Regional variation in skin blood flow response to hypoglycaemia in type 1 (insulin-dependent) diabetic patients without complications
Body temperature falls during hypoglycaemia, perhaps as a protective mechanism. To test the hypothesis that the skin blood flow response to hypoglycaemia is specifically designed to facilitate heat loss we studied both nutritional blood flow and arteriovenous shunting of blood in skin during prolong...
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| Veröffentlicht in: | Diabetologia 1988-02, Vol.31 (2), p.98-102 |
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| creator | WILES, P. G GRANT, P. J STICKLAND, M. H DEAN, H. G WALES, J. K DAVIES, J. A |
| description | Body temperature falls during hypoglycaemia, perhaps as a protective mechanism. To test the hypothesis that the skin blood flow response to hypoglycaemia is specifically designed to facilitate heat loss we studied both nutritional blood flow and arteriovenous shunting of blood in skin during prolonged, controlled hypoglycaemia in man. We studied eight otherwise healthy, male, Type 1 (insulin-dependent) diabetic patients. Under Biostator control blood glucose was clamped at 8.0 (7.9-8.9), mmol/l (median and range) for 30 min, reduced to symptomatic hypoglycaemia, 1.7 (1.0-2.6) mmol/l for 20 min then raised to 4.9 (3.3-6.7) mmol/l. Interdigital skin web blood flow (laser doppler flowmeter, nutritional flow) fell during hypoglycaemia from 3.1 (2.2-3.8) to 2.4 (1.2-2.8) volts and remained depressed. In contrast, finger blood flow (venous occlusion plethysmography, arteriovenous shunt flow) started high at 54.7 (17.4-85.6), remained high at 52.7 (38.1-81.4) during hypoglycaemia but fell sharply to 25.3 (4.2-66.2) ml.min-1.100 ml-1 when symptoms were relieved. Plasma adrenaline and vasopressin both rose during hypoglycaemia from 0.4 (0.05-0.8) to 4.5 (2.3-20.2) nmol/l and from 0.5 (0.5-3.5) to 4.4 (2.0-13.9) pg/ml, respectively, and both fell sharply thereafter. |
| doi_str_mv | 10.1007/BF00395555 |
| format | Article |
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G ; GRANT, P. J ; STICKLAND, M. H ; DEAN, H. G ; WALES, J. K ; DAVIES, J. A</creator><creatorcontrib>WILES, P. G ; GRANT, P. J ; STICKLAND, M. H ; DEAN, H. G ; WALES, J. K ; DAVIES, J. A</creatorcontrib><description>Body temperature falls during hypoglycaemia, perhaps as a protective mechanism. To test the hypothesis that the skin blood flow response to hypoglycaemia is specifically designed to facilitate heat loss we studied both nutritional blood flow and arteriovenous shunting of blood in skin during prolonged, controlled hypoglycaemia in man. We studied eight otherwise healthy, male, Type 1 (insulin-dependent) diabetic patients. Under Biostator control blood glucose was clamped at 8.0 (7.9-8.9), mmol/l (median and range) for 30 min, reduced to symptomatic hypoglycaemia, 1.7 (1.0-2.6) mmol/l for 20 min then raised to 4.9 (3.3-6.7) mmol/l. Interdigital skin web blood flow (laser doppler flowmeter, nutritional flow) fell during hypoglycaemia from 3.1 (2.2-3.8) to 2.4 (1.2-2.8) volts and remained depressed. In contrast, finger blood flow (venous occlusion plethysmography, arteriovenous shunt flow) started high at 54.7 (17.4-85.6), remained high at 52.7 (38.1-81.4) during hypoglycaemia but fell sharply to 25.3 (4.2-66.2) ml.min-1.100 ml-1 when symptoms were relieved. Plasma adrenaline and vasopressin both rose during hypoglycaemia from 0.4 (0.05-0.8) to 4.5 (2.3-20.2) nmol/l and from 0.5 (0.5-3.5) to 4.4 (2.0-13.9) pg/ml, respectively, and both fell sharply thereafter.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/BF00395555</identifier><identifier>PMID: 3282956</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Temperature ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epinephrine - blood ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Face ; Fingers - blood supply ; Forearm - blood supply ; Heart Rate ; Humans ; Hypoglycemia - etiology ; Hypoglycemia - physiopathology ; Insulin - blood ; Insulin, Regular, Pork ; Male ; Medical sciences ; Regional Blood Flow ; Skin - blood supply ; Vasopressins - blood</subject><ispartof>Diabetologia, 1988-02, Vol.31 (2), p.98-102</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2625-de2a96b6fda03804d2b7aea941f67bd026f7691dcb0f6505c5d6372b3587d4463</citedby><cites>FETCH-LOGICAL-c2625-de2a96b6fda03804d2b7aea941f67bd026f7691dcb0f6505c5d6372b3587d4463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7798253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3282956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WILES, P. G</creatorcontrib><creatorcontrib>GRANT, P. J</creatorcontrib><creatorcontrib>STICKLAND, M. H</creatorcontrib><creatorcontrib>DEAN, H. G</creatorcontrib><creatorcontrib>WALES, J. K</creatorcontrib><creatorcontrib>DAVIES, J. A</creatorcontrib><title>Regional variation in skin blood flow response to hypoglycaemia in type 1 (insulin-dependent) diabetic patients without complications</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Body temperature falls during hypoglycaemia, perhaps as a protective mechanism. To test the hypothesis that the skin blood flow response to hypoglycaemia is specifically designed to facilitate heat loss we studied both nutritional blood flow and arteriovenous shunting of blood in skin during prolonged, controlled hypoglycaemia in man. We studied eight otherwise healthy, male, Type 1 (insulin-dependent) diabetic patients. Under Biostator control blood glucose was clamped at 8.0 (7.9-8.9), mmol/l (median and range) for 30 min, reduced to symptomatic hypoglycaemia, 1.7 (1.0-2.6) mmol/l for 20 min then raised to 4.9 (3.3-6.7) mmol/l. Interdigital skin web blood flow (laser doppler flowmeter, nutritional flow) fell during hypoglycaemia from 3.1 (2.2-3.8) to 2.4 (1.2-2.8) volts and remained depressed. In contrast, finger blood flow (venous occlusion plethysmography, arteriovenous shunt flow) started high at 54.7 (17.4-85.6), remained high at 52.7 (38.1-81.4) during hypoglycaemia but fell sharply to 25.3 (4.2-66.2) ml.min-1.100 ml-1 when symptoms were relieved. Plasma adrenaline and vasopressin both rose during hypoglycaemia from 0.4 (0.05-0.8) to 4.5 (2.3-20.2) nmol/l and from 0.5 (0.5-3.5) to 4.4 (2.0-13.9) pg/ml, respectively, and both fell sharply thereafter.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Temperature</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epinephrine - blood</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Face</subject><subject>Fingers - blood supply</subject><subject>Forearm - blood supply</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hypoglycemia - etiology</subject><subject>Hypoglycemia - physiopathology</subject><subject>Insulin - blood</subject><subject>Insulin, Regular, Pork</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Regional Blood Flow</subject><subject>Skin - blood supply</subject><subject>Vasopressins - blood</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtLxDAQhYMo63p58V3Ig4gK1VyapH1U8QaCIAq-lTRJd6NpUptW2R_g_zari87DzDDn4wwcAPYwOsUIibOLa4RoyVKtgSnOKclQTop1MEUIkwwX_GUTbMX4ihLGcj4BE0oKUjI-BV-PZmaDlw5-yN7KIe3QehjfUqtdCBo2LnzC3sQu-GjgEOB80YWZWyhpWiuX8LDoDMTwyPo4OuszbTrjtfHDMdRW1mawCnbJOl0i_LTDPIwDVKHtnFU_H-MO2Giki2Z3NbfB8_XV0-Vtdv9wc3d5fp8pwglLxkSWvOaNlogWKNekFtLIMscNF7VGhDeCl1irGjWcIaaY5lSQmrJC6DzndBsc_vp2fXgfTRyq1kZlnJPehDFWosAC5Ywl8OQXVH2IsTdN1fW2lf2iwqhaZl79Z57g_ZXrWLdG_6GrkJN-sNJlVNI1vfTKxj9MiLIgjNJvZWKKvg</recordid><startdate>198802</startdate><enddate>198802</enddate><creator>WILES, P. G</creator><creator>GRANT, P. J</creator><creator>STICKLAND, M. H</creator><creator>DEAN, H. G</creator><creator>WALES, J. K</creator><creator>DAVIES, J. A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198802</creationdate><title>Regional variation in skin blood flow response to hypoglycaemia in type 1 (insulin-dependent) diabetic patients without complications</title><author>WILES, P. G ; GRANT, P. J ; STICKLAND, M. H ; DEAN, H. G ; WALES, J. K ; DAVIES, J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2625-de2a96b6fda03804d2b7aea941f67bd026f7691dcb0f6505c5d6372b3587d4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Temperature</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epinephrine - blood</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Face</topic><topic>Fingers - blood supply</topic><topic>Forearm - blood supply</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hypoglycemia - etiology</topic><topic>Hypoglycemia - physiopathology</topic><topic>Insulin - blood</topic><topic>Insulin, Regular, Pork</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Regional Blood Flow</topic><topic>Skin - blood supply</topic><topic>Vasopressins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WILES, P. G</creatorcontrib><creatorcontrib>GRANT, P. J</creatorcontrib><creatorcontrib>STICKLAND, M. H</creatorcontrib><creatorcontrib>DEAN, H. G</creatorcontrib><creatorcontrib>WALES, J. K</creatorcontrib><creatorcontrib>DAVIES, J. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WILES, P. G</au><au>GRANT, P. J</au><au>STICKLAND, M. H</au><au>DEAN, H. G</au><au>WALES, J. K</au><au>DAVIES, J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional variation in skin blood flow response to hypoglycaemia in type 1 (insulin-dependent) diabetic patients without complications</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>1988-02</date><risdate>1988</risdate><volume>31</volume><issue>2</issue><spage>98</spage><epage>102</epage><pages>98-102</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Body temperature falls during hypoglycaemia, perhaps as a protective mechanism. To test the hypothesis that the skin blood flow response to hypoglycaemia is specifically designed to facilitate heat loss we studied both nutritional blood flow and arteriovenous shunting of blood in skin during prolonged, controlled hypoglycaemia in man. We studied eight otherwise healthy, male, Type 1 (insulin-dependent) diabetic patients. Under Biostator control blood glucose was clamped at 8.0 (7.9-8.9), mmol/l (median and range) for 30 min, reduced to symptomatic hypoglycaemia, 1.7 (1.0-2.6) mmol/l for 20 min then raised to 4.9 (3.3-6.7) mmol/l. Interdigital skin web blood flow (laser doppler flowmeter, nutritional flow) fell during hypoglycaemia from 3.1 (2.2-3.8) to 2.4 (1.2-2.8) volts and remained depressed. In contrast, finger blood flow (venous occlusion plethysmography, arteriovenous shunt flow) started high at 54.7 (17.4-85.6), remained high at 52.7 (38.1-81.4) during hypoglycaemia but fell sharply to 25.3 (4.2-66.2) ml.min-1.100 ml-1 when symptoms were relieved. Plasma adrenaline and vasopressin both rose during hypoglycaemia from 0.4 (0.05-0.8) to 4.5 (2.3-20.2) nmol/l and from 0.5 (0.5-3.5) to 4.4 (2.0-13.9) pg/ml, respectively, and both fell sharply thereafter.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3282956</pmid><doi>10.1007/BF00395555</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetologia, 1988-02, Vol.31 (2), p.98-102 |
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| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Body Temperature Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epinephrine - blood Etiopathogenesis. Screening. Investigations. Target tissue resistance Face Fingers - blood supply Forearm - blood supply Heart Rate Humans Hypoglycemia - etiology Hypoglycemia - physiopathology Insulin - blood Insulin, Regular, Pork Male Medical sciences Regional Blood Flow Skin - blood supply Vasopressins - blood |
| title | Regional variation in skin blood flow response to hypoglycaemia in type 1 (insulin-dependent) diabetic patients without complications |
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