Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits
Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-der...
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| Veröffentlicht in: | Medical & biological engineering & computing 1996-05, Vol.34 (3), p.227-231 |
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| container_title | Medical & biological engineering & computing |
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| creator | BRAY, R FORRESTER, K MCDOUGALL, J. J DAMJI, A FERRELL, W. R |
| description | Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed. |
| doi_str_mv | 10.1007/bf02520078 |
| format | Article |
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J ; DAMJI, A ; FERRELL, W. R</creator><creatorcontrib>BRAY, R ; FORRESTER, K ; MCDOUGALL, J. J ; DAMJI, A ; FERRELL, W. R</creatorcontrib><description>Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/bf02520078</identifier><identifier>PMID: 8762830</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Female ; Investigative techniques, diagnostic techniques (general aspects) ; Joints ; Knee Injuries - physiopathology ; Knee Joint - blood supply ; Laser-Doppler Flowmetry - methods ; Ligaments, Articular - blood supply ; Ligaments, Articular - injuries ; Medical sciences ; Rabbits ; Regional Blood Flow ; Ultrasonic investigative techniques</subject><ispartof>Medical & biological engineering & computing, 1996-05, Vol.34 (3), p.227-231</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-f67677fa062d149411e34410c015ab96cbb228bbbc7d67492b27fb3ceaec16b43</citedby><cites>FETCH-LOGICAL-c377t-f67677fa062d149411e34410c015ab96cbb228bbbc7d67492b27fb3ceaec16b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3120436$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8762830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRAY, R</creatorcontrib><creatorcontrib>FORRESTER, K</creatorcontrib><creatorcontrib>MCDOUGALL, J. J</creatorcontrib><creatorcontrib>DAMJI, A</creatorcontrib><creatorcontrib>FERRELL, W. R</creatorcontrib><title>Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><description>Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Joints</subject><subject>Knee Injuries - physiopathology</subject><subject>Knee Joint - blood supply</subject><subject>Laser-Doppler Flowmetry - methods</subject><subject>Ligaments, Articular - blood supply</subject><subject>Ligaments, Articular - injuries</subject><subject>Medical sciences</subject><subject>Rabbits</subject><subject>Regional Blood Flow</subject><subject>Ultrasonic investigative techniques</subject><issn>0140-0118</issn><issn>1741-0444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFLwzAUxoMoc04v3oUcxINQfS_Nmu6oc1Nh4EVvQknSZFTTpiat4n9vx-ZO34PvxwfvR8g5wg0CiFtlgU3ZcOUHZIyCYwKc80MyBuSQAGJ-TE5i_ABgOGV8REa5yFiewpi8L76l62VX-YZ6S52MJtAH37ZuyKqW66pZ087T2sjYB0OV876k1vkfWjX0szGGumota9N0cTMgy951NEilqi6ekiMrXTRnu5yQt-Xidf6UrF4en-d3q0SnQnSJzUQmhJWQsRL5jCOalHMEDTiVapZppRjLlVJalJngM6aYsCrVRhqNmeLphFxtd9vgv3oTu6KuojbOycb4PhYix5xzEAN4vQV18DEGY4s2DE-G3wKh2Kgs7pf_Kgf4Yrfaq9qUe3Tnbugvd72MWjobZKOruMdSZMDTLP0DM7p60Q</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>BRAY, R</creator><creator>FORRESTER, K</creator><creator>MCDOUGALL, J. 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J</creatorcontrib><creatorcontrib>DAMJI, A</creatorcontrib><creatorcontrib>FERRELL, W. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical & biological engineering & computing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRAY, R</au><au>FORRESTER, K</au><au>MCDOUGALL, J. J</au><au>DAMJI, A</au><au>FERRELL, W. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits</atitle><jtitle>Medical & biological engineering & computing</jtitle><addtitle>Med Biol Eng Comput</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>34</volume><issue>3</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8762830</pmid><doi>10.1007/bf02520078</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-0118 |
| ispartof | Medical & biological engineering & computing, 1996-05, Vol.34 (3), p.227-231 |
| issn | 0140-0118 1741-0444 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Female Investigative techniques, diagnostic techniques (general aspects) Joints Knee Injuries - physiopathology Knee Joint - blood supply Laser-Doppler Flowmetry - methods Ligaments, Articular - blood supply Ligaments, Articular - injuries Medical sciences Rabbits Regional Blood Flow Ultrasonic investigative techniques |
| title | Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits |
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