HA1 domain of influenza A (H3N2) viruses in Finland in 1989-1995 : evolution, egg-adaptation and relationship to vaccine strains

The HA1 gene sequences of 22 MDCK cell-derived influenza A (H3N2) strains, ten of their egg-derived counterparts and three vaccine strains were determined. Antigenic and sequence differences between the epidemic and vaccine strains were recorded, most striking in 1992/93; a minority of the amino aci...

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Veröffentlicht in:	Archives of virology 1996-01, Vol.141 (6), p.1033-1046
Hauptverfasser:	PYHÄLÄ, R, IKONEN, N, HAANPÄÄ, M, KINNUNEN, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Amino Acid Sequence Animals Antigens, Viral - genetics Antigens, Viral - immunology Base Sequence Biological and medical sciences Cell Line Chick Embryo Disease Outbreaks DNA, Viral Dogs Finland - epidemiology Fundamental and applied biological sciences. Psychology Genetics Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral - genetics Hemagglutinins, Viral - immunology Humans influenza A virus Influenza A virus - genetics Influenza A virus - immunology Influenza A Virus, H3N2 Subtype Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - virology Microbiology Molecular Sequence Data Ovum - virology Phylogeny Retrospective Studies Sequence Homology, Amino Acid Species Specificity Virology
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