Comparative analysis of prognostic factors in men undergoing radical prostatectomy for adenocarcinoma of the prostate, including DNA ploidy, surgical tumor stage, prostatic specific antigen, Gleason grade, and age
One hundred consecutive men with adenocarcinoma of the prostate, treated by modified pelvic lymphadenectomy and radical retropubic prostatectomy, were evaluated, comparing DNA ploidy as determined by flow cytometry to surgical tumor stage (pT), preoperative prostatic specific antigen (PSA), Gleason...
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| Veröffentlicht in: | The Prostate 1996-07, Vol.29 (1), p.46-50 |
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| creator | Shockley, Kenneth F. Maatman, Thomas J. Carothers, George C. Warzynski, Michael J. |
| description | One hundred consecutive men with adenocarcinoma of the prostate, treated by modified pelvic lymphadenectomy and radical retropubic prostatectomy, were evaluated, comparing DNA ploidy as determined by flow cytometry to surgical tumor stage (pT), preoperative prostatic specific antigen (PSA), Gleason grade, and age at presentation, in an effort to assess the prognostic ability of DNA ploidy. There were 71 (71%) men found to have diploid tumors and 29 (29%) with nondiploid tumors. There was no statistical difference in surgical pathologic stage between these two groups (P = 0.2369). There was no statistical difference when comparing preoperative PSA between these two groups (P = 0.0925). There was no statistical difference when comparing Gleason grade between these two groups (P = 0.5807). Age at presentation was similar in both groups. Based on these findings, it is apparent that longitudinal studies of patient outcome will be necessary to fully assess the prognostic ability of DNA ploidy determined by flow cytometry in men undergoing radical prostatectomy for treatment of adenocarcinoma of the prostate gland. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0045(199607)29:1<46::AID-PROS7>3.0.CO;2-G |
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There were 71 (71%) men found to have diploid tumors and 29 (29%) with nondiploid tumors. There was no statistical difference in surgical pathologic stage between these two groups (P = 0.2369). There was no statistical difference when comparing preoperative PSA between these two groups (P = 0.0925). There was no statistical difference when comparing Gleason grade between these two groups (P = 0.5807). Age at presentation was similar in both groups. Based on these findings, it is apparent that longitudinal studies of patient outcome will be necessary to fully assess the prognostic ability of DNA ploidy determined by flow cytometry in men undergoing radical prostatectomy for treatment of adenocarcinoma of the prostate gland. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/(SICI)1097-0045(199607)29:1<46::AID-PROS7>3.0.CO;2-G</identifier><identifier>PMID: 8685055</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Age Factors ; Aged ; Biological and medical sciences ; DNA ploidy ; DNA, Neoplasm - analysis ; Flow Cytometry ; Gleason grade ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; Ploidies ; Prognosis ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; prostatic specific antigen ; Tumors of the urinary system ; Urinary tract. 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There were 71 (71%) men found to have diploid tumors and 29 (29%) with nondiploid tumors. There was no statistical difference in surgical pathologic stage between these two groups (P = 0.2369). There was no statistical difference when comparing preoperative PSA between these two groups (P = 0.0925). There was no statistical difference when comparing Gleason grade between these two groups (P = 0.5807). Age at presentation was similar in both groups. Based on these findings, it is apparent that longitudinal studies of patient outcome will be necessary to fully assess the prognostic ability of DNA ploidy determined by flow cytometry in men undergoing radical prostatectomy for treatment of adenocarcinoma of the prostate gland. © 1996 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>DNA ploidy</subject><subject>DNA, Neoplasm - analysis</subject><subject>Flow Cytometry</subject><subject>Gleason grade</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>prostatic specific antigen</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1u0zAYhiMEGmVwCUg-QGiTmuKfpE7LhFQyKBXTiljRdvbJs53MkDjFToBeKPeDs1Y5AXHkyH6-x2_8RtEZwROCMX11crXKV6cEz3iMcZKekNlsivkpnc3JWTKdzxer8_jT5_UVf8MmeJKvX9N4-SAaDQMPoxGmHMcJYfxx9MT7rxgHMaZH0VE2zVKcpqPod97UW-FEa35oJKyodt541BRo65rSNr41EhVCto3zyFhUa4s6q7QrG2NL5IQyUlQ97FvR6sDVO1Q0DgmlbSOFk8Y2teiF7Z0euHFwyapTveP8coG2VWPUbox858p7YdvVQRLYMrCHqZDEb7U0RfgQtjWltmO0rLTwjUVliBJQYRUKM0-jR4WovH52WI-jL-_fbfIP8cV6ucoXF7FMaMZjSXGWYcFIorlKsJKCK8yUkiplhNHbJFEJxTjlQqoeEZzQImNMzgpSSC3ZcfRy7w0Rv3fat1AbL3VVCaubzgPPSJoldBrAzR6U4V-80wVsnamF2wHB0LcN0LcNfXnQlwf7toHOgEAyBQhtw33bwABDvgYKy6B9fri_u621GqSHesP5i8O58OFZCyesNH7AGOEpo5gNz_PTVHr3V7T_J_tXsP1G8MZ7r_Gt_jV4hfsGU854CteXS9h8TDY31-wG3rI_NjrnBQ</recordid><startdate>199607</startdate><enddate>199607</enddate><creator>Shockley, Kenneth F.</creator><creator>Maatman, Thomas J.</creator><creator>Carothers, George C.</creator><creator>Warzynski, Michael J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199607</creationdate><title>Comparative analysis of prognostic factors in men undergoing radical prostatectomy for adenocarcinoma of the prostate, including DNA ploidy, surgical tumor stage, prostatic specific antigen, Gleason grade, and age</title><author>Shockley, Kenneth F. ; Maatman, Thomas J. ; Carothers, George C. ; Warzynski, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4287-c20880a314e7d40dca7d03ddcd53132b44d420057acd4e7da712f833c9f1fcec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>DNA ploidy</topic><topic>DNA, Neoplasm - analysis</topic><topic>Flow Cytometry</topic><topic>Gleason grade</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Ploidies</topic><topic>Prognosis</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>prostatic specific antigen</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shockley, Kenneth F.</creatorcontrib><creatorcontrib>Maatman, Thomas J.</creatorcontrib><creatorcontrib>Carothers, George C.</creatorcontrib><creatorcontrib>Warzynski, Michael J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shockley, Kenneth F.</au><au>Maatman, Thomas J.</au><au>Carothers, George C.</au><au>Warzynski, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of prognostic factors in men undergoing radical prostatectomy for adenocarcinoma of the prostate, including DNA ploidy, surgical tumor stage, prostatic specific antigen, Gleason grade, and age</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>1996-07</date><risdate>1996</risdate><volume>29</volume><issue>1</issue><spage>46</spage><epage>50</epage><pages>46-50</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>One hundred consecutive men with adenocarcinoma of the prostate, treated by modified pelvic lymphadenectomy and radical retropubic prostatectomy, were evaluated, comparing DNA ploidy as determined by flow cytometry to surgical tumor stage (pT), preoperative prostatic specific antigen (PSA), Gleason grade, and age at presentation, in an effort to assess the prognostic ability of DNA ploidy. There were 71 (71%) men found to have diploid tumors and 29 (29%) with nondiploid tumors. There was no statistical difference in surgical pathologic stage between these two groups (P = 0.2369). There was no statistical difference when comparing preoperative PSA between these two groups (P = 0.0925). There was no statistical difference when comparing Gleason grade between these two groups (P = 0.5807). Age at presentation was similar in both groups. Based on these findings, it is apparent that longitudinal studies of patient outcome will be necessary to fully assess the prognostic ability of DNA ploidy determined by flow cytometry in men undergoing radical prostatectomy for treatment of adenocarcinoma of the prostate gland. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8685055</pmid><doi>10.1002/(SICI)1097-0045(199607)29:1<46::AID-PROS7>3.0.CO;2-G</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Age Factors Aged Biological and medical sciences DNA ploidy DNA, Neoplasm - analysis Flow Cytometry Gleason grade Humans Male Medical sciences Middle Aged Neoplasm Staging Nephrology. Urinary tract diseases Ploidies Prognosis Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery prostatic specific antigen Tumors of the urinary system Urinary tract. Prostate gland |
| title | Comparative analysis of prognostic factors in men undergoing radical prostatectomy for adenocarcinoma of the prostate, including DNA ploidy, surgical tumor stage, prostatic specific antigen, Gleason grade, and age |
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