Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats
Alterations in local cerebral glucose utilization (LCGU) in conscious rats during stimulation of the striatum and the globus pallidus were investigated using the [ 14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the...
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| Veröffentlicht in: | Brain research 1988-02, Vol.442 (1), p.43-52 |
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| creator | Aiko, Yasutaka Hosokawa, Shinichi Shima, Fumio Kato, Motohiro Kitamura, Katsutoshi |
| description | Alterations in local cerebral glucose utilization (LCGU) in conscious rats during stimulation of the striatum and the globus pallidus were investigated using the [
14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the striatum led only to contraversive head turning. Unilateral stimulation of the striatum increased LCGU bilaterally in the globus pallidus and substantia nigra pars compacta, but only ipsilaterally in the entopeduncular nucleus, substantia nigra pars reticulata and subthalamic nucleus. Similar stimulation of the globus pallidus increased LCGU in the globus pallidus, substantia nigra pars reticulata and compacta, entopeduncular nucleus, subthalamic nucleus, lateral habenular nucleus, parafascicular nucleus of the thalamus, deep layers of the superior colliculus and pedunculopontine nucleus, exclusively on the ipsilateral side. These results indicate that the electrical stimulation induces LCGU changes in the respective structures having both monosynaptic and transsynaptic neuronal inputs. Some changes may also be mediated by antidromic activation. They also suggest that activation of a synaptic process whether excitatory or inhibitory results in increases in LCGU. The bilateral modulatory effects of striatal stimulation may cancel out the circling behavior seen during pallidal stimulation, and cause only head turning. |
| doi_str_mv | 10.1016/0006-8993(88)91430-8 |
| format | Article |
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14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the striatum led only to contraversive head turning. Unilateral stimulation of the striatum increased LCGU bilaterally in the globus pallidus and substantia nigra pars compacta, but only ipsilaterally in the entopeduncular nucleus, substantia nigra pars reticulata and subthalamic nucleus. Similar stimulation of the globus pallidus increased LCGU in the globus pallidus, substantia nigra pars reticulata and compacta, entopeduncular nucleus, subthalamic nucleus, lateral habenular nucleus, parafascicular nucleus of the thalamus, deep layers of the superior colliculus and pedunculopontine nucleus, exclusively on the ipsilateral side. These results indicate that the electrical stimulation induces LCGU changes in the respective structures having both monosynaptic and transsynaptic neuronal inputs. Some changes may also be mediated by antidromic activation. They also suggest that activation of a synaptic process whether excitatory or inhibitory results in increases in LCGU. The bilateral modulatory effects of striatal stimulation may cancel out the circling behavior seen during pallidal stimulation, and cause only head turning.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(88)91430-8</identifier><identifier>PMID: 3359255</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>[ 14C]Deoxyglucose method ; Animals ; Autoradiography ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Circling behavior ; Corpus Striatum - metabolism ; Corpus Striatum - physiology ; Deoxy Sugars - metabolism ; Deoxyglucose - metabolism ; Electric Stimulation ; Electrical stimulation ; Fundamental and applied biological sciences. Psychology ; Globus pallidus ; Globus Pallidus - metabolism ; Globus Pallidus - physiology ; Local cerebral glucose utilization ; Male ; Rats ; Rats, Inbred Strains ; Stereotyped Behavior - physiology ; Striatum ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1988-02, Vol.442 (1), p.43-52</ispartof><rights>1988</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b1105123d00f8e9aea9d3d8cc7ef47f1a10dda655d4e673dce45e47be7eb5bc93</citedby><cites>FETCH-LOGICAL-c452t-b1105123d00f8e9aea9d3d8cc7ef47f1a10dda655d4e673dce45e47be7eb5bc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899388914308$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7623554$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3359255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aiko, Yasutaka</creatorcontrib><creatorcontrib>Hosokawa, Shinichi</creatorcontrib><creatorcontrib>Shima, Fumio</creatorcontrib><creatorcontrib>Kato, Motohiro</creatorcontrib><creatorcontrib>Kitamura, Katsutoshi</creatorcontrib><title>Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Alterations in local cerebral glucose utilization (LCGU) in conscious rats during stimulation of the striatum and the globus pallidus were investigated using the [
14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the striatum led only to contraversive head turning. Unilateral stimulation of the striatum increased LCGU bilaterally in the globus pallidus and substantia nigra pars compacta, but only ipsilaterally in the entopeduncular nucleus, substantia nigra pars reticulata and subthalamic nucleus. Similar stimulation of the globus pallidus increased LCGU in the globus pallidus, substantia nigra pars reticulata and compacta, entopeduncular nucleus, subthalamic nucleus, lateral habenular nucleus, parafascicular nucleus of the thalamus, deep layers of the superior colliculus and pedunculopontine nucleus, exclusively on the ipsilateral side. These results indicate that the electrical stimulation induces LCGU changes in the respective structures having both monosynaptic and transsynaptic neuronal inputs. Some changes may also be mediated by antidromic activation. They also suggest that activation of a synaptic process whether excitatory or inhibitory results in increases in LCGU. The bilateral modulatory effects of striatal stimulation may cancel out the circling behavior seen during pallidal stimulation, and cause only head turning.</description><subject>[ 14C]Deoxyglucose method</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Circling behavior</subject><subject>Corpus Striatum - metabolism</subject><subject>Corpus Striatum - physiology</subject><subject>Deoxy Sugars - metabolism</subject><subject>Deoxyglucose - metabolism</subject><subject>Electric Stimulation</subject><subject>Electrical stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - metabolism</subject><subject>Globus Pallidus - physiology</subject><subject>Local cerebral glucose utilization</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stereotyped Behavior - physiology</subject><subject>Striatum</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vFSEUhomxqbfVf6AJC2PqYioMMDCbJk3jV9KkG10TBs5UDDNc-TDR_nm5H7lLV8A5z3kPeRB6Tck1JXT4QAgZOjWO7Eqp9yPljHTqGdpQJftu6Dl5jjYn5AW6yPlnezI2knN0zpgYeyE26Ok2FEim-Lhm7FccojUBW0gwpXZ5DNXGDLgWH_zfPYZdTX59xBDAluR3eC5-qeHQjTMuP6CVkjelLtisrqXEqWa8NSF4V_d72sr8Ep3NJmR4dTwv0fdPH7_dfenuHz5_vbu97ywXfekmSomgPXOEzApGA2Z0zClrJcxcztRQ4pwZhHAcBsmcBS6AywkkTGKyI7tE7w652xR_VchFLz5bCMGsEGvWUlE5CDU0kB9Am2LOCWa9TX4x6Y-mRO-c651QvROqldJ751q1sTfH_Dot4E5DR8mt__bYN7npmpNZrc8nTA49E4I37OaAQXPx20PS2XpYLTifmmrtov__P_4B3yWg_g</recordid><startdate>19880223</startdate><enddate>19880223</enddate><creator>Aiko, Yasutaka</creator><creator>Hosokawa, Shinichi</creator><creator>Shima, Fumio</creator><creator>Kato, Motohiro</creator><creator>Kitamura, Katsutoshi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880223</creationdate><title>Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats</title><author>Aiko, Yasutaka ; Hosokawa, Shinichi ; Shima, Fumio ; Kato, Motohiro ; Kitamura, Katsutoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b1105123d00f8e9aea9d3d8cc7ef47f1a10dda655d4e673dce45e47be7eb5bc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>[ 14C]Deoxyglucose method</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Circling behavior</topic><topic>Corpus Striatum - metabolism</topic><topic>Corpus Striatum - physiology</topic><topic>Deoxy Sugars - metabolism</topic><topic>Deoxyglucose - metabolism</topic><topic>Electric Stimulation</topic><topic>Electrical stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Globus pallidus</topic><topic>Globus Pallidus - metabolism</topic><topic>Globus Pallidus - physiology</topic><topic>Local cerebral glucose utilization</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stereotyped Behavior - physiology</topic><topic>Striatum</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aiko, Yasutaka</creatorcontrib><creatorcontrib>Hosokawa, Shinichi</creatorcontrib><creatorcontrib>Shima, Fumio</creatorcontrib><creatorcontrib>Kato, Motohiro</creatorcontrib><creatorcontrib>Kitamura, Katsutoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aiko, Yasutaka</au><au>Hosokawa, Shinichi</au><au>Shima, Fumio</au><au>Kato, Motohiro</au><au>Kitamura, Katsutoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-02-23</date><risdate>1988</risdate><volume>442</volume><issue>1</issue><spage>43</spage><epage>52</epage><pages>43-52</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Alterations in local cerebral glucose utilization (LCGU) in conscious rats during stimulation of the striatum and the globus pallidus were investigated using the [
14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the striatum led only to contraversive head turning. Unilateral stimulation of the striatum increased LCGU bilaterally in the globus pallidus and substantia nigra pars compacta, but only ipsilaterally in the entopeduncular nucleus, substantia nigra pars reticulata and subthalamic nucleus. Similar stimulation of the globus pallidus increased LCGU in the globus pallidus, substantia nigra pars reticulata and compacta, entopeduncular nucleus, subthalamic nucleus, lateral habenular nucleus, parafascicular nucleus of the thalamus, deep layers of the superior colliculus and pedunculopontine nucleus, exclusively on the ipsilateral side. These results indicate that the electrical stimulation induces LCGU changes in the respective structures having both monosynaptic and transsynaptic neuronal inputs. Some changes may also be mediated by antidromic activation. They also suggest that activation of a synaptic process whether excitatory or inhibitory results in increases in LCGU. The bilateral modulatory effects of striatal stimulation may cancel out the circling behavior seen during pallidal stimulation, and cause only head turning.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3359255</pmid><doi>10.1016/0006-8993(88)91430-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research, 1988-02, Vol.442 (1), p.43-52 |
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| subjects | [ 14C]Deoxyglucose method Animals Autoradiography Biochemistry and metabolism Biological and medical sciences Central nervous system Circling behavior Corpus Striatum - metabolism Corpus Striatum - physiology Deoxy Sugars - metabolism Deoxyglucose - metabolism Electric Stimulation Electrical stimulation Fundamental and applied biological sciences. Psychology Globus pallidus Globus Pallidus - metabolism Globus Pallidus - physiology Local cerebral glucose utilization Male Rats Rats, Inbred Strains Stereotyped Behavior - physiology Striatum Vertebrates: nervous system and sense organs |
| title | Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats |
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