Physical Mapping of the Retinoblastoma Interacting Zinc Finger Gene RIZ to D1S228 on Chromosome 1p36

The retinoblastoma interacting zinc finger gene RIZ is a member of the recently discovered PR domain family that includes the MDS1–EVI1 breakpoint gene involved in human leukemia. To help understand the role of RIZ in human diseases, we have determined the cytogenetic and physical localizations of t...

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Veröffentlicht in:Genomics 1996-05, Vol.34 (1), p.119-121
Hauptverfasser: Buyse, Inge M., Takahashi, Ei-ichi, Huang, Shi
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creator Buyse, Inge M.
Takahashi, Ei-ichi
Huang, Shi
description The retinoblastoma interacting zinc finger gene RIZ is a member of the recently discovered PR domain family that includes the MDS1–EVI1 breakpoint gene involved in human leukemia. To help understand the role of RIZ in human diseases, we have determined the cytogenetic and physical localizations of the RIZ gene. Using fluorescencein situhybridization, we determined that RIZ maps to 1p36. On the physical map, RIZ is adjacent to the polymorphic marker D1S228. We suggest that the RIZ gene may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, and lymphoid tumors.
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Biological and molecular evolution</topic><topic>HEREDITARY DISEASES</topic><topic>Histone-Lysine N-Methyltransferase</topic><topic>Human</topic><topic>HUMAN CHROMOSOME 1</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>IN-SITU HYBRIDIZATION</topic><topic>MAN</topic><topic>Molecular Sequence Data</topic><topic>NEOPLASMS</topic><topic>Nuclear Proteins - genetics</topic><topic>POLYMERASE CHAIN REACTION</topic><topic>PROTEINS</topic><topic>STRUCTURE-ACTIVITY RELATIONSHIPS</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buyse, Inge M.</creatorcontrib><creatorcontrib>Takahashi, Ei-ichi</creatorcontrib><creatorcontrib>Huang, Shi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buyse, Inge M.</au><au>Takahashi, Ei-ichi</au><au>Huang, Shi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Mapping of the Retinoblastoma Interacting Zinc Finger Gene RIZ to D1S228 on Chromosome 1p36</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1996-05-15</date><risdate>1996</risdate><volume>34</volume><issue>1</issue><spage>119</spage><epage>121</epage><pages>119-121</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The retinoblastoma interacting zinc finger gene RIZ is a member of the recently discovered PR domain family that includes the MDS1–EVI1 breakpoint gene involved in human leukemia. To help understand the role of RIZ in human diseases, we have determined the cytogenetic and physical localizations of the RIZ gene. Using fluorescencein situhybridization, we determined that RIZ maps to 1p36. On the physical map, RIZ is adjacent to the polymorphic marker D1S228. We suggest that the RIZ gene may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, and lymphoid tumors.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8661032</pmid><doi>10.1006/geno.1996.0249</doi><tpages>3</tpages></addata></record>
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subjects AMINO ACIDS
Base Sequence
Biological and medical sciences
BIOLOGICAL MARKERS
BIOLOGY AND MEDICINE, BASIC STUDIES
CHROMOSOMAL ABERRATIONS
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 1
Classical genetics, quantitative genetics, hybrids
DNA SEQUENCING
DNA-Binding Proteins
DNA-CLONING
FLUORESCENCE
Fundamental and applied biological sciences. Psychology
GENE MUTATIONS
GENES
GENETIC MAPPING
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
HEREDITARY DISEASES
Histone-Lysine N-Methyltransferase
Human
HUMAN CHROMOSOME 1
Humans
In Situ Hybridization, Fluorescence
IN-SITU HYBRIDIZATION
MAN
Molecular Sequence Data
NEOPLASMS
Nuclear Proteins - genetics
POLYMERASE CHAIN REACTION
PROTEINS
STRUCTURE-ACTIVITY RELATIONSHIPS
Transcription Factors
title Physical Mapping of the Retinoblastoma Interacting Zinc Finger Gene RIZ to D1S228 on Chromosome 1p36
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