Enhancement of crystalloid cardioplegic protection against global normothermic ischemia by superoxide dismutase plus catalase but not diltiazem in the isolated, working rat heart

Oxygen-derived free radicals and intracellular calcium overload have been implicated as mediators of myocardial ischemia/reperfusion injury. We hypothesized that free radical scavengers or calcium channel blockers could enhance the protection afforded the isolated, working rat heart by crystalloid c...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 1988-05, Vol.95 (5), p.799-813
Hauptverfasser:	Greenfield, DT, Greenfield, LJ, Hess, ML
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Bicarbonates Biological and medical sciences Calcium Chloride Cardioplegic Solutions Catalase - therapeutic use Coronary Circulation Diltiazem - therapeutic use Free Radicals Heart Arrest, Induced Magnesium Male Medical sciences Myocardial Contraction Myocardium - metabolism Perfusion Potassium Chloride Rats Rats, Inbred Strains Sodium Chloride Superoxide Dismutase - therapeutic use Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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