Pertussis Toxin-Treated Dog: A Whole Animal Model of Impaired Inhibitory Regulation of Adenylate Cyclase

We have shown previously that stimulation of high-affinity GTP hydrolysis and inhibition of adenylate cyclase activity by muscarinic agonists are mediated by pertussis toxin (IAP) substrates (G1 and G0in canine cardiac sarcolemma. We have now used the pertussis toxin-treated dog as a whole animal mo...

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Veröffentlicht in:	Circulation research 1988-05, Vol.62 (5), p.992-1000
Hauptverfasser:	Fleming, John W, Hodges, Timothy D, Watanabe, August M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin Adenylyl Cyclase Inhibitors Adenylyl Cyclases - metabolism Animals Biological and medical sciences Cardiology. Vascular system Dogs Medical sciences Models, Biological Oxotremorine - metabolism Pertussis Toxin Sarcolemma - drug effects Virulence Factors, Bordetella - pharmacology
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