Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss
Omega-3 fatty acids have been implicated in the amelioration of cardiovascular disease in humans. Since these fatty acids are found in salmonid fish and are known to be essential for all salmonids, this study was undertaken to determine the effect of a high dietary intake of omega-3 fatty acids on t...
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| Veröffentlicht in: | Cardiovascular research 1996-02, Vol.31 (2), p.249-262 |
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| description | Omega-3 fatty acids have been implicated in the amelioration of cardiovascular disease in humans. Since these fatty acids are found in salmonid fish and are known to be essential for all salmonids, this study was undertaken to determine the effect of a high dietary intake of omega-3 fatty acids on the function of trout myocardium.
Rainbow trout (Oncorhynchus mykiss) from a single stock population were divided into two groups and fed either a diet high in omega-3 fatty acids (i.e. 4.0%) or low in omega-3 fatty acids (i.e. 2.1%) for 3 months. Heart function was studied at the whole heart and isolated muscle level.
In whole heart preparations, peak developed pressures in freely ejecting hearts from salmonids fed the high omega-3 fatty acid diet were significantly greater than the hearts from salmonids fed the low omega-3 fatty acid diet (21 +/- 1.5 vs. 11.5 +/- 0.9 mmHg respectively, P < 0.05). These data correlated with results from isolated muscle preparations of myocardium from fish fed high and low omega-3 fatty acid diets (4.12 +/- 0.32 vs. 3.08 +/- 0.28 mN/mm2 respectively, P < 0.05). The calcium uptake rate of heart homogenates from fish fed the high omega-3 diet was slower and sarcoplasmic reticulum Ca2+ ATPase activity was lower. The myofilament force-calcium relationship in myocardium from trout fed the low omega-3 diet was shifted leftward on the calcium axis to lower intracellular calcium concentrations (delta 0.4 pCa units) compared to mammalian myocardium. This resulted in greater activation at lower intracellular calcium concentrations. However, trouts fed diets high in omega-3 fatty acids had [Ca2+] required for half maximal activation more similar to what has been reported for mammalian myocardium (delta 0.1 pCa unit). Furthermore, the myofilaments of trout hearts appear to show less cooperativity (Hill coefficient approximately 1) than has been found in mammalian myocardium (Hill coefficient > or = 2).
Our experimental results demonstrate for the first time that dietary omega-3 fatty acid content affects myocardial force of contraction by affecting calcium metabolism and myofilament calcium-activation. |
| doi_str_mv | 10.1016/0008-6363(95)00195-6 |
| format | Article |
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Rainbow trout (Oncorhynchus mykiss) from a single stock population were divided into two groups and fed either a diet high in omega-3 fatty acids (i.e. 4.0%) or low in omega-3 fatty acids (i.e. 2.1%) for 3 months. Heart function was studied at the whole heart and isolated muscle level.
In whole heart preparations, peak developed pressures in freely ejecting hearts from salmonids fed the high omega-3 fatty acid diet were significantly greater than the hearts from salmonids fed the low omega-3 fatty acid diet (21 +/- 1.5 vs. 11.5 +/- 0.9 mmHg respectively, P < 0.05). These data correlated with results from isolated muscle preparations of myocardium from fish fed high and low omega-3 fatty acid diets (4.12 +/- 0.32 vs. 3.08 +/- 0.28 mN/mm2 respectively, P < 0.05). The calcium uptake rate of heart homogenates from fish fed the high omega-3 diet was slower and sarcoplasmic reticulum Ca2+ ATPase activity was lower. The myofilament force-calcium relationship in myocardium from trout fed the low omega-3 diet was shifted leftward on the calcium axis to lower intracellular calcium concentrations (delta 0.4 pCa units) compared to mammalian myocardium. This resulted in greater activation at lower intracellular calcium concentrations. However, trouts fed diets high in omega-3 fatty acids had [Ca2+] required for half maximal activation more similar to what has been reported for mammalian myocardium (delta 0.1 pCa unit). Furthermore, the myofilaments of trout hearts appear to show less cooperativity (Hill coefficient approximately 1) than has been found in mammalian myocardium (Hill coefficient > or = 2).
Our experimental results demonstrate for the first time that dietary omega-3 fatty acid content affects myocardial force of contraction by affecting calcium metabolism and myofilament calcium-activation.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1016/0008-6363(95)00195-6</identifier><identifier>PMID: 8730402</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Actin Cytoskeleton - physiology ; Angiotensin II - pharmacology ; Animals ; Biological and medical sciences ; Calcium - metabolism ; Calcium-Transporting ATPases - metabolism ; Diet ; Endothelins - pharmacology ; Fatty Acids, Omega-3 - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - drug effects ; Heart - physiology ; Heart - physiopathology ; Hypoxia - physiopathology ; In Vitro Techniques ; Myocardial Contraction - physiology ; Oncorhynchus mykiss - physiology ; Sarcoplasmic Reticulum - enzymology ; Statistics, Nonparametric ; Vertebrates: cardiovascular system</subject><ispartof>Cardiovascular research, 1996-02, Vol.31 (2), p.249-262</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-6aded52f292c2423bd7aa324ed542ed036b9df026aa6659f5f3ed82be01d8d873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3020539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8730402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAIGE, J. A</creatorcontrib><creatorcontrib>LIAO, R</creatorcontrib><creatorcontrib>HAJJAR, R. J</creatorcontrib><creatorcontrib>FOISY, R. L</creatorcontrib><creatorcontrib>CORY, C. R</creatorcontrib><creatorcontrib>O'BRIEN, P. J</creatorcontrib><creatorcontrib>GWATHMEY, J. K</creatorcontrib><title>Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Omega-3 fatty acids have been implicated in the amelioration of cardiovascular disease in humans. Since these fatty acids are found in salmonid fish and are known to be essential for all salmonids, this study was undertaken to determine the effect of a high dietary intake of omega-3 fatty acids on the function of trout myocardium.
Rainbow trout (Oncorhynchus mykiss) from a single stock population were divided into two groups and fed either a diet high in omega-3 fatty acids (i.e. 4.0%) or low in omega-3 fatty acids (i.e. 2.1%) for 3 months. Heart function was studied at the whole heart and isolated muscle level.
In whole heart preparations, peak developed pressures in freely ejecting hearts from salmonids fed the high omega-3 fatty acid diet were significantly greater than the hearts from salmonids fed the low omega-3 fatty acid diet (21 +/- 1.5 vs. 11.5 +/- 0.9 mmHg respectively, P < 0.05). These data correlated with results from isolated muscle preparations of myocardium from fish fed high and low omega-3 fatty acid diets (4.12 +/- 0.32 vs. 3.08 +/- 0.28 mN/mm2 respectively, P < 0.05). The calcium uptake rate of heart homogenates from fish fed the high omega-3 diet was slower and sarcoplasmic reticulum Ca2+ ATPase activity was lower. The myofilament force-calcium relationship in myocardium from trout fed the low omega-3 diet was shifted leftward on the calcium axis to lower intracellular calcium concentrations (delta 0.4 pCa units) compared to mammalian myocardium. This resulted in greater activation at lower intracellular calcium concentrations. However, trouts fed diets high in omega-3 fatty acids had [Ca2+] required for half maximal activation more similar to what has been reported for mammalian myocardium (delta 0.1 pCa unit). Furthermore, the myofilaments of trout hearts appear to show less cooperativity (Hill coefficient approximately 1) than has been found in mammalian myocardium (Hill coefficient > or = 2).
Our experimental results demonstrate for the first time that dietary omega-3 fatty acid content affects myocardial force of contraction by affecting calcium metabolism and myofilament calcium-activation.</description><subject>Actin Cytoskeleton - physiology</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Calcium-Transporting ATPases - metabolism</subject><subject>Diet</subject><subject>Endothelins - pharmacology</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>In Vitro Techniques</subject><subject>Myocardial Contraction - physiology</subject><subject>Oncorhynchus mykiss - physiology</subject><subject>Sarcoplasmic Reticulum - enzymology</subject><subject>Statistics, Nonparametric</subject><subject>Vertebrates: cardiovascular system</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAQhi0EKqXwBiD5gBAcAl5iJzmiik2q1AucrYmXxpCl2Okhb09Ko55GM_PNSP-H0DUlj5RQ-UQIyRPJJb8vxAMhtBCJPEFzmgmRcJaKUzQ_IufoIsbvsRUiS2dolmecpITNUfninNU97hwGXPlNhbvGbiDh2EHfDxi0N9h4OxIt1hCMB4111_YBdO9ri7c2uC400GqLfYvXre5CNbS62kXcDD8-xkt05qCO9mqqC_T1-vK5fE9W67eP5fMq0ZzTPpFgrBHMsYJpljJemgxgzDEOU2YN4bIsjCNMAkgpCicctyZnpSXU5GYMtEB3h7_b0P3ubOxV46O2dQ2t7XZRZTmVPM_lCKYHUIcuxmCd2gbfQBgUJWqvVu29qb03VQj1r1btz26m_7uyseZ4NLkc97fTHqKG2oXRiY9HjBNGBC_4H-sIgU4</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>PAIGE, J. A</creator><creator>LIAO, R</creator><creator>HAJJAR, R. J</creator><creator>FOISY, R. L</creator><creator>CORY, C. R</creator><creator>O'BRIEN, P. J</creator><creator>GWATHMEY, J. K</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss</title><author>PAIGE, J. A ; LIAO, R ; HAJJAR, R. J ; FOISY, R. L ; CORY, C. R ; O'BRIEN, P. J ; GWATHMEY, J. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-6aded52f292c2423bd7aa324ed542ed036b9df026aa6659f5f3ed82be01d8d873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Actin Cytoskeleton - physiology</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Calcium-Transporting ATPases - metabolism</topic><topic>Diet</topic><topic>Endothelins - pharmacology</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>In Vitro Techniques</topic><topic>Myocardial Contraction - physiology</topic><topic>Oncorhynchus mykiss - physiology</topic><topic>Sarcoplasmic Reticulum - enzymology</topic><topic>Statistics, Nonparametric</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAIGE, J. A</creatorcontrib><creatorcontrib>LIAO, R</creatorcontrib><creatorcontrib>HAJJAR, R. J</creatorcontrib><creatorcontrib>FOISY, R. L</creatorcontrib><creatorcontrib>CORY, C. R</creatorcontrib><creatorcontrib>O'BRIEN, P. J</creatorcontrib><creatorcontrib>GWATHMEY, J. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PAIGE, J. A</au><au>LIAO, R</au><au>HAJJAR, R. J</au><au>FOISY, R. L</au><au>CORY, C. R</au><au>O'BRIEN, P. J</au><au>GWATHMEY, J. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>31</volume><issue>2</issue><spage>249</spage><epage>262</epage><pages>249-262</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>Omega-3 fatty acids have been implicated in the amelioration of cardiovascular disease in humans. Since these fatty acids are found in salmonid fish and are known to be essential for all salmonids, this study was undertaken to determine the effect of a high dietary intake of omega-3 fatty acids on the function of trout myocardium.
Rainbow trout (Oncorhynchus mykiss) from a single stock population were divided into two groups and fed either a diet high in omega-3 fatty acids (i.e. 4.0%) or low in omega-3 fatty acids (i.e. 2.1%) for 3 months. Heart function was studied at the whole heart and isolated muscle level.
In whole heart preparations, peak developed pressures in freely ejecting hearts from salmonids fed the high omega-3 fatty acid diet were significantly greater than the hearts from salmonids fed the low omega-3 fatty acid diet (21 +/- 1.5 vs. 11.5 +/- 0.9 mmHg respectively, P < 0.05). These data correlated with results from isolated muscle preparations of myocardium from fish fed high and low omega-3 fatty acid diets (4.12 +/- 0.32 vs. 3.08 +/- 0.28 mN/mm2 respectively, P < 0.05). The calcium uptake rate of heart homogenates from fish fed the high omega-3 diet was slower and sarcoplasmic reticulum Ca2+ ATPase activity was lower. The myofilament force-calcium relationship in myocardium from trout fed the low omega-3 diet was shifted leftward on the calcium axis to lower intracellular calcium concentrations (delta 0.4 pCa units) compared to mammalian myocardium. This resulted in greater activation at lower intracellular calcium concentrations. However, trouts fed diets high in omega-3 fatty acids had [Ca2+] required for half maximal activation more similar to what has been reported for mammalian myocardium (delta 0.1 pCa unit). Furthermore, the myofilaments of trout hearts appear to show less cooperativity (Hill coefficient approximately 1) than has been found in mammalian myocardium (Hill coefficient > or = 2).
Our experimental results demonstrate for the first time that dietary omega-3 fatty acid content affects myocardial force of contraction by affecting calcium metabolism and myofilament calcium-activation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8730402</pmid><doi>10.1016/0008-6363(95)00195-6</doi><tpages>14</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Actin Cytoskeleton - physiology Angiotensin II - pharmacology Animals Biological and medical sciences Calcium - metabolism Calcium-Transporting ATPases - metabolism Diet Endothelins - pharmacology Fatty Acids, Omega-3 - administration & dosage Fundamental and applied biological sciences. Psychology Heart Heart - drug effects Heart - physiology Heart - physiopathology Hypoxia - physiopathology In Vitro Techniques Myocardial Contraction - physiology Oncorhynchus mykiss - physiology Sarcoplasmic Reticulum - enzymology Statistics, Nonparametric Vertebrates: cardiovascular system |
| title | Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss |
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