Intermediate filament aggregates in mitoses of primary cutaneous neuroendocrine (Merkel cell) carcinoma
Primary cutaneous neuroendocrine carcinomas express different kinds of intermediate filaments and frequently in a ‘paranuclear globular’ pattern. We have observed the same pattern not only in interphase but also in mitotic cells, which are very frequent in these tumours. We report a quantitative and...
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| Veröffentlicht in: | Histopathology 1996-04, Vol.28 (4), p.349-355 |
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| creator | ALVAREZ-GAGO, T. M.BULLÓN, M. RIVERA, F. VELASCO, A. MAYO, A. |
| description | Primary cutaneous neuroendocrine carcinomas express different kinds of intermediate filaments and frequently in a ‘paranuclear globular’ pattern. We have observed the same pattern not only in interphase but also in mitotic cells, which are very frequent in these tumours. We report a quantitative and morphological study of eight primary cutaneous neuroendocrine carcinomas stained with different antibodies against cytokeratins (CAM 5.2 and anti‐cytokeratin 20), neurofilaments (70 kDa and 200 kDa) and peripherin. We have found a predominance of CAM 5.2 expression in interphase cells and of neurofilament proteins in mitotic cells; 87.02% of the interphase cells were positive with CAM 5.2 whereas only 6.08% were positive for neurofilaments (P |
| doi_str_mv | 10.1046/j.1365-2559.1996.d01-434.x |
| format | Article |
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We have observed the same pattern not only in interphase but also in mitotic cells, which are very frequent in these tumours. We report a quantitative and morphological study of eight primary cutaneous neuroendocrine carcinomas stained with different antibodies against cytokeratins (CAM 5.2 and anti‐cytokeratin 20), neurofilaments (70 kDa and 200 kDa) and peripherin. We have found a predominance of CAM 5.2 expression in interphase cells and of neurofilament proteins in mitotic cells; 87.02% of the interphase cells were positive with CAM 5.2 whereas only 6.08% were positive for neurofilaments (P<0.01); 35.41% of the mitotic cells were positive with CAM 5.2, whereas 50% were positive for neurofilaments (P<0.01). A correlation between a globular pattern of intermediate filament proteins and prognosis has not been found. We describe for the first time the division of neoplastic cells with a globular pattern; the presence of intermediate filament proteins with a globular pattern in all mitotic stages; and the uneven distribution of this formation between the two daughter cells.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.1996.d01-434.x</identifier><identifier>PMID: 8732344</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Merkel Cell - chemistry ; Carcinoma, Merkel Cell - pathology ; Dermatology ; Humans ; Immunohistochemistry ; intermediate filaments ; Intermediate Filaments - chemistry ; Intermediate Filaments - pathology ; keratin ; Medical sciences ; Middle Aged ; Mitosis ; neuroendocrine (Merkel cell) carcinoma ; neurofilaments ; peripherin ; Skin Neoplasms - chemistry ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Histopathology, 1996-04, Vol.28 (4), p.349-355</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4365-358b4a5152e2d0805d03c678f8d15d394620e15b21676a76d0efb61b7e8776553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2559.1996.d01-434.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.1996.d01-434.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3063012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8732344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALVAREZ-GAGO, T.</creatorcontrib><creatorcontrib>M.BULLÓN, M.</creatorcontrib><creatorcontrib>RIVERA, F.</creatorcontrib><creatorcontrib>VELASCO, A.</creatorcontrib><creatorcontrib>MAYO, A.</creatorcontrib><title>Intermediate filament aggregates in mitoses of primary cutaneous neuroendocrine (Merkel cell) carcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Primary cutaneous neuroendocrine carcinomas express different kinds of intermediate filaments and frequently in a ‘paranuclear globular’ pattern. We have observed the same pattern not only in interphase but also in mitotic cells, which are very frequent in these tumours. We report a quantitative and morphological study of eight primary cutaneous neuroendocrine carcinomas stained with different antibodies against cytokeratins (CAM 5.2 and anti‐cytokeratin 20), neurofilaments (70 kDa and 200 kDa) and peripherin. We have found a predominance of CAM 5.2 expression in interphase cells and of neurofilament proteins in mitotic cells; 87.02% of the interphase cells were positive with CAM 5.2 whereas only 6.08% were positive for neurofilaments (P<0.01); 35.41% of the mitotic cells were positive with CAM 5.2, whereas 50% were positive for neurofilaments (P<0.01). A correlation between a globular pattern of intermediate filament proteins and prognosis has not been found. We describe for the first time the division of neoplastic cells with a globular pattern; the presence of intermediate filament proteins with a globular pattern in all mitotic stages; and the uneven distribution of this formation between the two daughter cells.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Merkel Cell - chemistry</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>intermediate filaments</subject><subject>Intermediate Filaments - chemistry</subject><subject>Intermediate Filaments - pathology</subject><subject>keratin</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitosis</subject><subject>neuroendocrine (Merkel cell) carcinoma</subject><subject>neurofilaments</subject><subject>peripherin</subject><subject>Skin Neoplasms - chemistry</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtv1DAQhS1EVbaFn4BkIYTgIcGX2E54QEJVu126LRLXR8txJitvcyl2Irb_vo4S7TtPY_mcmTnzIfSGkpSSTH7cp5RLkTAhipQWhUwrQpOMZ-nhGVodpedoRTgpEkKleoHOQtgTQhVn7BSd5rHyLFuh3aYbwLdQOTMArl1jWugGbHY7D7v4FbDrcOuGPsRnX-MH71rjH7EdB9NBPwbcweh76KreetcBfn8L_h4abKFpPmBrvHVd35qX6KQ2TYBXSz1Hv64uf15cJ9tv683Fl21isyk3F3mZGUEFA1aRnIiKcCtVXucVFRUvMskIUFGyeJM0SlYE6lLSUkGulBSCn6N389wH3_8dIQy6dWHKMqfVKqeqYIxF46fZaH0fgodaL6dpSvREWe_1hFJPKPVEWUfKOlLWh9j8etkylpHdsXXBGvW3i26CNU3tTWddONo4kZzQKcPn2fbPNfD4HwH09eYHp9O1yTzAhQEOxwHG32upuBL6z91a8-83N-urr1v9mz8B-IaovA</recordid><startdate>199604</startdate><enddate>199604</enddate><creator>ALVAREZ-GAGO, T.</creator><creator>M.BULLÓN, M.</creator><creator>RIVERA, F.</creator><creator>VELASCO, A.</creator><creator>MAYO, A.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199604</creationdate><title>Intermediate filament aggregates in mitoses of primary cutaneous neuroendocrine (Merkel cell) carcinoma</title><author>ALVAREZ-GAGO, T. ; M.BULLÓN, M. ; RIVERA, F. ; VELASCO, A. ; MAYO, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-358b4a5152e2d0805d03c678f8d15d394620e15b21676a76d0efb61b7e8776553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Merkel Cell - chemistry</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>intermediate filaments</topic><topic>Intermediate Filaments - chemistry</topic><topic>Intermediate Filaments - pathology</topic><topic>keratin</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitosis</topic><topic>neuroendocrine (Merkel cell) carcinoma</topic><topic>neurofilaments</topic><topic>peripherin</topic><topic>Skin Neoplasms - chemistry</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALVAREZ-GAGO, T.</creatorcontrib><creatorcontrib>M.BULLÓN, M.</creatorcontrib><creatorcontrib>RIVERA, F.</creatorcontrib><creatorcontrib>VELASCO, A.</creatorcontrib><creatorcontrib>MAYO, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALVAREZ-GAGO, T.</au><au>M.BULLÓN, M.</au><au>RIVERA, F.</au><au>VELASCO, A.</au><au>MAYO, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermediate filament aggregates in mitoses of primary cutaneous neuroendocrine (Merkel cell) carcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>1996-04</date><risdate>1996</risdate><volume>28</volume><issue>4</issue><spage>349</spage><epage>355</epage><pages>349-355</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Primary cutaneous neuroendocrine carcinomas express different kinds of intermediate filaments and frequently in a ‘paranuclear globular’ pattern. We have observed the same pattern not only in interphase but also in mitotic cells, which are very frequent in these tumours. We report a quantitative and morphological study of eight primary cutaneous neuroendocrine carcinomas stained with different antibodies against cytokeratins (CAM 5.2 and anti‐cytokeratin 20), neurofilaments (70 kDa and 200 kDa) and peripherin. We have found a predominance of CAM 5.2 expression in interphase cells and of neurofilament proteins in mitotic cells; 87.02% of the interphase cells were positive with CAM 5.2 whereas only 6.08% were positive for neurofilaments (P<0.01); 35.41% of the mitotic cells were positive with CAM 5.2, whereas 50% were positive for neurofilaments (P<0.01). A correlation between a globular pattern of intermediate filament proteins and prognosis has not been found. We describe for the first time the division of neoplastic cells with a globular pattern; the presence of intermediate filament proteins with a globular pattern in all mitotic stages; and the uneven distribution of this formation between the two daughter cells.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>8732344</pmid><doi>10.1046/j.1365-2559.1996.d01-434.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma, Merkel Cell - chemistry Carcinoma, Merkel Cell - pathology Dermatology Humans Immunohistochemistry intermediate filaments Intermediate Filaments - chemistry Intermediate Filaments - pathology keratin Medical sciences Middle Aged Mitosis neuroendocrine (Merkel cell) carcinoma neurofilaments peripherin Skin Neoplasms - chemistry Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Intermediate filament aggregates in mitoses of primary cutaneous neuroendocrine (Merkel cell) carcinoma |
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