Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles
To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles. Retrospective study. Sixty-four infertile patients with varicoceles. A university-based tertiary care referral center. Assessment of seminal cellular characteristics, gonadotropin resp...
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| Veröffentlicht in: | Fertility and sterility 1996-08, Vol.66 (2), p.299-304 |
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| creator | Hudson, Robert W. |
| description | To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles.
Retrospective study.
Sixty-four infertile patients with varicoceles.
A university-based tertiary care referral center.
Assessment of seminal cellular characteristics, gonadotropin responses to GnRH, total and free T, and E2 and SHBG levels before and after varicocele ligation.
Thirty-eight men had excessive preoperative gonadotropin responses to GnRH. These men had lower than normal levels of free T and higher than normal levels of free E2 and SHBG. Thirty men had improvements in seminal parameters, and sex steroid and SHBG values after surgery. Seven spontaneous pregnancies and three pregnancies through IUI occurred in their partners postoperatively. Twenty-six men had normal preoperative responses to GnRH and normal free T, E2, and SHBG levels. None had postoperative improvements in their semen analyses and no spontaneous pregnancies occurred in their partners. Three pregnancies occurred with IUI.
The men with excessive responses to GnRH had abnormal free sex steroid levels. The majority had improvements in semen analyses after varicocele repair and pregnancies occurred in their partners. The men with normal gonadotropin responses to GnRH had normal free sex steroid levels. Varicocele ligation had no effect on their semen parameters or fertility potential. |
| doi_str_mv | 10.1016/S0015-0282(16)58457-X |
| format | Article |
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Retrospective study.
Sixty-four infertile patients with varicoceles.
A university-based tertiary care referral center.
Assessment of seminal cellular characteristics, gonadotropin responses to GnRH, total and free T, and E2 and SHBG levels before and after varicocele ligation.
Thirty-eight men had excessive preoperative gonadotropin responses to GnRH. These men had lower than normal levels of free T and higher than normal levels of free E2 and SHBG. Thirty men had improvements in seminal parameters, and sex steroid and SHBG values after surgery. Seven spontaneous pregnancies and three pregnancies through IUI occurred in their partners postoperatively. Twenty-six men had normal preoperative responses to GnRH and normal free T, E2, and SHBG levels. None had postoperative improvements in their semen analyses and no spontaneous pregnancies occurred in their partners. Three pregnancies occurred with IUI.
The men with excessive responses to GnRH had abnormal free sex steroid levels. The majority had improvements in semen analyses after varicocele repair and pregnancies occurred in their partners. The men with normal gonadotropin responses to GnRH had normal free sex steroid levels. Varicocele ligation had no effect on their semen parameters or fertility potential.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)58457-X</identifier><identifier>PMID: 8690120</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Estrogens - blood ; Follicle Stimulating Hormone - blood ; free T ; Gonadotropin-Releasing Hormone - pharmacology ; Gynecology. Andrology. Obstetrics ; Humans ; improvement with surgery ; Infertility, Male - blood ; Infertility, Male - etiology ; Luteinizing Hormone - blood ; Male ; Male genital diseases ; Medical sciences ; Non tumoral diseases ; Oligospermia - blood ; Oligospermia - complications ; Oligospermia - pathology ; response to GnRH ; Retrospective Studies ; Semen - cytology ; Semen - drug effects ; Sex Hormone-Binding Globulin - analysis ; Sperm Count ; Testosterone - blood ; Thyrotropin-Releasing Hormone - pharmacology ; Varicocele ; Varicocele - blood ; Varicocele - complications ; Varicocele - pathology</subject><ispartof>Fertility and sterility, 1996-08, Vol.66 (2), p.299-304</ispartof><rights>1996 American Society for Reproductive Medicine</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-2ebe2d355c63c45592cbc38ec79d9b229a9011e99b918e886206a36342104e9a3</citedby><cites>FETCH-LOGICAL-c389t-2ebe2d355c63c45592cbc38ec79d9b229a9011e99b918e886206a36342104e9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)58457-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3183151$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8690120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudson, Robert W.</creatorcontrib><title>Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles.
Retrospective study.
Sixty-four infertile patients with varicoceles.
A university-based tertiary care referral center.
Assessment of seminal cellular characteristics, gonadotropin responses to GnRH, total and free T, and E2 and SHBG levels before and after varicocele ligation.
Thirty-eight men had excessive preoperative gonadotropin responses to GnRH. These men had lower than normal levels of free T and higher than normal levels of free E2 and SHBG. Thirty men had improvements in seminal parameters, and sex steroid and SHBG values after surgery. Seven spontaneous pregnancies and three pregnancies through IUI occurred in their partners postoperatively. Twenty-six men had normal preoperative responses to GnRH and normal free T, E2, and SHBG levels. None had postoperative improvements in their semen analyses and no spontaneous pregnancies occurred in their partners. Three pregnancies occurred with IUI.
The men with excessive responses to GnRH had abnormal free sex steroid levels. The majority had improvements in semen analyses after varicocele repair and pregnancies occurred in their partners. The men with normal gonadotropin responses to GnRH had normal free sex steroid levels. Varicocele ligation had no effect on their semen parameters or fertility potential.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Estrogens - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>free T</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>improvement with surgery</subject><subject>Infertility, Male - blood</subject><subject>Infertility, Male - etiology</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Oligospermia - blood</subject><subject>Oligospermia - complications</subject><subject>Oligospermia - pathology</subject><subject>response to GnRH</subject><subject>Retrospective Studies</subject><subject>Semen - cytology</subject><subject>Semen - drug effects</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Sperm Count</subject><subject>Testosterone - blood</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><subject>Varicocele</subject><subject>Varicocele - blood</subject><subject>Varicocele - complications</subject><subject>Varicocele - pathology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq0KRAPtT0DyAaFyWOqP2GufUBWVthISB1qJm-v1ToKR1w72JoX-ekwS5crJM3qf8YwehE4puaSEyq93hFDREKbYFyovhJqKtrn_gCZUCNkIKfgBmuyRj-i4lEdCiKQtO0JHSmpCGZmgv9cZABd4xmWEnHyPbew3_UPKQ4rQdD72Pi7wIqRuFXzEAdYQCq5VCn6R_qdUlpAH7_AAEf_z4wNe2-xdchCgfEKHcxsKfN69J-jP9fffs5_Nze2PX7NvN43jSo8Ngw5Yz4VwkrupEJq5ribgWt3rjjFt68EUtO40VaCUZERaLvmUUTIFbfkJOt_-u8zpaQVlNIMv9YJgI6RVMa2iiutWV1BsQZdTKRnmZpn9YPOLocS8mTUbs-ZNm6ndxqy5r3OnuwWrboB-P7VTWfOzXW6Ls2GebXS-7DFe11NBK3a1xapDWHvIpjgP0UHvM7jR9Mm_c8grHTSVww</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Hudson, Robert W.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles</title><author>Hudson, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-2ebe2d355c63c45592cbc38ec79d9b229a9011e99b918e886206a36342104e9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Estrogens - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>free T</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>improvement with surgery</topic><topic>Infertility, Male - blood</topic><topic>Infertility, Male - etiology</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Oligospermia - blood</topic><topic>Oligospermia - complications</topic><topic>Oligospermia - pathology</topic><topic>response to GnRH</topic><topic>Retrospective Studies</topic><topic>Semen - cytology</topic><topic>Semen - drug effects</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Sperm Count</topic><topic>Testosterone - blood</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><topic>Varicocele</topic><topic>Varicocele - blood</topic><topic>Varicocele - complications</topic><topic>Varicocele - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, Robert W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>66</volume><issue>2</issue><spage>299</spage><epage>304</epage><pages>299-304</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles.
Retrospective study.
Sixty-four infertile patients with varicoceles.
A university-based tertiary care referral center.
Assessment of seminal cellular characteristics, gonadotropin responses to GnRH, total and free T, and E2 and SHBG levels before and after varicocele ligation.
Thirty-eight men had excessive preoperative gonadotropin responses to GnRH. These men had lower than normal levels of free T and higher than normal levels of free E2 and SHBG. Thirty men had improvements in seminal parameters, and sex steroid and SHBG values after surgery. Seven spontaneous pregnancies and three pregnancies through IUI occurred in their partners postoperatively. Twenty-six men had normal preoperative responses to GnRH and normal free T, E2, and SHBG levels. None had postoperative improvements in their semen analyses and no spontaneous pregnancies occurred in their partners. Three pregnancies occurred with IUI.
The men with excessive responses to GnRH had abnormal free sex steroid levels. The majority had improvements in semen analyses after varicocele repair and pregnancies occurred in their partners. The men with normal gonadotropin responses to GnRH had normal free sex steroid levels. Varicocele ligation had no effect on their semen parameters or fertility potential.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8690120</pmid><doi>10.1016/S0015-0282(16)58457-X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Fertility and sterility, 1996-08, Vol.66 (2), p.299-304 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78183979 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Estrogens - blood Follicle Stimulating Hormone - blood free T Gonadotropin-Releasing Hormone - pharmacology Gynecology. Andrology. Obstetrics Humans improvement with surgery Infertility, Male - blood Infertility, Male - etiology Luteinizing Hormone - blood Male Male genital diseases Medical sciences Non tumoral diseases Oligospermia - blood Oligospermia - complications Oligospermia - pathology response to GnRH Retrospective Studies Semen - cytology Semen - drug effects Sex Hormone-Binding Globulin - analysis Sperm Count Testosterone - blood Thyrotropin-Releasing Hormone - pharmacology Varicocele Varicocele - blood Varicocele - complications Varicocele - pathology |
| title | Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles |
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