Quantitation of the Putative Neurotransmitter Agmatine as the Hexafluoroacetylacetonate Derivative by Stable Isotope Dilution Gas Chromatography and Negative-Ion Chemical Ionization Mass Spectrometry

A method is described for detection and quantitation of agmatine [4-(aminobutyl)guanidine] by gas chromatography/negative-ion chemical ionization/mass spectrometry after derivatization with hexafluoroacetylacetone. The lower limit of detection of the derivative was about 25 fmol on-column. For quant...

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Veröffentlicht in:	Analytical biochemistry 1996-07, Vol.238 (2), p.129-136
Hauptverfasser:	Stickle, Douglas, Bohrer, Alan, Berger, Richard, Morrissey, Jeremiah, Klahr, Saulo, Turk, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine - analysis Animals Cerebellum - chemistry Cerebral Cortex - chemistry Gas Chromatography-Mass Spectrometry - methods Islets of Langerhans - chemistry Isotope Labeling Kidney - chemistry Male Neurotransmitter Agents - analysis Rats Rats, Sprague-Dawley Spleen - chemistry
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