Studies on the synergy between collagen and adjuvant arthritis in rats
Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients recei...
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| Veröffentlicht in: | Cellular immunology 1988-04, Vol.113 (1), p.117-129 |
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| container_title | Cellular immunology |
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| creator | DeJoy, Susan Quinn Ferguson, Kim M. Oronsky, Arnold L. Kerwar, S.S. |
| description | Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia
+ (ED1
+)macrophages, OX-19
+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia
+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia
+ antibody. However, anti-Ia
+ treatment does not induce depletion of serum complement. |
| doi_str_mv | 10.1016/0008-8749(88)90011-1 |
| format | Article |
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+ (ED1
+)macrophages, OX-19
+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia
+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia
+ antibody. However, anti-Ia
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+ (ED1
+)macrophages, OX-19
+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia
+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia
+ antibody. However, anti-Ia
+ treatment does not induce depletion of serum complement.</description><subject>Adjuvants, Immunologic - immunology</subject><subject>Animals</subject><subject>Arthritis - immunology</subject><subject>Arthritis, Experimental - etiology</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Experimental - pathology</subject><subject>Biological and medical sciences</subject><subject>Collagen - immunology</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Immunohistochemistry</subject><subject>Inflammatory joint diseases</subject><subject>Kinetics</subject><subject>Leukocytes, Mononuclear - classification</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - pathology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Synovial Membrane - immunology</subject><subject>Synovial Membrane - pathology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFKJDEQhoOsjKPuGyjksIgeWlPTSXdyEUQcFQQPu3sO6aRaIzNpN0mPzNvb7QxzXE9VRX31U3yEnAC7BAbVFWNMFrLm6lzKC8UYQAF7ZApMsWIGVfmDTHfIATlM6W1kuGITMilnQkHFp2T-O_fOY6JdoPkVaVoHjC9r2mD-QAzUdouFeRkaExw17q1fmZCpifk1-uwT9YFGk9Mx2W_NIuHPbT0if-d3f24fiqfn-8fbm6fCcqhzwRtTKStU6bCdgRJymNuG17JsLSuHjrWqwpoJxRshkStRQwnOCVM7wStVHpGzTe577P71mLJe-mRx-DFg1yddS1C8FPJbEMToZjYm8g1oY5dSxFa_R780ca2B6dGzHkE9StRS6i_PGoaz021-3yzR7Y62Yof9r-3eJGsWbTTB-rTDqkrVwNiAXW8wHKStPEadrMdg0fmINmvX-f__8QmQ5ZgR</recordid><startdate>19880415</startdate><enddate>19880415</enddate><creator>DeJoy, Susan Quinn</creator><creator>Ferguson, Kim M.</creator><creator>Oronsky, Arnold L.</creator><creator>Kerwar, S.S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880415</creationdate><title>Studies on the synergy between collagen and adjuvant arthritis in rats</title><author>DeJoy, Susan Quinn ; Ferguson, Kim M. ; Oronsky, Arnold L. ; Kerwar, S.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4ba69c593def21958ba6fb4783fc03fb40f96e70594b58e4957131dd5a7d54693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adjuvants, Immunologic - immunology</topic><topic>Animals</topic><topic>Arthritis - immunology</topic><topic>Arthritis, Experimental - etiology</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritis, Experimental - pathology</topic><topic>Biological and medical sciences</topic><topic>Collagen - immunology</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Immunohistochemistry</topic><topic>Inflammatory joint diseases</topic><topic>Kinetics</topic><topic>Leukocytes, Mononuclear - classification</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - pathology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Synovial Membrane - immunology</topic><topic>Synovial Membrane - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeJoy, Susan Quinn</creatorcontrib><creatorcontrib>Ferguson, Kim M.</creatorcontrib><creatorcontrib>Oronsky, Arnold L.</creatorcontrib><creatorcontrib>Kerwar, S.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeJoy, Susan Quinn</au><au>Ferguson, Kim M.</au><au>Oronsky, Arnold L.</au><au>Kerwar, S.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the synergy between collagen and adjuvant arthritis in rats</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1988-04-15</date><risdate>1988</risdate><volume>113</volume><issue>1</issue><spage>117</spage><epage>129</epage><pages>117-129</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia
+ (ED1
+)macrophages, OX-19
+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia
+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia
+ antibody. However, anti-Ia
+ treatment does not induce depletion of serum complement.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3259164</pmid><doi>10.1016/0008-8749(88)90011-1</doi><tpages>13</tpages></addata></record> |
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| ispartof | Cellular immunology, 1988-04, Vol.113 (1), p.117-129 |
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| language | eng |
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| subjects | Adjuvants, Immunologic - immunology Animals Arthritis - immunology Arthritis, Experimental - etiology Arthritis, Experimental - immunology Arthritis, Experimental - pathology Biological and medical sciences Collagen - immunology Disease Models, Animal Diseases of the osteoarticular system Immunoglobulin G - administration & dosage Immunohistochemistry Inflammatory joint diseases Kinetics Leukocytes, Mononuclear - classification Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - pathology Male Medical sciences Neutrophils - immunology Neutrophils - pathology Rats Rats, Inbred Lew Synovial Membrane - immunology Synovial Membrane - pathology |
| title | Studies on the synergy between collagen and adjuvant arthritis in rats |
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