Deconvolution of Combinatorial Libraries for Drug Discovery:  Experimental Comparison of Pooling Strategies

An experimental evaluation of several different pooling strategies for combinatorial libraries was conducted using a library of 810 compounds and an enzyme inhibition assay (phospholipase A2). The library contained compounds with varying degrees of activity as well as inactive compounds. The compoun...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-07, Vol.39 (14), p.2720-2726
Hauptverfasser:	Wilson-Lingardo, Laura, Davis, Peter W, Ecker, David J, Hébert, Normand, Acevedo, Oscar, Sprankle, Kelly, Brennan, Thomas, Schwarcz, Leslie, Freier, Susan M, Wyatt, Jacqueline R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Evaluation, Preclinical - methods Evaluation Studies as Topic General pharmacology Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - pharmacology Phospholipases A - antagonists & inhibitors Phospholipases A2 Physicochemical properties. Structure-activity relationships
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