Oral Flecainide Pharmacokinetics in Patients with Impaired Renal Function

The pharmacokinetics of flecainide acetate were studied in 20 patients with varying degrees of renal impairment following a single oral dose. The patients were divided into two groups, on the basis of renal creatinine clearance (CLCR), for statistical and kinetic analysis. Patients with a CLCR betwe...

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Veröffentlicht in:	Journal of clinical pharmacology 1988-03, Vol.28 (3), p.259-267
Hauptverfasser:	Forland, Steven C., Burgess, Ellen, Blair, Andrew D., Cutler, Ralph E., Kvam, Donald C., Weeks, C. E., Fox, J. M., Conard, Gordon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Antiarythmic agents Biological and medical sciences Cardiovascular system Creatinine - metabolism Creatinine - urine Dose-Response Relationship, Drug Female Flecainide - administration & dosage Flecainide - blood Flecainide - pharmacokinetics Flecainide - urine Half-Life Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - urine Male Medical sciences Middle Aged Pharmacology. Drug treatments Renal Dialysis
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