The binding site for C1q on IgG

In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the a...

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Veröffentlicht in:	Nature (London) 1988-04, Vol.332 (6166), p.738-740
Hauptverfasser:	Duncan, Alexander R, Winter, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Binding Sites Biological and medical sciences Chemicals Complement Activating Enzymes - genetics Complement Activating Enzymes - immunology Complement C1 - genetics Complement C1 - immunology Complement C1q Cytotoxicity Fundamental and applied biological sciences. Psychology Fundamental immunology Hemolysis Humans Immunoglobulin Fc Fragments Immunoglobulin G - immunology Medical research Mice Molecular immunology Mutation Protein Binding Protein Conformation Stems
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