The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)
We have defined “clinical N2” disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease p...
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| Veröffentlicht in: | The Annals of thoracic surgery 1988-04, Vol.45 (4), p.370-379 |
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| container_title | The Annals of thoracic surgery |
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| creator | Martini, Nael Kris, Mark G. Gralla, Richard J. Bains, Manjit S. McCormack, Patricia M. Kaiser, Larry R. Burt, Michael E. Zaman, Muhammad B. |
| description | We have defined “clinical N2” disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained. |
| doi_str_mv | 10.1016/S0003-4975(98)90007-8 |
| format | Article |
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Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. 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Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. 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Kris, Mark G. ; Gralla, Richard J. ; Bains, Manjit S. ; McCormack, Patricia M. ; Kaiser, Larry R. ; Burt, Michael E. ; Zaman, Muhammad B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c2b292f040cacfb6046cf797ae1a88443636ab7e659a292676800aeef90b98853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Cisplatin - administration & dosage</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - surgery</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Male</topic><topic>Mediastinum</topic><topic>Middle Aged</topic><topic>Mitomycin</topic><topic>Mitomycins - administration & dosage</topic><topic>Radiography</topic><topic>Vinblastine - administration & dosage</topic><topic>Vindesine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martini, Nael</creatorcontrib><creatorcontrib>Kris, Mark G.</creatorcontrib><creatorcontrib>Gralla, Richard J.</creatorcontrib><creatorcontrib>Bains, Manjit S.</creatorcontrib><creatorcontrib>McCormack, Patricia M.</creatorcontrib><creatorcontrib>Kaiser, Larry R.</creatorcontrib><creatorcontrib>Burt, Michael E.</creatorcontrib><creatorcontrib>Zaman, Muhammad B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martini, Nael</au><au>Kris, Mark G.</au><au>Gralla, Richard J.</au><au>Bains, Manjit S.</au><au>McCormack, Patricia M.</au><au>Kaiser, Larry R.</au><au>Burt, Michael E.</au><au>Zaman, Muhammad B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>45</volume><issue>4</issue><spage>370</spage><epage>379</epage><pages>370-379</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>We have defined “clinical N2” disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>2833188</pmid><doi>10.1016/S0003-4975(98)90007-8</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - surgery Cisplatin - administration & dosage Combined Modality Therapy Female Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - surgery Lymphatic Metastasis - diagnostic imaging Male Mediastinum Middle Aged Mitomycin Mitomycins - administration & dosage Radiography Vinblastine - administration & dosage Vindesine - administration & dosage |
| title | The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0) |
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