Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus
Objectives: Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established. Design and Methods: In our study Lp(a) was measured in a la...
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| Veröffentlicht in: | Clinical biochemistry 1996-06, Vol.29 (3), p.255-259 |
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| creator | Westerhuis, Lambertus W.J.J.M. Venekamp, Wim J.R.R. |
| description | Objectives: Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established.
Design and Methods: In our study Lp(a) was measured in a large group of diabetics (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.
Results: Statistically significant differences between Lp(a) levels in IDDM and NIDDM and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.
Conclusion: These results suggest that the level of Lp(a) in serum is not influenced by diabetes imellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy. |
| doi_str_mv | 10.1016/0009-9120(96)00002-5 |
| format | Article |
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Design and Methods: In our study Lp(a) was measured in a large group of diabetics (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.
Results: Statistically significant differences between Lp(a) levels in IDDM and NIDDM and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.
Conclusion: These results suggest that the level of Lp(a) in serum is not influenced by diabetes imellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/0009-9120(96)00002-5</identifier><identifier>PMID: 8740512</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Albuminuria - blood ; Albuminuria - metabolism ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic Neuropathies - blood ; Diabetic Neuropathies - metabolism ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - metabolism ; Female ; fructosamine ; Fructosamine - blood ; Fructosamine - metabolism ; HbA ; Hemoglobins - analysis ; Humans ; Lipoprotein(a) - blood ; Male ; microalbuminuria ; Middle Aged ; retino and/or neuropathy</subject><ispartof>Clinical biochemistry, 1996-06, Vol.29 (3), p.255-259</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-87c335e6758c49448d2c2226add789ba08b3057120109eed58730ea6b85429a43</citedby><cites>FETCH-LOGICAL-c357t-87c335e6758c49448d2c2226add789ba08b3057120109eed58730ea6b85429a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009912096000025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8740512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westerhuis, Lambertus W.J.J.M.</creatorcontrib><creatorcontrib>Venekamp, Wim J.R.R.</creatorcontrib><title>Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Objectives: Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established.
Design and Methods: In our study Lp(a) was measured in a large group of diabetics (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.
Results: Statistically significant differences between Lp(a) levels in IDDM and NIDDM and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.
Conclusion: These results suggest that the level of Lp(a) in serum is not influenced by diabetes imellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.</description><subject>Adult</subject><subject>Aged</subject><subject>Albuminuria - blood</subject><subject>Albuminuria - metabolism</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic Neuropathies - blood</subject><subject>Diabetic Neuropathies - metabolism</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - metabolism</subject><subject>Female</subject><subject>fructosamine</subject><subject>Fructosamine - blood</subject><subject>Fructosamine - metabolism</subject><subject>HbA</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>microalbuminuria</subject><subject>Middle Aged</subject><subject>retino and/or neuropathy</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9rHSEQxaU0pDdpv0ED-1SaBxN1dVdfAiU0fyCQh7TP4uqkGFy9UTeQb1-39zaPAWE4zJkZzw-hr5ScUUKHc0KIwooy8l0Np00QhsUHtKFy7DFTff8Rbd4sn9BRKU-rh8vhEB3KkRNB2QbND5CXuQt-m7Y5VfARmy7AC4TSmei6P-HVJjxDNVMK3nY2xZpT6Hxsryyh1dUWU8T_tYMtRAexds6bCSqUboYQfF3KZ3TwaEKBL_t6jH5f_fx1eYPv7q9vL3_cYduLsWI52r4XMIxCWq44l45ZxthgnBulmgyRU0_E2HJRogCcaJEJmGGSgjNleH-Mvu32tkzPC5SqZ19s-4SJkJaiR0ml5Ew0I98ZbU6lZHjU2-xnk181JXqlrFeEekWo1T9BmF7HTvb7l2kG9za0x9r6F7t-wwgvHrIu1kO04HwGW7VL_v0DfwEpU4xR</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Westerhuis, Lambertus W.J.J.M.</creator><creator>Venekamp, Wim J.R.R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus</title><author>Westerhuis, Lambertus W.J.J.M. ; Venekamp, Wim J.R.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-87c335e6758c49448d2c2226add789ba08b3057120109eed58730ea6b85429a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albuminuria - blood</topic><topic>Albuminuria - metabolism</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic Neuropathies - blood</topic><topic>Diabetic Neuropathies - metabolism</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - metabolism</topic><topic>Female</topic><topic>fructosamine</topic><topic>Fructosamine - blood</topic><topic>Fructosamine - metabolism</topic><topic>HbA</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>microalbuminuria</topic><topic>Middle Aged</topic><topic>retino and/or neuropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westerhuis, Lambertus W.J.J.M.</creatorcontrib><creatorcontrib>Venekamp, Wim J.R.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westerhuis, Lambertus W.J.J.M.</au><au>Venekamp, Wim J.R.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>29</volume><issue>3</issue><spage>255</spage><epage>259</epage><pages>255-259</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Objectives: Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established.
Design and Methods: In our study Lp(a) was measured in a large group of diabetics (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.
Results: Statistically significant differences between Lp(a) levels in IDDM and NIDDM and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.
Conclusion: These results suggest that the level of Lp(a) in serum is not influenced by diabetes imellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8740512</pmid><doi>10.1016/0009-9120(96)00002-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Albuminuria - blood Albuminuria - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetic Neuropathies - blood Diabetic Neuropathies - metabolism Diabetic Retinopathy - blood Diabetic Retinopathy - metabolism Female fructosamine Fructosamine - blood Fructosamine - metabolism HbA Hemoglobins - analysis Humans Lipoprotein(a) - blood Male microalbuminuria Middle Aged retino and/or neuropathy |
| title | Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus |
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