Effects of SKF 108922, an HIV-1 protease inhibitor, on retrovirus replication in mice

Rationally designed synthetic inhibitors of retroviral proteases inhibit the processing of viral polypeptides in cultures of human T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1) and therefore suppress the infectivity of HIV-1 in vitro. We have previously reported the antivir...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antiviral research 1996-03, Vol.29 (2), p.175-186
Hauptverfasser:	Black, Paul L., Ussery, Michael A., Barney, Shawn, Wittrock, Robert, DeMarsh, Peter, Dreyer, Geoffrey B., Petteway, Stephen R., DalMonte, Paul, Baldoni, John, Lambert, Dennis M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin AIDS/HIV Animal model Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - blood Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use beta-Cyclodextrins Biological and medical sciences Cell Line Cyclodextrins - pharmacology Female HIV Protease Inhibitors - blood HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - therapeutic use human immunodeficiency virus 1 Humans Injections, Intraperitoneal Injections, Subcutaneous Leukemia, Experimental - drug therapy Leukemia, Experimental - virology Medical sciences Mice Mice, Inbred BALB C Murine leukemia virus Murine retrovirus Oligopeptides - blood Oligopeptides - pharmacokinetics Oligopeptides - therapeutic use Pharmaceutical Vehicles - pharmacology Pharmacology. Drug treatments Protease inhibitor Rauscher Virus - drug effects Retroviridae Infections - drug therapy Retroviridae Infections - virology RNA-Directed DNA Polymerase - blood Tumor Virus Infections - drug therapy Tumor Virus Infections - virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!