Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region
Objectives: To investigate the presence of ret and trk proto-oncogene rearrangements in thyroid tumors. Design and Methods: High- molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 Lymph node metastasis of a papillary...
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| Veröffentlicht in: | Clinical biochemistry 1996-06, Vol.29 (3), p.267-271 |
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| container_title | Clinical biochemistry |
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| creator | Delvincourt, Chantal Patey, Martine Flament, Jean Bernard Suarez, Horacio G. Larbre, Helene Jardillier, Jean Claude Delisle, Marie Joelle |
| description | Objectives: To investigate the presence of
ret and
trk proto-oncogene rearrangements in thyroid tumors.
Design and Methods: High- molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 Lymph node metastasis of a papillary carcinoma, 1 follicular carcinoma, and 3 medullary carcinomas) and 22 adjacent tissues. Southern blot analysis was performed after digestion with EcoR1 or BamH1, using specific probes for
ret and
trk.
Results: Only 2
ret rearrangements were found in 2 papillary carcinomas (overall frequency: 6%; papillary carcinoma frequency: 13%). All normal or tumor samples were negative for the presence of a
trk rearrangement.
Conclusions: The previous data from the literature are highly conflicting, ranging from 0 to 30% of activation. Our results could be, therefore, classified as medium between these extreme values. It seems, therefore, that genetic and/or geographical factors could play a role in
ret and
trk proto-oncogene activation. |
| doi_str_mv | 10.1016/0009-9120(96)00006-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78186241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0009912096000069</els_id><sourcerecordid>78186241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-71a7c8b2ded61418ff21988ec80e81a48607a08d47f73e9d578775a632c4698c3</originalsourceid><addsrcrecordid>eNp9UMtKAzEUDaLUWv0DhaxEF6PJzDSPjSDiCwRBdB1icqeNdpIxSQX9elNbXLq6HM7jcg5Ch5ScUULZOSFEVpLW5ESy0wIIq-QWGlPBm6qWTbONxn-SXbSX0luBdSvYCI0Eb8mUtmP0_QQZa29xju94iCGHKngTZuABa5Pdp84ueOw8zvOvGJzFgx7cYqHjFzY6GudDr9OK7yJ4My90duBzKjj0xQTYzHU_6JmHSkcLvgRHmJXQfbTT6UWCg82doJeb6-eru-rh8fb-6vKhMs2U54pTzY14rS1YRlsquq6mUggwgoCguvQhXBNhW97xBqSdcsH5VLOmNi2TwjQTdLzOLfU-lpCy6l0yUDp4CMukuKCC1S0twnYtNDGkFKFTQ3R9aaooUavJ1WpPtdpTyV9AmJLFdrTJX772YP9Mm40Lf7HmoZT8dBBVMmUiA9ZFMFnZ4P5_8AMIp5GR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78186241</pqid></control><display><type>article</type><title>Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Delvincourt, Chantal ; Patey, Martine ; Flament, Jean Bernard ; Suarez, Horacio G. ; Larbre, Helene ; Jardillier, Jean Claude ; Delisle, Marie Joelle</creator><creatorcontrib>Delvincourt, Chantal ; Patey, Martine ; Flament, Jean Bernard ; Suarez, Horacio G. ; Larbre, Helene ; Jardillier, Jean Claude ; Delisle, Marie Joelle</creatorcontrib><description>Objectives: To investigate the presence of
ret and
trk proto-oncogene rearrangements in thyroid tumors.
Design and Methods: High- molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 Lymph node metastasis of a papillary carcinoma, 1 follicular carcinoma, and 3 medullary carcinomas) and 22 adjacent tissues. Southern blot analysis was performed after digestion with EcoR1 or BamH1, using specific probes for
ret and
trk.
Results: Only 2
ret rearrangements were found in 2 papillary carcinomas (overall frequency: 6%; papillary carcinoma frequency: 13%). All normal or tumor samples were negative for the presence of a
trk rearrangement.
Conclusions: The previous data from the literature are highly conflicting, ranging from 0 to 30% of activation. Our results could be, therefore, classified as medium between these extreme values. It seems, therefore, that genetic and/or geographical factors could play a role in
ret and
trk proto-oncogene activation.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/0009-9120(96)00006-9</identifier><identifier>PMID: 8740514</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Blotting, Southern ; Carcinoma, Papillary - epidemiology ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - pathology ; Drosophila Proteins ; Female ; France ; Gene Expression Regulation, Neoplastic ; Gene Rearrangement ; Humans ; Male ; Middle Aged ; proto-oncogene activation ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor, trkA ; Receptors, Nerve Growth Factor - genetics ; ret ; thyroid carcinoma ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology ; trk</subject><ispartof>Clinical biochemistry, 1996-06, Vol.29 (3), p.267-271</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-71a7c8b2ded61418ff21988ec80e81a48607a08d47f73e9d578775a632c4698c3</citedby><cites>FETCH-LOGICAL-c357t-71a7c8b2ded61418ff21988ec80e81a48607a08d47f73e9d578775a632c4698c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009912096000069$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8740514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delvincourt, Chantal</creatorcontrib><creatorcontrib>Patey, Martine</creatorcontrib><creatorcontrib>Flament, Jean Bernard</creatorcontrib><creatorcontrib>Suarez, Horacio G.</creatorcontrib><creatorcontrib>Larbre, Helene</creatorcontrib><creatorcontrib>Jardillier, Jean Claude</creatorcontrib><creatorcontrib>Delisle, Marie Joelle</creatorcontrib><title>Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Objectives: To investigate the presence of
ret and
trk proto-oncogene rearrangements in thyroid tumors.
Design and Methods: High- molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 Lymph node metastasis of a papillary carcinoma, 1 follicular carcinoma, and 3 medullary carcinomas) and 22 adjacent tissues. Southern blot analysis was performed after digestion with EcoR1 or BamH1, using specific probes for
ret and
trk.
Results: Only 2
ret rearrangements were found in 2 papillary carcinomas (overall frequency: 6%; papillary carcinoma frequency: 13%). All normal or tumor samples were negative for the presence of a
trk rearrangement.
Conclusions: The previous data from the literature are highly conflicting, ranging from 0 to 30% of activation. Our results could be, therefore, classified as medium between these extreme values. It seems, therefore, that genetic and/or geographical factors could play a role in
ret and
trk proto-oncogene activation.</description><subject>Adult</subject><subject>Aged</subject><subject>Blotting, Southern</subject><subject>Carcinoma, Papillary - epidemiology</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Drosophila Proteins</subject><subject>Female</subject><subject>France</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Rearrangement</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>proto-oncogene activation</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-ret</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor, trkA</subject><subject>Receptors, Nerve Growth Factor - genetics</subject><subject>ret</subject><subject>thyroid carcinoma</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><subject>trk</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKAzEUDaLUWv0DhaxEF6PJzDSPjSDiCwRBdB1icqeNdpIxSQX9elNbXLq6HM7jcg5Ch5ScUULZOSFEVpLW5ESy0wIIq-QWGlPBm6qWTbONxn-SXbSX0luBdSvYCI0Eb8mUtmP0_QQZa29xju94iCGHKngTZuABa5Pdp84ueOw8zvOvGJzFgx7cYqHjFzY6GudDr9OK7yJ4My90duBzKjj0xQTYzHU_6JmHSkcLvgRHmJXQfbTT6UWCg82doJeb6-eru-rh8fb-6vKhMs2U54pTzY14rS1YRlsquq6mUggwgoCguvQhXBNhW97xBqSdcsH5VLOmNi2TwjQTdLzOLfU-lpCy6l0yUDp4CMukuKCC1S0twnYtNDGkFKFTQ3R9aaooUavJ1WpPtdpTyV9AmJLFdrTJX772YP9Mm40Lf7HmoZT8dBBVMmUiA9ZFMFnZ4P5_8AMIp5GR</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Delvincourt, Chantal</creator><creator>Patey, Martine</creator><creator>Flament, Jean Bernard</creator><creator>Suarez, Horacio G.</creator><creator>Larbre, Helene</creator><creator>Jardillier, Jean Claude</creator><creator>Delisle, Marie Joelle</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region</title><author>Delvincourt, Chantal ; Patey, Martine ; Flament, Jean Bernard ; Suarez, Horacio G. ; Larbre, Helene ; Jardillier, Jean Claude ; Delisle, Marie Joelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-71a7c8b2ded61418ff21988ec80e81a48607a08d47f73e9d578775a632c4698c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blotting, Southern</topic><topic>Carcinoma, Papillary - epidemiology</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Drosophila Proteins</topic><topic>Female</topic><topic>France</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Rearrangement</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>proto-oncogene activation</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins c-ret</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor, trkA</topic><topic>Receptors, Nerve Growth Factor - genetics</topic><topic>ret</topic><topic>thyroid carcinoma</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - pathology</topic><topic>trk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delvincourt, Chantal</creatorcontrib><creatorcontrib>Patey, Martine</creatorcontrib><creatorcontrib>Flament, Jean Bernard</creatorcontrib><creatorcontrib>Suarez, Horacio G.</creatorcontrib><creatorcontrib>Larbre, Helene</creatorcontrib><creatorcontrib>Jardillier, Jean Claude</creatorcontrib><creatorcontrib>Delisle, Marie Joelle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delvincourt, Chantal</au><au>Patey, Martine</au><au>Flament, Jean Bernard</au><au>Suarez, Horacio G.</au><au>Larbre, Helene</au><au>Jardillier, Jean Claude</au><au>Delisle, Marie Joelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>29</volume><issue>3</issue><spage>267</spage><epage>271</epage><pages>267-271</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Objectives: To investigate the presence of
ret and
trk proto-oncogene rearrangements in thyroid tumors.
Design and Methods: High- molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 Lymph node metastasis of a papillary carcinoma, 1 follicular carcinoma, and 3 medullary carcinomas) and 22 adjacent tissues. Southern blot analysis was performed after digestion with EcoR1 or BamH1, using specific probes for
ret and
trk.
Results: Only 2
ret rearrangements were found in 2 papillary carcinomas (overall frequency: 6%; papillary carcinoma frequency: 13%). All normal or tumor samples were negative for the presence of a
trk rearrangement.
Conclusions: The previous data from the literature are highly conflicting, ranging from 0 to 30% of activation. Our results could be, therefore, classified as medium between these extreme values. It seems, therefore, that genetic and/or geographical factors could play a role in
ret and
trk proto-oncogene activation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8740514</pmid><doi>10.1016/0009-9120(96)00006-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 1996-06, Vol.29 (3), p.267-271 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78186241 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Blotting, Southern Carcinoma, Papillary - epidemiology Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Drosophila Proteins Female France Gene Expression Regulation, Neoplastic Gene Rearrangement Humans Male Middle Aged proto-oncogene activation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics Receptor, trkA Receptors, Nerve Growth Factor - genetics ret thyroid carcinoma Thyroid Neoplasms - epidemiology Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology trk |
| title | Ret and trk proto-oncogene activation in thyroid papillary carcinomas in french patients from the champagne-ardenne region |
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