(-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus
GABA-mediated monosynaptic inhibitory postsynaptic currents were recorded at synapses between embryonic rat hippocampal neurons in culture. The GABAB receptor agonist L(-)-baclofen reduced inhibitory postsynaptic current amplitude substantially at 10 microM, while the D(+)-isomer of baclofen was wit...
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| Veröffentlicht in: | Neuroscience letters 1988-02, Vol.85 (1), p.105-109 |
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| container_title | Neuroscience letters |
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| creator | HARRISON, N. L LANGE, G. D BARKER, J. L |
| description | GABA-mediated monosynaptic inhibitory postsynaptic currents were recorded at synapses between embryonic rat hippocampal neurons in culture. The GABAB receptor agonist L(-)-baclofen reduced inhibitory postsynaptic current amplitude substantially at 10 microM, while the D(+)-isomer of baclofen was without effect. L(-)-Baclofen did not increase postsynaptic membrane conductance or block postsynaptic membrane responses to GABA. It is concluded that L(-)-baclofen depresses GABA-mediated inhibitory postsynaptic potentials by a presynaptic action at GABAB receptors on or near the terminals of the inhibitory neuron. The possible physiological importance of these presynaptic 'autoreceptors' is discussed. |
| doi_str_mv | 10.1016/0304-3940(88)90437-5 |
| format | Article |
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The possible physiological importance of these presynaptic 'autoreceptors' is discussed.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(88)90437-5</identifier><identifier>PMID: 2834671</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Action Potentials - drug effects ; Animals ; Baclofen - pharmacology ; Biological and medical sciences ; Cells, Cultured ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - metabolism ; gamma-Aminobutyric Acid - physiology ; Hippocampus - drug effects ; Hippocampus - embryology ; Hippocampus - physiology ; Membrane Potentials - drug effects ; Neural Inhibition - drug effects ; Rats ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1988-02, Vol.85 (1), p.105-109</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-aa198f3ef505de414835a646a8fd8ac1d836427f942bc261fff443f82d4608db3</citedby><cites>FETCH-LOGICAL-c331t-aa198f3ef505de414835a646a8fd8ac1d836427f942bc261fff443f82d4608db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7582179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2834671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARRISON, N. L</creatorcontrib><creatorcontrib>LANGE, G. D</creatorcontrib><creatorcontrib>BARKER, J. L</creatorcontrib><title>(-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>GABA-mediated monosynaptic inhibitory postsynaptic currents were recorded at synapses between embryonic rat hippocampal neurons in culture. The GABAB receptor agonist L(-)-baclofen reduced inhibitory postsynaptic current amplitude substantially at 10 microM, while the D(+)-isomer of baclofen was without effect. L(-)-Baclofen did not increase postsynaptic membrane conductance or block postsynaptic membrane responses to GABA. It is concluded that L(-)-baclofen depresses GABA-mediated inhibitory postsynaptic potentials by a presynaptic action at GABAB receptors on or near the terminals of the inhibitory neuron. The possible physiological importance of these presynaptic 'autoreceptors' is discussed.</description><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Baclofen - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - embryology</subject><subject>Hippocampus - physiology</subject><subject>Membrane Potentials - drug effects</subject><subject>Neural Inhibition - drug effects</subject><subject>Rats</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-A - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKxDAURYMoOo7-gUIWIrqoJk3apMuZQUdBcKPr8JomGmmTmrTC_L0dHWb14N5z3-IgdEHJHSW0vCeM8IxVnNxIeVsRzkRWHKAZlSLPRCXyQzTbIyfoNKUvQkhBC36MjnPJeCnoDH3fZLfZEnQbrPEY9OB-YDAJ99GkjYd-cBqvF8vFEkejTT-EmHDwf5GJH1Pp_Ker3ZRvsDdjDD5hG0OHTVfHTfATEWHAn67vg4auH9MZOrLQJnO-u3P0_vjwtnrKXl7Xz6vFS6YZo0MGQCtpmbEFKRrDKZesgJKXIG0jQdNGspLnwlY8r3VeUmst58zKvOElkU3N5uj6_28fw_do0qA6l7RpW_AmjEkJOZkiZTGB_B_UMaQUjVV9dB3EjaJEbU2rrUa11aikVH-m1XZ2ufs_1p1p9qOd2qm_2vWQNLQ2gtcu7TFRyJyKiv0Csc2GnA</recordid><startdate>19880215</startdate><enddate>19880215</enddate><creator>HARRISON, N. L</creator><creator>LANGE, G. D</creator><creator>BARKER, J. L</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880215</creationdate><title>(-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus</title><author>HARRISON, N. L ; LANGE, G. D ; BARKER, J. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-aa198f3ef505de414835a646a8fd8ac1d836427f942bc261fff443f82d4608db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Baclofen - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - embryology</topic><topic>Hippocampus - physiology</topic><topic>Membrane Potentials - drug effects</topic><topic>Neural Inhibition - drug effects</topic><topic>Rats</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARRISON, N. L</creatorcontrib><creatorcontrib>LANGE, G. D</creatorcontrib><creatorcontrib>BARKER, J. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1988-02-15</date><risdate>1988</risdate><volume>85</volume><issue>1</issue><spage>105</spage><epage>109</epage><pages>105-109</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>GABA-mediated monosynaptic inhibitory postsynaptic currents were recorded at synapses between embryonic rat hippocampal neurons in culture. The GABAB receptor agonist L(-)-baclofen reduced inhibitory postsynaptic current amplitude substantially at 10 microM, while the D(+)-isomer of baclofen was without effect. L(-)-Baclofen did not increase postsynaptic membrane conductance or block postsynaptic membrane responses to GABA. It is concluded that L(-)-baclofen depresses GABA-mediated inhibitory postsynaptic potentials by a presynaptic action at GABAB receptors on or near the terminals of the inhibitory neuron. The possible physiological importance of these presynaptic 'autoreceptors' is discussed.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>2834671</pmid><doi>10.1016/0304-3940(88)90437-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1988-02, Vol.85 (1), p.105-109 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Action Potentials - drug effects Animals Baclofen - pharmacology Biological and medical sciences Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electric Stimulation Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - physiology Hippocampus - drug effects Hippocampus - embryology Hippocampus - physiology Membrane Potentials - drug effects Neural Inhibition - drug effects Rats Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Vertebrates: nervous system and sense organs |
| title | (-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus |
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