Increased bone formation in osteocalcin-deficient mice
VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new bone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A few molecular determinants of bone remodelling that affect osteoclast activity 1–3 have been char...
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| Veröffentlicht in: | Nature (London) 1996-08, Vol.382 (6590), p.448-452 |
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| creator | Ducy, Patricia Desbois, Christelle Boyce, Brendan Pinero, Gerald Story, Beryl Dunstan, Colin Smith, Erica Bonadio, Jeffrey Goldstein, Steven Gundberg, Caren Bradley, Allan Karsenty, Gerard |
| description | VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new bone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A few molecular determinants of bone remodelling that affect osteoclast activity
1–3
have been characterized, but the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein
4
, we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation. |
| doi_str_mv | 10.1038/382448a0 |
| format | Article |
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1–3
have been characterized, but the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein
4
, we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/382448a0</identifier><identifier>PMID: 8684484</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - anatomy & histology ; Bone and Bones - diagnostic imaging ; Bone and Bones - physiology ; Bone Development - physiology ; Bone Remodeling - physiology ; Bone Resorption ; Bones ; Calcification, Physiologic ; Cell Line ; Classical genetics, quantitative genetics, hybrids ; Crosses, Genetic ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Targeting ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Humanities and Social Sciences ; letter ; Male ; Mice ; Mice, Inbred C57BL ; multidisciplinary ; Mutation ; Osteocalcin - deficiency ; Osteocalcin - genetics ; Osteocalcin - physiology ; Proteins ; Radiography ; Rodents ; Science ; Science (multidisciplinary) ; Space life sciences ; Tetracycline ; Vertebrata</subject><ispartof>Nature (London), 1996-08, Vol.382 (6590), p.448-452</ispartof><rights>Springer Nature Limited 1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Aug 1, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-c940010e4f046d88c1119e1f358a190f6a2522b0b7b9f4021b7723cace033ab33</citedby><cites>FETCH-LOGICAL-c533t-c940010e4f046d88c1119e1f358a190f6a2522b0b7b9f4021b7723cace033ab33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/382448a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/382448a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3167101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8684484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ducy, Patricia</creatorcontrib><creatorcontrib>Desbois, Christelle</creatorcontrib><creatorcontrib>Boyce, Brendan</creatorcontrib><creatorcontrib>Pinero, Gerald</creatorcontrib><creatorcontrib>Story, Beryl</creatorcontrib><creatorcontrib>Dunstan, Colin</creatorcontrib><creatorcontrib>Smith, Erica</creatorcontrib><creatorcontrib>Bonadio, Jeffrey</creatorcontrib><creatorcontrib>Goldstein, Steven</creatorcontrib><creatorcontrib>Gundberg, Caren</creatorcontrib><creatorcontrib>Bradley, Allan</creatorcontrib><creatorcontrib>Karsenty, Gerard</creatorcontrib><title>Increased bone formation in osteocalcin-deficient mice</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new bone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A few molecular determinants of bone remodelling that affect osteoclast activity
1–3
have been characterized, but the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein
4
, we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - physiology</subject><subject>Bone Development - physiology</subject><subject>Bone Remodeling - physiology</subject><subject>Bone Resorption</subject><subject>Bones</subject><subject>Calcification, Physiologic</subject><subject>Cell Line</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Targeting</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>multidisciplinary</subject><subject>Mutation</subject><subject>Osteocalcin - deficiency</subject><subject>Osteocalcin - genetics</subject><subject>Osteocalcin - physiology</subject><subject>Proteins</subject><subject>Radiography</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Space life sciences</subject><subject>Tetracycline</subject><subject>Vertebrata</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0U1LJDEQBuAgLjo7K_gHhEZkPw6tVUk6nT6K6K4g7GX33KQzFYlMJ5r0HPz3ZphRQUFPOdRDpapexg4RThGEPhOaS6kN7LAZylbVUul2l80AuK5BC7XPvuZ8BwANtnKP7Wmli5czpq6DTWQyLaohBqpcTKOZfAyVD1XME0VrltaHekHOW09hqkZv6Rv74swy08H2nbP_V5f_Lv7UN39_X1-c39S2EWKqbScBEEg6kGqhtUXEjtCJRhvswCnDG84HGNqhcxI4Dm3LhTWWQAgzCDFn3zd971N8WFGe-tFnS8ulCRRXuW816gYVFvjjYyiFQNUK-LQlNk2HSjcFHr-Bd3GVQlm35yClElzpgn5ukE0x50Suv09-NOmxR-jX0fTP0RR6tO23GkZavMBtFqV-sq2bXI7ukgnW5xe2Hh9hvemvDculEm4pvY717ssnwRCfGw</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Ducy, Patricia</creator><creator>Desbois, Christelle</creator><creator>Boyce, Brendan</creator><creator>Pinero, Gerald</creator><creator>Story, Beryl</creator><creator>Dunstan, Colin</creator><creator>Smith, Erica</creator><creator>Bonadio, Jeffrey</creator><creator>Goldstein, Steven</creator><creator>Gundberg, Caren</creator><creator>Bradley, Allan</creator><creator>Karsenty, Gerard</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Increased bone formation in osteocalcin-deficient mice</title><author>Ducy, Patricia ; 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ducy, Patricia</au><au>Desbois, Christelle</au><au>Boyce, Brendan</au><au>Pinero, Gerald</au><au>Story, Beryl</au><au>Dunstan, Colin</au><au>Smith, Erica</au><au>Bonadio, Jeffrey</au><au>Goldstein, Steven</au><au>Gundberg, Caren</au><au>Bradley, Allan</au><au>Karsenty, Gerard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased bone formation in osteocalcin-deficient mice</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>382</volume><issue>6590</issue><spage>448</spage><epage>452</epage><pages>448-452</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new bone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A few molecular determinants of bone remodelling that affect osteoclast activity
1–3
have been characterized, but the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein
4
, we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8684484</pmid><doi>10.1038/382448a0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-08, Vol.382 (6590), p.448-452 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Animals Biological and medical sciences Bone and Bones - anatomy & histology Bone and Bones - diagnostic imaging Bone and Bones - physiology Bone Development - physiology Bone Remodeling - physiology Bone Resorption Bones Calcification, Physiologic Cell Line Classical genetics, quantitative genetics, hybrids Crosses, Genetic Female Fundamental and applied biological sciences. Psychology Gene Targeting Genetics Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences letter Male Mice Mice, Inbred C57BL multidisciplinary Mutation Osteocalcin - deficiency Osteocalcin - genetics Osteocalcin - physiology Proteins Radiography Rodents Science Science (multidisciplinary) Space life sciences Tetracycline Vertebrata |
| title | Increased bone formation in osteocalcin-deficient mice |
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