Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production

Treatment of Ehrlich ascites cells with 2 mM oleic acid causes a greater than 10-fold increase in the formation of platelet-activating factor (PAF; 1-[3H]alkyl-2-acetyl-sn-glycero-3-phosphocholine) from the de novo precursor of PAF, 1-[3H]alkyl-2-acetyl-sn-glycerol. Under these conditions, CTP:phosp...

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Veröffentlicht in:	The Journal of biological chemistry 1988-04, Vol.263 (12), p.5656-5661
Hauptverfasser:	Blank, M L, Lee, Y J, Cress, E A, Snyder, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Carcinoma, Ehrlich Tumor - enzymology Choline-Phosphate Cytidylyltransferase Chromatography, High Pressure Liquid Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Glyceryl Ethers - metabolism Kinetics Mice Microsomes - enzymology Molecular and cellular biology Nucleotidyltransferases - antagonists & inhibitors Nucleotidyltransferases - metabolism Oleic Acid Oleic Acids - pharmacology Phenylmethylsulfonyl Fluoride - pharmacology Phosphatidylcholines - biosynthesis Platelet Platelet Activating Factor - biosynthesis Tumor Cells, Cultured
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