Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys
Administration of either a non-competitive N-methyl-D-aspartatc (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarmic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbo...
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| Veröffentlicht in: | Neuroreport 1996-01, Vol.7 (2), p.565-568 |
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| creator | Matsuoka, Nobuya Aigner, Thomas G |
| description | Administration of either a non-competitive N-methyl-D-aspartatc (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarmic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monkeys. In the present study, low doses of these two drugs, which were ineffective when given alone, significantly impaired performance when given in combination. Moreover, the effect was greater than additive, indicating a synergistic interaction. These results suggest that interactions between cholincrgic and glutamatergic systems play an important role in regulation of visual recognition memory. |
| doi_str_mv | 10.1097/00001756-199601310-00045 |
| format | Article |
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In the present study, low doses of these two drugs, which were ineffective when given alone, significantly impaired performance when given in combination. Moreover, the effect was greater than additive, indicating a synergistic interaction. These results suggest that interactions between cholincrgic and glutamatergic systems play an important role in regulation of visual recognition memory.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199601310-00045</identifier><identifier>PMID: 8730830</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Cognition - physiology ; Dizocilpine Maleate - pharmacology ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists - pharmacology ; Female ; Fundamental and applied biological sciences. 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Psychophysiology</topic><topic>Scopolamine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuoka, Nobuya</creatorcontrib><creatorcontrib>Aigner, Thomas G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuoka, Nobuya</au><au>Aigner, Thomas G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1996-01-31</date><risdate>1996</risdate><volume>7</volume><issue>2</issue><spage>565</spage><epage>568</epage><pages>565-568</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Administration of either a non-competitive N-methyl-D-aspartatc (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarmic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monkeys. 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| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1996-01, Vol.7 (2), p.565-568 |
| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Behavioral psychophysiology Biological and medical sciences Cognition - physiology Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology Glutamic Acid - physiology Macaca mulatta Male Memory - physiology Neurotransmission and behavior Parasympathetic Nervous System - physiology Parasympatholytics - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Scopolamine - pharmacology |
| title | Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys |
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