Preparation and characterization of doxorubicin-loaded sterically stabilized immunoliposomes

To compare the performance of sterically stabilized, doxorubicin-loaded liposomes with and without surface attached specific antibodies (D-SSIL and D-SSL, respectively). Small (< or = 120 nm) unilamellar liposomes were prepared composed of hydrogenated soy phosphatidylcholine, hydrogenated phosph...

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Veröffentlicht in:	Pharmaceutical research 1996-03, Vol.13 (3), p.352-359
Hauptverfasser:	EMANUEL, N, KEDAR, E, BOLOTIN, E. M, SMORODINSKY, N. I, BARENHOLZ, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Biological and medical sciences Chemistry, Pharmaceutical Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Carriers Drug Compounding Drug Stability Female General pharmacology Immunoconjugates - administration & dosage Immunoconjugates - metabolism Immunoconjugates - pharmacokinetics Immunoglobulin G - metabolism Liposomes Macrophages, Peritoneal - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Sensitivity and Specificity Tissue Distribution
Online-Zugang:	Volltext
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