Mitogenic stimulation of malignant B cells CLL: Diminished in-vitro stimulation with anti-CR1 antibodies

Peripheral B lymphocytes of five CLL patients were tested in a radioimmunoassay to determine the density of the C3b receptor (CR1) and the cells were assayed for their ability to mature into IgM secreting cells after in-vitro culture with a combination of Pokeweed Mitogen (PWM) and antibodies direct...

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Veröffentlicht in:	Leukemia research 1988, Vol.12 (2), p.109-111
Hauptverfasser:	Bloem, Andries C., Chand, M.Anwar, Daha, Mohamed R., Bast, Bert J.E.G., Ballieux, Rudy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-CR1 antibodies Antibodies - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological and medical sciences Chronic lymphocytic leukemia Hematologic and hematopoietic diseases Humans Immunoglobulin M - metabolism Leukemia, Lymphoid - immunology Leukemia, Lymphoid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation - drug effects Medical sciences Pokeweed Mitogens - pharmacology Receptors, Complement - immunology Receptors, Complement 3b stimulation
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