Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock
Volume infusion, to increase preload and to enhance ventricular performance, is accepted as initial management of septic shock. Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance during volume infusion using serial data from...
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| Veröffentlicht in: | Chest 1988-05, Vol.93 (5), p.903-910 |
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| creator | OGNIBENE, F. P PARKER, M. M NATANSON, C SHELHAMER, J. H PARRILLO, J. E |
| description | Volume infusion, to increase preload and to enhance ventricular performance, is accepted as initial management of septic shock.
Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance
during volume infusion using serial data from simultaneously obtained pulmonary artery catheter hemodynamic measurements and
radionuclide cineangiography. Critically ill control subjects (n = 14), patients with sepsis but without shock (n = 21), and
patients with septic shock (n = 21) had prevolume infusion hemodynamic measurements determined and received statistically
similar volumes of fluid resulting in similar increases in pulmonary capillary wedge pressure. There was a strong trend (p
= 0.004) toward less of a change in left ventricular stroke work index (LVSWI) after volume infusion in patients with sepsis
and septic shock compared with control subjects. The LVSWI response after volume infusion was significantly less in patients
with septic shock when compared with critically ill control subjects (p less than 0.05). These data demonstrate significantly
altered ventricular performance, as measured by LVSWI, in response to volume infusion in patients with septic shock. |
| doi_str_mv | 10.1378/chest.93.5.903 |
| format | Article |
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Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance
during volume infusion using serial data from simultaneously obtained pulmonary artery catheter hemodynamic measurements and
radionuclide cineangiography. Critically ill control subjects (n = 14), patients with sepsis but without shock (n = 21), and
patients with septic shock (n = 21) had prevolume infusion hemodynamic measurements determined and received statistically
similar volumes of fluid resulting in similar increases in pulmonary capillary wedge pressure. There was a strong trend (p
= 0.004) toward less of a change in left ventricular stroke work index (LVSWI) after volume infusion in patients with sepsis
and septic shock compared with control subjects. The LVSWI response after volume infusion was significantly less in patients
with septic shock when compared with critically ill control subjects (p less than 0.05). These data demonstrate significantly
altered ventricular performance, as measured by LVSWI, in response to volume infusion in patients with septic shock.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.93.5.903</identifier><identifier>PMID: 3359845</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Critical Care ; Emergency and intensive care: infection, septic shock ; Erythrocytes ; Fluid Therapy ; Heart - diagnostic imaging ; Heart - physiopathology ; Hemodynamics ; Humans ; Infection - physiopathology ; Infection - therapy ; Intensive care medicine ; Medical sciences ; Myocardial Contraction ; Radionuclide Imaging ; Shock, Septic - physiopathology ; Shock, Septic - therapy ; Sodium Chloride - therapeutic use ; Stroke Volume ; Technetium</subject><ispartof>Chest, 1988-05, Vol.93 (5), p.903-910</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7653640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3359845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGNIBENE, F. P</creatorcontrib><creatorcontrib>PARKER, M. M</creatorcontrib><creatorcontrib>NATANSON, C</creatorcontrib><creatorcontrib>SHELHAMER, J. H</creatorcontrib><creatorcontrib>PARRILLO, J. E</creatorcontrib><title>Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock</title><title>Chest</title><addtitle>Chest</addtitle><description>Volume infusion, to increase preload and to enhance ventricular performance, is accepted as initial management of septic shock.
Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance
during volume infusion using serial data from simultaneously obtained pulmonary artery catheter hemodynamic measurements and
radionuclide cineangiography. Critically ill control subjects (n = 14), patients with sepsis but without shock (n = 21), and
patients with septic shock (n = 21) had prevolume infusion hemodynamic measurements determined and received statistically
similar volumes of fluid resulting in similar increases in pulmonary capillary wedge pressure. There was a strong trend (p
= 0.004) toward less of a change in left ventricular stroke work index (LVSWI) after volume infusion in patients with sepsis
and septic shock compared with control subjects. The LVSWI response after volume infusion was significantly less in patients
with septic shock when compared with critically ill control subjects (p less than 0.05). These data demonstrate significantly
altered ventricular performance, as measured by LVSWI, in response to volume infusion in patients with septic shock.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Critical Care</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Erythrocytes</subject><subject>Fluid Therapy</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiopathology</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Infection - physiopathology</subject><subject>Infection - therapy</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Myocardial Contraction</subject><subject>Radionuclide Imaging</subject><subject>Shock, Septic - physiopathology</subject><subject>Shock, Septic - therapy</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Stroke Volume</subject><subject>Technetium</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1v1jAMxiMEGi-DKzekHBC3dkndJM0RjU9p0iQ0zlWa16UZaVPidtP-ezL2ipMfyz9b9mPG3kpRSzDdhZ-QttpCrWor4Bk7SAuyAtXCc3YQQjYVaNu8ZK-IbkXJpdVn7AxA2a5VBxY_4ZqRCI884rjxO1y2HPweXeYr5jHl2S0ea_4DaU0LId8Sv0txn5GHZdwppKUIvrotlFbi92GbOOFKgbhbjo9yC57TlPzv1-zF6CLhm1M8Zz-_fL65_FZdXX_9fvnxqpoa026VEq0pt7UdyMEIjaYZjDLtiE4OErzWoFsxKusGkIgGzOAAnW_M0QrTNALO2YenuWtOf_biTz8H8hijWzDt1JtOdlpoW8B3J3AfZjz2aw6zyw_9yZ5Sf3-qO_Iujrl4Eeg_ZrR6XKVg9RM2hV_TfcjY0-xiLEOh__ef27TnxUULverLl-AvG3WF8A</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>OGNIBENE, F. P</creator><creator>PARKER, M. M</creator><creator>NATANSON, C</creator><creator>SHELHAMER, J. H</creator><creator>PARRILLO, J. E</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock</title><author>OGNIBENE, F. P ; PARKER, M. M ; NATANSON, C ; SHELHAMER, J. H ; PARRILLO, J. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h274t-50471374831b706e72b7574fea1b13c663640f59ab31ee737ba3eac27d9072203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Critical Care</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Erythrocytes</topic><topic>Fluid Therapy</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - physiopathology</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Infection - physiopathology</topic><topic>Infection - therapy</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Myocardial Contraction</topic><topic>Radionuclide Imaging</topic><topic>Shock, Septic - physiopathology</topic><topic>Shock, Septic - therapy</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Stroke Volume</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OGNIBENE, F. P</creatorcontrib><creatorcontrib>PARKER, M. M</creatorcontrib><creatorcontrib>NATANSON, C</creatorcontrib><creatorcontrib>SHELHAMER, J. H</creatorcontrib><creatorcontrib>PARRILLO, J. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGNIBENE, F. P</au><au>PARKER, M. M</au><au>NATANSON, C</au><au>SHELHAMER, J. H</au><au>PARRILLO, J. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>93</volume><issue>5</issue><spage>903</spage><epage>910</epage><pages>903-910</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Volume infusion, to increase preload and to enhance ventricular performance, is accepted as initial management of septic shock.
Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance
during volume infusion using serial data from simultaneously obtained pulmonary artery catheter hemodynamic measurements and
radionuclide cineangiography. Critically ill control subjects (n = 14), patients with sepsis but without shock (n = 21), and
patients with septic shock (n = 21) had prevolume infusion hemodynamic measurements determined and received statistically
similar volumes of fluid resulting in similar increases in pulmonary capillary wedge pressure. There was a strong trend (p
= 0.004) toward less of a change in left ventricular stroke work index (LVSWI) after volume infusion in patients with sepsis
and septic shock compared with control subjects. The LVSWI response after volume infusion was significantly less in patients
with septic shock when compared with critically ill control subjects (p less than 0.05). These data demonstrate significantly
altered ventricular performance, as measured by LVSWI, in response to volume infusion in patients with septic shock.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>3359845</pmid><doi>10.1378/chest.93.5.903</doi><tpages>8</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Critical Care Emergency and intensive care: infection, septic shock Erythrocytes Fluid Therapy Heart - diagnostic imaging Heart - physiopathology Hemodynamics Humans Infection - physiopathology Infection - therapy Intensive care medicine Medical sciences Myocardial Contraction Radionuclide Imaging Shock, Septic - physiopathology Shock, Septic - therapy Sodium Chloride - therapeutic use Stroke Volume Technetium |
| title | Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock |
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