Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety

The behavioral effects of intracerebroventricular (ICV) administration of a specific mineralocorticoid receptor (MR) antagonist [RU28318 (10–50 ng/2 μl)], a glucocorticoid receptor (GR) antagonist [RU38486 (1–50 ng/2 μl)], or both antagonists (50 ng/2 μl), were studied in two different animal models...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-05, Vol.54 (1), p.261-267
Hauptverfasser:	Korte, S.Mechiel, Korte-Bouws, Gerdien A.H., Koob, George F., De Kloet, E.Ronald, Bohus, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Adult and adolescent clinical studies Animals Anxiety Anxiety - psychology Anxiety disorders. Neuroses Behavior, Animal - drug effects Biological and medical sciences Defensive burying Electroshock Fear Fear - drug effects Fear-potentiated startle Glucocorticoid receptor Hormone Antagonists - pharmacology Injections, Intraventricular Male Medical sciences Mifepristone - pharmacology Mineralocorticoid receptor Mineralocorticoid Receptor Antagonists - pharmacology Miscellaneous Motor Activity - drug effects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Wistar Receptors, Glucocorticoid - antagonists & inhibitors Reflex, Startle - drug effects Spironolactone - analogs & derivatives Spironolactone - pharmacology
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