The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family
The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between th...
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| Veröffentlicht in: | FEBS letters 1988-04, Vol.231 (1), p.164-171 |
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| creator | Wathelet, Marc G. Clauss, Isabelle M. Content, Jean Huez, Georges A. |
| description | The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene. |
| doi_str_mv | 10.1016/0014-5793(88)80724-5 |
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Psychology ; Fundamental immunology ; Gene Expression Regulation ; Genes ; Humans ; IFN, interferon ; Immunobiology ; Interferon Type I - physiology ; Lymphokines, interleukins ( function, expression) ; Molecular Sequence Data ; Molecular Weight ; Needleman-Wunsch-Sellers algorithm ; poly(rI)·poly(rC), polyriboinosinic-polyribocytidylic acid ; Poly(rI)·poly(rC)-inducible gene ; Regulatory factors and their cellular receptors ; Sequence comparison ; Virus-inducible gene</subject><ispartof>FEBS letters, 1988-04, Vol.231 (1), p.164-171</ispartof><rights>1988</rights><rights>FEBS Letters 231 (1988) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4805-4f07015e326ca5613030453460de9ba78622312aeeef992d471066e220decdee3</citedby><cites>FETCH-LOGICAL-c4805-4f07015e326ca5613030453460de9ba78622312aeeef992d471066e220decdee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579388807245$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7156291$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3360121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wathelet, Marc G.</creatorcontrib><creatorcontrib>Clauss, Isabelle M.</creatorcontrib><creatorcontrib>Content, Jean</creatorcontrib><creatorcontrib>Huez, Georges A.</creatorcontrib><title>The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene.</description><subject>Amino Acid Sequence</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 10</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Humans</subject><subject>IFN, interferon</subject><subject>Immunobiology</subject><subject>Interferon Type I - physiology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Needleman-Wunsch-Sellers algorithm</subject><subject>poly(rI)·poly(rC), polyriboinosinic-polyribocytidylic acid</subject><subject>Poly(rI)·poly(rC)-inducible gene</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Sequence comparison</subject><subject>Virus-inducible gene</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9v1DAQxS1EVZbCNwDJB4TgEPB_O5dKUHXpqpW4FHG0vM6kNUqcYiet9tsTb1Z7BE625_3meeYh9IaST5RQ9ZkQKiqpa_7BmI-GaDa_nqEVNZpXXCjzHK2OyAv0MudfZH4bWp-iU84VoYyu0M_be8Cb9aaS6hq72Cx3cY1DHCG1kIZYhdhMPmw7wPdT7yK-gwgZb6Eb4h0eBzzOFtn1sBdw6_rQ7V6hk9Z1GV4fzjP0Y315e3FV3Xz_trn4clN5YYisREs0oRI4U95JRTnhRMh5etJAvXXaKMY4ZQ4A2rpmjdCUKAWMzbpvAPgZer_4PqTh9wR5tH3IHrrORRimbLUpGwv9T5BKZoykBRQL6NOQc4LWPqTQu7SzlNgSvC2p2pKqNcbug7dybnt78J-2PTTHpkPSs_7uoLvsXdcmF33IR0xTqVhdsPWCPYUOdv_1tV1ffmVFKHVj9tUyz_liBHP6jwGSzT5A9NCEBH60zRD-vtAfhR6uWw</recordid><startdate>19880411</startdate><enddate>19880411</enddate><creator>Wathelet, Marc G.</creator><creator>Clauss, Isabelle M.</creator><creator>Content, Jean</creator><creator>Huez, Georges A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19880411</creationdate><title>The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family</title><author>Wathelet, Marc G. ; Clauss, Isabelle M. ; Content, Jean ; Huez, Georges A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4805-4f07015e326ca5613030453460de9ba78622312aeeef992d471066e220decdee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 10</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Humans</topic><topic>IFN, interferon</topic><topic>Immunobiology</topic><topic>Interferon Type I - physiology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Needleman-Wunsch-Sellers algorithm</topic><topic>poly(rI)·poly(rC), polyriboinosinic-polyribocytidylic acid</topic><topic>Poly(rI)·poly(rC)-inducible gene</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Sequence comparison</topic><topic>Virus-inducible gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wathelet, Marc G.</creatorcontrib><creatorcontrib>Clauss, Isabelle M.</creatorcontrib><creatorcontrib>Content, Jean</creatorcontrib><creatorcontrib>Huez, Georges A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wathelet, Marc G.</au><au>Clauss, Isabelle M.</au><au>Content, Jean</au><au>Huez, Georges A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1988-04-11</date><risdate>1988</risdate><volume>231</volume><issue>1</issue><spage>164</spage><epage>171</epage><pages>164-171</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3360121</pmid><doi>10.1016/0014-5793(88)80724-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1988-04, Vol.231 (1), p.164-171 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_78181947 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 13 Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Genes Humans IFN, interferon Immunobiology Interferon Type I - physiology Lymphokines, interleukins ( function, expression) Molecular Sequence Data Molecular Weight Needleman-Wunsch-Sellers algorithm poly(rI)·poly(rC), polyriboinosinic-polyribocytidylic acid Poly(rI)·poly(rC)-inducible gene Regulatory factors and their cellular receptors Sequence comparison Virus-inducible gene |
| title | The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family |
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