Fatty Acids of Liver, Cardiac and Adipose Tissues from Copper-Deficient Rats
The effect of copper deficiency on liver, cardiac and adipose fatty acids was studied in the Long-Evans rat. Rats were fed diets adequate in copper (8.5 mg Cu/kg diet, group AC, n = 10) or with no added copper (0.4 mg Cu/kg diet, group NC, n = 9) or were pair-fed an adequate copper diet in amounts e...
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| Veröffentlicht in: | The Journal of nutrition 1988-04, Vol.118 (4), p.480-486 |
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| description | The effect of copper deficiency on liver, cardiac and adipose fatty acids was studied in the Long-Evans rat. Rats were fed diets adequate in copper (8.5 mg Cu/kg diet, group AC, n = 10) or with no added copper (0.4 mg Cu/kg diet, group NC, n = 9) or were pair-fed an adequate copper diet in amounts eaten by group NC rats (group PF, n = 10), from weaning until 8 wk thereafter. Group NC rats exhibited typical copper deficiency signs such as decreased body weight, hematocrit and liver copper levels but increased heart/body weight ratios. Adipose and cardiac triglycerides of group NC rats had greater 18:0 to 18:1n-9 ratios. All tissues in group NC rats had higher levels of longer-chain polyunsaturated fatty acids in triglycerides than those in AC or PF rats. Specifically, the following triglyceride fatty acids were in greater concentration in NC rats than in AC or PF rats: for liver, 18:2n-6, 22:5n-6, 22:5n-3 and 22:6n-3; for cardiac, 20:3n-6, 20:4n-6, 22:5n-3 and 22:6n-3; and for adipose, 20:3n-6, 20:4n-6 and 22:5n-6. Liver phospholipids had lower levels of 20:4n-6 in NC rats than in AC or PF rats. These results suggest that copper deficiency results in the accumulation of both n-3 and n-6 longer-chain polyunsaturated fatty acids in triglycerides of various tissues. |
| doi_str_mv | 10.1093/jn/118.4.480 |
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Rats were fed diets adequate in copper (8.5 mg Cu/kg diet, group AC, n = 10) or with no added copper (0.4 mg Cu/kg diet, group NC, n = 9) or were pair-fed an adequate copper diet in amounts eaten by group NC rats (group PF, n = 10), from weaning until 8 wk thereafter. Group NC rats exhibited typical copper deficiency signs such as decreased body weight, hematocrit and liver copper levels but increased heart/body weight ratios. Adipose and cardiac triglycerides of group NC rats had greater 18:0 to 18:1n-9 ratios. All tissues in group NC rats had higher levels of longer-chain polyunsaturated fatty acids in triglycerides than those in AC or PF rats. Specifically, the following triglyceride fatty acids were in greater concentration in NC rats than in AC or PF rats: for liver, 18:2n-6, 22:5n-6, 22:5n-3 and 22:6n-3; for cardiac, 20:3n-6, 20:4n-6, 22:5n-3 and 22:6n-3; and for adipose, 20:3n-6, 20:4n-6 and 22:5n-6. Liver phospholipids had lower levels of 20:4n-6 in NC rats than in AC or PF rats. These results suggest that copper deficiency results in the accumulation of both n-3 and n-6 longer-chain polyunsaturated fatty acids in triglycerides of various tissues.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/118.4.480</identifier><identifier>PMID: 3357063</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>acide gras ; acidos grasos ; Adipose Tissue - analysis ; adipose tissues ; Administration, Oral ; Animals ; Biological and medical sciences ; Body Weight ; carence minerale ; cobre ; coeur ; composicion ; composition ; copper ; Copper - administration & dosage ; Copper - deficiency ; corazon ; cuivre ; deficiencia de minerales ; diet ; dieta ; fatty acids ; Fatty Acids - analysis ; foie ; Fundamental and applied biological sciences. Psychology ; heart ; higado ; lipids ; liver ; Liver - analysis ; Male ; Metabolisms and neurohumoral controls ; mineral deficiencies ; Myocardium - analysis ; Phospholipids - analysis ; rat ; rata ; Rats ; regime alimentaire ; tejido adiposo ; tissu adipeux ; Triglycerides - analysis ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Water and mineral metabolism. Osmoregulation. Acidobasic balance</subject><ispartof>The Journal of nutrition, 1988-04, Vol.118 (4), p.480-486</ispartof><rights>1988 American Society for Nutrition.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-b5aae76b5234e0052c9bb2e15ddd8365591961cbdf82a88231a334f143f8684b3</citedby><cites>FETCH-LOGICAL-c423t-b5aae76b5234e0052c9bb2e15ddd8365591961cbdf82a88231a334f143f8684b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7743207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3357063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ovecka, George D.</creatorcontrib><creatorcontrib>Miller, Glenn</creatorcontrib><creatorcontrib>Medeiros, Denis M.</creatorcontrib><title>Fatty Acids of Liver, Cardiac and Adipose Tissues from Copper-Deficient Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effect of copper deficiency on liver, cardiac and adipose fatty acids was studied in the Long-Evans rat. Rats were fed diets adequate in copper (8.5 mg Cu/kg diet, group AC, n = 10) or with no added copper (0.4 mg Cu/kg diet, group NC, n = 9) or were pair-fed an adequate copper diet in amounts eaten by group NC rats (group PF, n = 10), from weaning until 8 wk thereafter. Group NC rats exhibited typical copper deficiency signs such as decreased body weight, hematocrit and liver copper levels but increased heart/body weight ratios. Adipose and cardiac triglycerides of group NC rats had greater 18:0 to 18:1n-9 ratios. All tissues in group NC rats had higher levels of longer-chain polyunsaturated fatty acids in triglycerides than those in AC or PF rats. Specifically, the following triglyceride fatty acids were in greater concentration in NC rats than in AC or PF rats: for liver, 18:2n-6, 22:5n-6, 22:5n-3 and 22:6n-3; for cardiac, 20:3n-6, 20:4n-6, 22:5n-3 and 22:6n-3; and for adipose, 20:3n-6, 20:4n-6 and 22:5n-6. Liver phospholipids had lower levels of 20:4n-6 in NC rats than in AC or PF rats. These results suggest that copper deficiency results in the accumulation of both n-3 and n-6 longer-chain polyunsaturated fatty acids in triglycerides of various tissues.</description><subject>acide gras</subject><subject>acidos grasos</subject><subject>Adipose Tissue - analysis</subject><subject>adipose tissues</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>carence minerale</subject><subject>cobre</subject><subject>coeur</subject><subject>composicion</subject><subject>composition</subject><subject>copper</subject><subject>Copper - administration & dosage</subject><subject>Copper - deficiency</subject><subject>corazon</subject><subject>cuivre</subject><subject>deficiencia de minerales</subject><subject>diet</subject><subject>dieta</subject><subject>fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>foie</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>heart</subject><subject>higado</subject><subject>lipids</subject><subject>liver</subject><subject>Liver - analysis</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>mineral deficiencies</subject><subject>Myocardium - analysis</subject><subject>Phospholipids - analysis</subject><subject>rat</subject><subject>rata</subject><subject>Rats</subject><subject>regime alimentaire</subject><subject>tejido adiposo</subject><subject>tissu adipeux</subject><subject>Triglycerides - analysis</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Water and mineral metabolism. Osmoregulation. Acidobasic balance</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1rGzEQgGFRWlIn7a3XFh1KTllnRtJqtUfjJm3BUMjHWWj1UWTs1VZaB_Lvq2CTU05zmIdheAn5grBE6Pn1drxGVEuxFArekQW2AhuJAO_JAoCxhqOUH8l5KVsAQNGrM3LGeduB5AuyuTXz_ExXNrpCU6Cb-OTzFV2b7KKx1IyOrlycUvH0IZZy8IWGnPZ0nabJ5-aHD9FGP870zszlE_kQzK74z6d5QR5vbx7Wv5rNn5-_16tNYwXjczO0xvhODi3jwgO0zPbDwDy2zjnFZdv22Eu0gwuKGaUYR8O5CCh4UFKJgV-Qy-PdKad_9aVZ72Oxfrczo0-HojuFHQOJFV4doc2plOyDnnLcm_ysEfRLPL0ddY2nha7xKv96unsY9t694lOtuv9-2ptizS5kM9pYXlnXCc6gq-zbkQWTtPmbK3m8x171AHXftxXII_A10lP0WZeXiNa7mL2dtUvx7Qf_A3LIkDo</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Ovecka, George D.</creator><creator>Miller, Glenn</creator><creator>Medeiros, Denis M.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Fatty Acids of Liver, Cardiac and Adipose Tissues from Copper-Deficient Rats</title><author>Ovecka, George D. ; Miller, Glenn ; Medeiros, Denis M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-b5aae76b5234e0052c9bb2e15ddd8365591961cbdf82a88231a334f143f8684b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>acide gras</topic><topic>acidos grasos</topic><topic>Adipose Tissue - analysis</topic><topic>adipose tissues</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>carence minerale</topic><topic>cobre</topic><topic>coeur</topic><topic>composicion</topic><topic>composition</topic><topic>copper</topic><topic>Copper - administration & dosage</topic><topic>Copper - deficiency</topic><topic>corazon</topic><topic>cuivre</topic><topic>deficiencia de minerales</topic><topic>diet</topic><topic>dieta</topic><topic>fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>foie</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>heart</topic><topic>higado</topic><topic>lipids</topic><topic>liver</topic><topic>Liver - analysis</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>mineral deficiencies</topic><topic>Myocardium - analysis</topic><topic>Phospholipids - analysis</topic><topic>rat</topic><topic>rata</topic><topic>Rats</topic><topic>regime alimentaire</topic><topic>tejido adiposo</topic><topic>tissu adipeux</topic><topic>Triglycerides - analysis</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Water and mineral metabolism. Osmoregulation. Acidobasic balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovecka, George D.</creatorcontrib><creatorcontrib>Miller, Glenn</creatorcontrib><creatorcontrib>Medeiros, Denis M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovecka, George D.</au><au>Miller, Glenn</au><au>Medeiros, Denis M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty Acids of Liver, Cardiac and Adipose Tissues from Copper-Deficient Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>118</volume><issue>4</issue><spage>480</spage><epage>486</epage><pages>480-486</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effect of copper deficiency on liver, cardiac and adipose fatty acids was studied in the Long-Evans rat. Rats were fed diets adequate in copper (8.5 mg Cu/kg diet, group AC, n = 10) or with no added copper (0.4 mg Cu/kg diet, group NC, n = 9) or were pair-fed an adequate copper diet in amounts eaten by group NC rats (group PF, n = 10), from weaning until 8 wk thereafter. Group NC rats exhibited typical copper deficiency signs such as decreased body weight, hematocrit and liver copper levels but increased heart/body weight ratios. Adipose and cardiac triglycerides of group NC rats had greater 18:0 to 18:1n-9 ratios. All tissues in group NC rats had higher levels of longer-chain polyunsaturated fatty acids in triglycerides than those in AC or PF rats. Specifically, the following triglyceride fatty acids were in greater concentration in NC rats than in AC or PF rats: for liver, 18:2n-6, 22:5n-6, 22:5n-3 and 22:6n-3; for cardiac, 20:3n-6, 20:4n-6, 22:5n-3 and 22:6n-3; and for adipose, 20:3n-6, 20:4n-6 and 22:5n-6. Liver phospholipids had lower levels of 20:4n-6 in NC rats than in AC or PF rats. These results suggest that copper deficiency results in the accumulation of both n-3 and n-6 longer-chain polyunsaturated fatty acids in triglycerides of various tissues.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>3357063</pmid><doi>10.1093/jn/118.4.480</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1988-04, Vol.118 (4), p.480-486 |
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| subjects | acide gras acidos grasos Adipose Tissue - analysis adipose tissues Administration, Oral Animals Biological and medical sciences Body Weight carence minerale cobre coeur composicion composition copper Copper - administration & dosage Copper - deficiency corazon cuivre deficiencia de minerales diet dieta fatty acids Fatty Acids - analysis foie Fundamental and applied biological sciences. Psychology heart higado lipids liver Liver - analysis Male Metabolisms and neurohumoral controls mineral deficiencies Myocardium - analysis Phospholipids - analysis rat rata Rats regime alimentaire tejido adiposo tissu adipeux Triglycerides - analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance |
| title | Fatty Acids of Liver, Cardiac and Adipose Tissues from Copper-Deficient Rats |
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