Ligand-dependent intersubunit association within the insulin receptor complex activates its intrinsic kinase activity

Insulin receptor halves (alpha beta) were obtained upon selective reduction of the holoreceptor (alpha 2 beta 2) and were isolated in concentrated form. Autophosphorylation of concentrated alpha beta receptor halves can be stimulated by insulin an average of 4.0-fold, whereas nonreduced holoreceptor...

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Veröffentlicht in:	The Journal of biological chemistry 1988-05, Vol.263 (14), p.6822-6828
Hauptverfasser:	Böni-Schnetzler, M, Kaligian, A, DelVecchio, R, Pilch, P F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell receptors Cell structures and functions Enzyme Activation Female Fundamental and applied biological sciences. Psychology Humans insulin Insulin - metabolism Kinetics Ligands Macromolecular Substances Maleimides - pharmacology Microsomes - metabolism Molecular and cellular biology Phosphorylation placenta Placenta - metabolism Pregnancy Protein-Tyrosine Kinases - metabolism Receptor, Insulin - isolation & purification Receptor, Insulin - metabolism
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