5xj6kJz1xbtiF9yE0abg_5r_qei7Yj_gOObRYhrRY7wmP2h_BtAf7aXC-Tl50ue9zIv1vCX7Tx_3uy_l3bfPX3cf7kpdUzaXijNdsYMSHLioeINgqGTigD30IKQCgVpqybGqO0mZ1geETmmh-0YgUnZLXl9ipxh-LCbNrbNJmzEXNGFJrWzyv0GtsvH9xahjSCmavp1i7h_PLYX2AUj7P5D2CqRdgeSIl-tby8GZ7hqwEsj6q1XHpHHsI3pt09XGQFaSC_YbAGChlQ</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>BENOIT, T</creator><creator>VIVEGNIS, D</creator><creator>LAHIRI, A</creator><creator>ITTI, R</creator><creator>BRAAT, S</creator><creator>RIGO, P</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Tomographic myocardial imaging with technetium-99m tetrofosmin : Comparison with tetrofosmin and Thallium planar imaging and with angiography</title><author>BENOIT, T ; VIVEGNIS, D ; LAHIRI, A ; ITTI, R ; BRAAT, S ; RIGO, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-953c23b965056258a0e1736baf0f067906ac7c75a24d713ccba0d9c6cf86aa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Echo-Planar Imaging</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart</topic><topic>Heart - diagnostic imaging</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organophosphorus Compounds</topic><topic>Organotechnetium Compounds</topic><topic>Sensitivity and Specificity</topic><topic>Thallium Radioisotopes</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BENOIT, T</creatorcontrib><creatorcontrib>VIVEGNIS, D</creatorcontrib><creatorcontrib>LAHIRI, A</creatorcontrib><creatorcontrib>ITTI, R</creatorcontrib><creatorcontrib>BRAAT, S</creatorcontrib><creatorcontrib>RIGO, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BENOIT, T</au><au>VIVEGNIS, D</au><au>LAHIRI, A</au><au>ITTI, R</au><au>BRAAT, S</au><au>RIGO, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tomographic myocardial imaging with technetium-99m tetrofosmin : Comparison with tetrofosmin and Thallium planar imaging and with angiography</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>17</volume><issue>4</issue><spage>635</spage><epage>642</epage><pages>635-642</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Technetium-99m tetrofosmin is a new myocardial imaging agent with improved handling and kinetic characteristics. The purpose of this study was to compare the ability of planar and SPECT Tc-99m tetrofosmin imaging with Thallium-201 planar data to detect coronary artery disease and individual vessel lesions ( > 50% diameter stenosis). Seventy-two patients with definite or suspected coronary artery disease were included. Sixty-three had angiographic evidence of coronary artery disease, among whom 42 had had a previous myocardial infarction, while 21 had not. The total number of diseased arteries was 111. Patients underwent symptom-limited treadmill or bicycle exercise to similar endpoints. Thallium and tetrofosmin images were analysed separately by consensus reading. Interpretation was made for five standard anatomical regions (anterior, septal, inferior, lateral and apex), classified into four categories (normal, reversible, fixed and mixed defects). Sensitivity and specificity to detect coronary artery disease were 71% and 78% for Thallium-201 vs 68% and 78% for tetrofosmin by planar imaging, and 87% and 89% for tetrofosmin by SPECT. The improved sensitivity of SPECT was confirmed both in patients with and without previous myocardial infarction. The sensitivity to detect individual vessel lesions was improved by SPECT (59% tetrofosmin SPECT vs 50% thallium planar and 51% tetrofosmin planar). Individual vessel lesion detection by SPECT was 50% for the left anterior descending coronary artery, 42% for the left circumflex and 86% for the right coronary artery. This study confirms the value of technetium-99m tetrofosmin as a myocardial imaging agent. Improvements in diagnosis and in evaluating extent of disease can be expected from using SPECT.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8733099</pmid><doi>10.1093/oxfordjournals.eurheartj.a014919</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Biological and medical sciences Cardiology. Vascular system Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Coronary heart disease Echo-Planar Imaging Exercise Test Female Heart Heart - diagnostic imaging Hemodynamics Humans Image Interpretation, Computer-Assisted Male Medical sciences Middle Aged Organophosphorus Compounds Organotechnetium Compounds Sensitivity and Specificity Thallium Radioisotopes Tomography, Emission-Computed, Single-Photon |
title | Tomographic myocardial imaging with technetium-99m tetrofosmin : Comparison with tetrofosmin and Thallium planar imaging and with angiography |
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