Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation

Prostaglandins (PG) have been described as mediators in spinal nociceptive processing after peripheral inflammation. Enzymes essential for PG biosynthesis, cyclooxygenase isozymes COX-1 and COX-2, have not yet been investigated in the spinal cord. In two studies on rats with adjuvant-induced periphe...

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Veröffentlicht in:	FEBS letters 1996-07, Vol.390 (2), p.165-169
Hauptverfasser:	Beiche, Flora, Scheuerer, Stefan, Brune, Kay, Geisslinger, Gerd, Goppelt-Struebe, Margarete
Format:	Artikel
Sprache:	eng
Schlagworte:	4-morpholinepropanesulfonic acid Animals Arthritis, Experimental - enzymology Arthritis, Experimental - genetics Base Sequence basepair central nervous system CFA CNS complete Freund's adjuvant COX cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 DNA Primers - genetics GAPDH glyceraldehyde-3-phosphate dehydrogenase Inflammation Inflammation - enzymology Inflammation - genetics Isoenzymes - genetics kilobase Kinetics Male Membrane Proteins Molecular Sequence Data MOPS non-steroidal anti-inflammatory drugs NSAIDs Polymerase Chain Reaction prostaglandin Prostaglandin-Endoperoxide Synthases - genetics Rats Rats, Sprague-Dawley reverse transcription-polymerase chain reaction RNA, Messenger - genetics RNA, Messenger - metabolism RT-PCR saline sodium citrate Spinal cord Spinal Cord - metabolism SSC Up-Regulation
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