Neutralizing monoclonal antibodies to the AIDS virus

The production of neutralizing monoclonal antibodies (MAbs) will permit the exact localization of neutralizing epitopes on the AIDS virus, HIV-1. We describe the properties of seven MAbs to the envelope of the LAV-1 isolate. Five MAbs recognise the central portion of gp110, amino acids 279-472, and...

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Veröffentlicht in:	AIDS (London) 1988-02, Vol.2 (1), p.25-29
Hauptverfasser:	Thomas, E K, Weber, J N, McClure, J, Clapham, P R, Singhal, M C, Shriver, M K, Weiss, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Antibody Specificity Antigens, Viral - immunology Epitopes - immunology HIV - immunology HIV Antibodies HIV Antigens human immunodeficiency virus Humans Neutralization Tests Retroviridae Proteins - immunology Viral Envelope Proteins - immunology
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Zusammenfassung:	The production of neutralizing monoclonal antibodies (MAbs) will permit the exact localization of neutralizing epitopes on the AIDS virus, HIV-1. We describe the properties of seven MAbs to the envelope of the LAV-1 isolate. Five MAbs recognise the central portion of gp110, amino acids 279-472, and four of these are capable of high-titre neutralization of HIV-1, by infection inhibition, syncytial inhibition and vesicular stomatitis virus (VSV) pseudotype neutralization. One of the two MAbs to gp41 inhibits syncytium formation. Neutralization, live cell immunofluorescence and immunoprecipitation of gp110 are type-specific and restricted to HIV-1 isolates closely related to LAV-1.
ISSN:	0269-9370
DOI:	10.1097/00002030-198802000-00004