The organization and expression of the mdm2 gene

The mdm2 gene encodes a zinc finger protein that negatively regulates p53 function by binding and masking the p53 transcriptional activation domain. Two different promoters control expression of mdm2, one of which is also transactivated by p53. We cloned and characterized the mdm2 gene from a murine...

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Veröffentlicht in:	Genomics 1996-05, Vol.33 (3), p.352-357
Hauptverfasser:	MONTES DE OCA LUNA, R, TABOR, A. D, EBERSPAECHER, H, HULBOY, D. L, WORTH, L. L, COLMAN, M. S, FINLAY, C. A, LOZANO, G
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells AMINO ACIDS Animals Antisense Elements (Genetics) Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Brain - embryology Brain - metabolism Cloning, Molecular Cosmids DNA Primers DNA SEQUENCING DNA-CLONING Embryo, Mammalian EMBRYOS Exons Fundamental and applied biological sciences. Psychology Ganglia, Spinal - embryology Ganglia, Spinal - metabolism Gene Expression GENE MUTATIONS GENE REGULATION GENES Genes. Genome Genomic Library IN-SITU HYBRIDIZATION Introns MICE Mice, Inbred BALB C Molecular and cellular biology Molecular genetics Molecular Sequence Data Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nuclear Proteins POLYMERASE CHAIN REACTION PROTEINS Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Restriction Mapping SPLICING STRUCTURE-ACTIVITY RELATIONSHIPS TRANSCRIPTION Zinc Fingers
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