Morphological and hemostatic changes in rats with abdominal arterial prosthesis
We evaluated the changes over time in hemostatic factors during ongoing arterial thrombosis in rats, as induced by a loop-shaped aortic prosthesis. Moreover, we investigated this condition by inspecting in parallel cocal thrombus growth, systemic vascular prostacyclin and t-PA production. One minute...
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| Veröffentlicht in: | Thrombosis research 1996-04, Vol.82 (1), p.69-77 |
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| creator | Chabielska, Ewa Kolpakov, Valeri D'Adamo, Maria Cristina De Curtis, Amalia Buczko, Wlodzimierz Iacoviello, Licia Donati, Maria Benedetta |
| description | We evaluated the changes over time in hemostatic factors during ongoing arterial thrombosis in rats, as induced by a loop-shaped aortic prosthesis. Moreover, we investigated this condition by inspecting in parallel cocal thrombus growth, systemic vascular prostacyclin and t-PA production. One minute after loop insertion, activated platelets spread on the internal surface of the prosthesis and 24 hrs later numerous platelet aggregates supported by a fibrin network could be observed. However, no evidence for platelet activation could be concomitantly found in peripheral blood. A sustained increase in PGI
2 formation was detected together with a progressive increase in plasma fibrinolytic activity during thrombus growth. The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals. In conclusion, the dynamic phases of thrombus formation, in an aortic prosthesis, produce changes in vascular function and in hemostatic factors at the level of systemic blood. |
| doi_str_mv | 10.1016/0049-3848(96)00052-7 |
| format | Article |
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2 formation was detected together with a progressive increase in plasma fibrinolytic activity during thrombus growth. The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals. In conclusion, the dynamic phases of thrombus formation, in an aortic prosthesis, produce changes in vascular function and in hemostatic factors at the level of systemic blood.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(96)00052-7</identifier><identifier>PMID: 8731511</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>6-Ketoprostaglandin F1 alpha - blood ; Animals ; Aorta ; arterial thrombosis ; Biological and medical sciences ; Blood Coagulation Factors - metabolism ; Blood Vessel Prosthesis ; Fibrin - metabolism ; Fibrinolysis ; Hemostasis ; Leukocyte Count ; Male ; Medical sciences ; Platelet Aggregation ; Platelet Count ; Prostheses and Implants ; rat ; Rats ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thrombosis - pathology ; Time Factors ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Thrombosis research, 1996-04, Vol.82 (1), p.69-77</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a7398b544f0a804c7d9ac4a7c06117c343a4629af155b6b48f8fd26b71cede903</citedby><cites>FETCH-LOGICAL-c386t-a7398b544f0a804c7d9ac4a7c06117c343a4629af155b6b48f8fd26b71cede903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(96)00052-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3085545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8731511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chabielska, Ewa</creatorcontrib><creatorcontrib>Kolpakov, Valeri</creatorcontrib><creatorcontrib>D'Adamo, Maria Cristina</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Buczko, Wlodzimierz</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><title>Morphological and hemostatic changes in rats with abdominal arterial prosthesis</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>We evaluated the changes over time in hemostatic factors during ongoing arterial thrombosis in rats, as induced by a loop-shaped aortic prosthesis. Moreover, we investigated this condition by inspecting in parallel cocal thrombus growth, systemic vascular prostacyclin and t-PA production. One minute after loop insertion, activated platelets spread on the internal surface of the prosthesis and 24 hrs later numerous platelet aggregates supported by a fibrin network could be observed. However, no evidence for platelet activation could be concomitantly found in peripheral blood. A sustained increase in PGI
2 formation was detected together with a progressive increase in plasma fibrinolytic activity during thrombus growth. The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals. In conclusion, the dynamic phases of thrombus formation, in an aortic prosthesis, produce changes in vascular function and in hemostatic factors at the level of systemic blood.</description><subject>6-Ketoprostaglandin F1 alpha - blood</subject><subject>Animals</subject><subject>Aorta</subject><subject>arterial thrombosis</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Factors - metabolism</subject><subject>Blood Vessel Prosthesis</subject><subject>Fibrin - metabolism</subject><subject>Fibrinolysis</subject><subject>Hemostasis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Platelet Aggregation</subject><subject>Platelet Count</subject><subject>Prostheses and Implants</subject><subject>rat</subject><subject>Rats</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thrombosis - pathology</subject><subject>Time Factors</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAyEQhonR1Fr9B5rswRg9rMICC1xMTONXUtOLnsksy3Yx-1Fhq_Hfy6ZNj56AzPPODA9C5wTfEkzyO4yZSqlk8lrlNxhjnqXiAE2JFCrNmMgO0XSPHKOTED4xJoIoPkETKSjhhEzR8q3367pv-pUz0CTQlUlt2z4MMDiTmBq6lQ2J6xIPQ0h-3FAnUJR967qR9oP1Ll7WPiZqG1w4RUcVNMGe7c4Z-nh6fJ-_pIvl8-v8YZEaKvMhBUGVLDhjFQaJmRGlAsNAGJwTIgxlFFieKagI50VeMFnJqszyQhBjS6swnaGrbd84-mtjw6BbF4xtGuhsvwlaSCIUxyPItqCJOwZvK732rgX_qwnWo0c9StKjJK3GR_SoRYxd7PpvitaW-9BOXKxf7uoQorjKQ2dc2GMUS84Zj9j9FrPRxbezXgfjbBc_4bw1gy579_8ef3dBjvI</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Chabielska, Ewa</creator><creator>Kolpakov, Valeri</creator><creator>D'Adamo, Maria Cristina</creator><creator>De Curtis, Amalia</creator><creator>Buczko, Wlodzimierz</creator><creator>Iacoviello, Licia</creator><creator>Donati, Maria Benedetta</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Morphological and hemostatic changes in rats with abdominal arterial prosthesis</title><author>Chabielska, Ewa ; Kolpakov, Valeri ; D'Adamo, Maria Cristina ; De Curtis, Amalia ; Buczko, Wlodzimierz ; Iacoviello, Licia ; Donati, Maria Benedetta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a7398b544f0a804c7d9ac4a7c06117c343a4629af155b6b48f8fd26b71cede903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>6-Ketoprostaglandin F1 alpha - blood</topic><topic>Animals</topic><topic>Aorta</topic><topic>arterial thrombosis</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Factors - metabolism</topic><topic>Blood Vessel Prosthesis</topic><topic>Fibrin - metabolism</topic><topic>Fibrinolysis</topic><topic>Hemostasis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Platelet Aggregation</topic><topic>Platelet Count</topic><topic>Prostheses and Implants</topic><topic>rat</topic><topic>Rats</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thrombosis - pathology</topic><topic>Time Factors</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chabielska, Ewa</creatorcontrib><creatorcontrib>Kolpakov, Valeri</creatorcontrib><creatorcontrib>D'Adamo, Maria Cristina</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Buczko, Wlodzimierz</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chabielska, Ewa</au><au>Kolpakov, Valeri</au><au>D'Adamo, Maria Cristina</au><au>De Curtis, Amalia</au><au>Buczko, Wlodzimierz</au><au>Iacoviello, Licia</au><au>Donati, Maria Benedetta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological and hemostatic changes in rats with abdominal arterial prosthesis</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>82</volume><issue>1</issue><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>We evaluated the changes over time in hemostatic factors during ongoing arterial thrombosis in rats, as induced by a loop-shaped aortic prosthesis. Moreover, we investigated this condition by inspecting in parallel cocal thrombus growth, systemic vascular prostacyclin and t-PA production. One minute after loop insertion, activated platelets spread on the internal surface of the prosthesis and 24 hrs later numerous platelet aggregates supported by a fibrin network could be observed. However, no evidence for platelet activation could be concomitantly found in peripheral blood. A sustained increase in PGI
2 formation was detected together with a progressive increase in plasma fibrinolytic activity during thrombus growth. The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals. In conclusion, the dynamic phases of thrombus formation, in an aortic prosthesis, produce changes in vascular function and in hemostatic factors at the level of systemic blood.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>8731511</pmid><doi>10.1016/0049-3848(96)00052-7</doi><tpages>9</tpages></addata></record> |
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| subjects | 6-Ketoprostaglandin F1 alpha - blood Animals Aorta arterial thrombosis Biological and medical sciences Blood Coagulation Factors - metabolism Blood Vessel Prosthesis Fibrin - metabolism Fibrinolysis Hemostasis Leukocyte Count Male Medical sciences Platelet Aggregation Platelet Count Prostheses and Implants rat Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis - pathology Time Factors Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Morphological and hemostatic changes in rats with abdominal arterial prosthesis |
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