Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats
Systematically administered dopamine agonists have been shown to facilitate copulation in male rats. Microinjection of the dopamine agonist apomorphine into the medial preoptic area has also been reported to facilitate sexual behavior. The present experiments investigated the effects of medial preop...
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| Veröffentlicht in: | Brain research 1988-03, Vol.443 (1), p.70-76 |
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| creator | Pehek, Elizabeth A. Warner, Robert K. Bazzett, Terence J. Bitran, Daniel Band, Linda C. Eaton, Robert C. Hull, Elaine M. |
| description | Systematically administered dopamine agonists have been shown to facilitate copulation in male rats. Microinjection of the dopamine agonist apomorphine into the medial preoptic area has also been reported to facilitate sexual behavior. The present experiments investigated the effects of medial preoptic microinjections of the dopamine antagonist
cis-flupenthixol on male rat copulatory behavior. Fewer males initiated copulation and fewer ejaculated following flupenthixol administration. Those males that did ejaculate following flupenthixol injections had fewer ejaculations and longer interintromission intervals. Flupenthixol also antagonized the facilitative effects of apomorphine injections into the medial preoptic area. Flupenthixol and apomorphine produced only minor alterations in non-copulatory behaviors. The results suggest that dopamine receptors within the medial preoptic area are important in the regulation of masculine sexual behavior in the rat. |
| doi_str_mv | 10.1016/0006-8993(88)91599-5 |
| format | Article |
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cis-flupenthixol on male rat copulatory behavior. Fewer males initiated copulation and fewer ejaculated following flupenthixol administration. Those males that did ejaculate following flupenthixol injections had fewer ejaculations and longer interintromission intervals. Flupenthixol also antagonized the facilitative effects of apomorphine injections into the medial preoptic area. Flupenthixol and apomorphine produced only minor alterations in non-copulatory behaviors. The results suggest that dopamine receptors within the medial preoptic area are important in the regulation of masculine sexual behavior in the rat.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(88)91599-5</identifier><identifier>PMID: 3359281</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apomorphine ; Apomorphine - pharmacology ; cis-Flupenthixol ; Copulation - drug effects ; Dopamine ; Estradiol - pharmacology ; Female ; Flupenthixol - administration & dosage ; Flupenthixol - pharmacology ; Male ; Medial preoptic area ; Microinjections ; Ovariectomy ; Preoptic Area - drug effects ; Preoptic Area - physiology ; Rat ; Rats ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Thioxanthenes - pharmacology</subject><ispartof>Brain research, 1988-03, Vol.443 (1), p.70-76</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-bdfd3fe1a8ddd47704c028983005c71fe29821889f988a3597dc2d7ee109c49d3</citedby><cites>FETCH-LOGICAL-c388t-bdfd3fe1a8ddd47704c028983005c71fe29821889f988a3597dc2d7ee109c49d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899388915995$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3359281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pehek, Elizabeth A.</creatorcontrib><creatorcontrib>Warner, Robert K.</creatorcontrib><creatorcontrib>Bazzett, Terence J.</creatorcontrib><creatorcontrib>Bitran, Daniel</creatorcontrib><creatorcontrib>Band, Linda C.</creatorcontrib><creatorcontrib>Eaton, Robert C.</creatorcontrib><creatorcontrib>Hull, Elaine M.</creatorcontrib><title>Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Systematically administered dopamine agonists have been shown to facilitate copulation in male rats. Microinjection of the dopamine agonist apomorphine into the medial preoptic area has also been reported to facilitate sexual behavior. The present experiments investigated the effects of medial preoptic microinjections of the dopamine antagonist
cis-flupenthixol on male rat copulatory behavior. Fewer males initiated copulation and fewer ejaculated following flupenthixol administration. Those males that did ejaculate following flupenthixol injections had fewer ejaculations and longer interintromission intervals. Flupenthixol also antagonized the facilitative effects of apomorphine injections into the medial preoptic area. Flupenthixol and apomorphine produced only minor alterations in non-copulatory behaviors. The results suggest that dopamine receptors within the medial preoptic area are important in the regulation of masculine sexual behavior in the rat.</description><subject>Animals</subject><subject>Apomorphine</subject><subject>Apomorphine - pharmacology</subject><subject>cis-Flupenthixol</subject><subject>Copulation - drug effects</subject><subject>Dopamine</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Flupenthixol - administration & dosage</subject><subject>Flupenthixol - pharmacology</subject><subject>Male</subject><subject>Medial preoptic area</subject><subject>Microinjections</subject><subject>Ovariectomy</subject><subject>Preoptic Area - drug effects</subject><subject>Preoptic Area - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Thioxanthenes - pharmacology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFTEQhYMo43X0HyhkJQrTmnT6UdkMyOALRtzoOuQm1d4aujttkh7Ghf_dtPcyS10VxTlVRX2HsedSvJFCdm-FEF0FWqtXAK-1bLWu2gdsJ6Gvq65uxEO2u7c8Zk9SuimtUlqcsTOlWl2D3LHfX8jFQPMNukxh5mHgjlI1jOuCcz7QXRgvuOU-LHaiGbmds_0RZkr5gtOcA88H5BN6siNfIoYlk-M2ouU0LZZi4gnv1iLu8WBvKcTtwmRH5NHm9JQ9GuyY8NmpnrPvH95_u_pUXX_9-Pnq3XXlFECu9n7wakBpwXvf9L1onKhBgxKidb0csNZQSwA9aABbXuu9q32PKIV2jfbqnL087l1i-Lliymai5HAc7YxhTaYHqSV08r9G2UDXCbUZm6Ox0Esp4mCWSJONv4wUZovHbOzNxt4AmL_xmLaMvTjtX_eF2v3QKY-iXx51LDRuCaNJjnB2BXAsCRkf6N8H_gDL-aCi</recordid><startdate>19880308</startdate><enddate>19880308</enddate><creator>Pehek, Elizabeth A.</creator><creator>Warner, Robert K.</creator><creator>Bazzett, Terence J.</creator><creator>Bitran, Daniel</creator><creator>Band, Linda C.</creator><creator>Eaton, Robert C.</creator><creator>Hull, Elaine M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880308</creationdate><title>Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats</title><author>Pehek, Elizabeth A. ; Warner, Robert K. ; Bazzett, Terence J. ; Bitran, Daniel ; Band, Linda C. ; Eaton, Robert C. ; Hull, Elaine M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-bdfd3fe1a8ddd47704c028983005c71fe29821889f988a3597dc2d7ee109c49d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Apomorphine</topic><topic>Apomorphine - pharmacology</topic><topic>cis-Flupenthixol</topic><topic>Copulation - drug effects</topic><topic>Dopamine</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Flupenthixol - administration & dosage</topic><topic>Flupenthixol - pharmacology</topic><topic>Male</topic><topic>Medial preoptic area</topic><topic>Microinjections</topic><topic>Ovariectomy</topic><topic>Preoptic Area - drug effects</topic><topic>Preoptic Area - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Thioxanthenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pehek, Elizabeth A.</creatorcontrib><creatorcontrib>Warner, Robert K.</creatorcontrib><creatorcontrib>Bazzett, Terence J.</creatorcontrib><creatorcontrib>Bitran, Daniel</creatorcontrib><creatorcontrib>Band, Linda C.</creatorcontrib><creatorcontrib>Eaton, Robert C.</creatorcontrib><creatorcontrib>Hull, Elaine M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pehek, Elizabeth A.</au><au>Warner, Robert K.</au><au>Bazzett, Terence J.</au><au>Bitran, Daniel</au><au>Band, Linda C.</au><au>Eaton, Robert C.</au><au>Hull, Elaine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-03-08</date><risdate>1988</risdate><volume>443</volume><issue>1</issue><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Systematically administered dopamine agonists have been shown to facilitate copulation in male rats. Microinjection of the dopamine agonist apomorphine into the medial preoptic area has also been reported to facilitate sexual behavior. The present experiments investigated the effects of medial preoptic microinjections of the dopamine antagonist
cis-flupenthixol on male rat copulatory behavior. Fewer males initiated copulation and fewer ejaculated following flupenthixol administration. Those males that did ejaculate following flupenthixol injections had fewer ejaculations and longer interintromission intervals. Flupenthixol also antagonized the facilitative effects of apomorphine injections into the medial preoptic area. Flupenthixol and apomorphine produced only minor alterations in non-copulatory behaviors. The results suggest that dopamine receptors within the medial preoptic area are important in the regulation of masculine sexual behavior in the rat.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3359281</pmid><doi>10.1016/0006-8993(88)91599-5</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Apomorphine Apomorphine - pharmacology cis-Flupenthixol Copulation - drug effects Dopamine Estradiol - pharmacology Female Flupenthixol - administration & dosage Flupenthixol - pharmacology Male Medial preoptic area Microinjections Ovariectomy Preoptic Area - drug effects Preoptic Area - physiology Rat Rats Sexual behavior Sexual Behavior, Animal - drug effects Thioxanthenes - pharmacology |
| title | Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats |
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