Melatonin enhancement of [ 3H]-γ-aminobutyric acid and [ 3H]muscimol binding in rat brain
The pineal hormone, melatonin, enhanced the sodium-independent binding of [ 3H]-γ-amino-butyric acid ([ 3H]GABA) and [ 3H]muscimol in the rat cerebral cortex in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100...
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| Veröffentlicht in: | Biochemical pharmacology 1988-04, Vol.37 (7), p.1271-1274 |
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| container_end_page | 1274 |
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| container_title | Biochemical pharmacology |
| container_volume | 37 |
| creator | Coloma, Fides M. Niles, Lennard P. |
| description | The pineal hormone, melatonin, enhanced the sodium-independent binding of [
3H]-γ-amino-butyric acid ([
3H]GABA) and [
3H]muscimol in the rat cerebral cortex
in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100. Saturation binding studies using [
3H]GABA (2.5 to 1000 nM) indicated that the melatonin-induced enhancement of binding is due to an increase in low-affinity GABA
A binding sites. These findings suggest that the central effects of melatonin involve modulation of GABAergic function. |
| doi_str_mv | 10.1016/0006-2952(88)90781-2 |
| format | Article |
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3H]-γ-amino-butyric acid ([
3H]GABA) and [
3H]muscimol in the rat cerebral cortex
in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100. Saturation binding studies using [
3H]GABA (2.5 to 1000 nM) indicated that the melatonin-induced enhancement of binding is due to an increase in low-affinity GABA
A binding sites. These findings suggest that the central effects of melatonin involve modulation of GABAergic function.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(88)90781-2</identifier><identifier>PMID: 2833276</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Diazepam - pharmacology ; Dose-Response Relationship, Drug ; Freezing ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - metabolism ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; In Vitro Techniques ; Male ; Melatonin - pharmacology ; Muscimol - metabolism ; Octoxynol ; Polyethylene Glycols - pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, GABA-A - drug effects ; Tritium ; Vertebrates: endocrinology</subject><ispartof>Biochemical pharmacology, 1988-04, Vol.37 (7), p.1271-1274</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-233e781fa693abdb1cabfee91f2955cbcf5bb30c5c75f1cd55b81252e039f5b63</citedby><cites>FETCH-LOGICAL-c386t-233e781fa693abdb1cabfee91f2955cbcf5bb30c5c75f1cd55b81252e039f5b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006295288907812$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7182321$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2833276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coloma, Fides M.</creatorcontrib><creatorcontrib>Niles, Lennard P.</creatorcontrib><title>Melatonin enhancement of [ 3H]-γ-aminobutyric acid and [ 3H]muscimol binding in rat brain</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The pineal hormone, melatonin, enhanced the sodium-independent binding of [
3H]-γ-amino-butyric acid ([
3H]GABA) and [
3H]muscimol in the rat cerebral cortex
in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100. Saturation binding studies using [
3H]GABA (2.5 to 1000 nM) indicated that the melatonin-induced enhancement of binding is due to an increase in low-affinity GABA
A binding sites. These findings suggest that the central effects of melatonin involve modulation of GABAergic function.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Diazepam - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Freezing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Melatonin - pharmacology</subject><subject>Muscimol - metabolism</subject><subject>Octoxynol</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Tritium</subject><subject>Vertebrates: endocrinology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQCELEV1UczFtuhFEvIHiRjeKhCQ90UibatIKPpfv4TOZcYZZugon_3d-Dh9C25QcUkLLI0JIWbBasH0pD2pSSVqwJTShsuL5u5TLaLJA1tB6Sm_TUZZ0Fa0yyTmrygl6vIVWD33wAUN41cFCB2HAvcNPmF89Fz_fhe586M04fEVvsba-wTo0s7gbk_Vd32LjQ-PDC841UQ_YRO3DJlpxuk2wNX830MPF-f3ZVXFzd3l9dnpTWC7LoWCcQ77d6bLm2jSGWm0cQE1dPlxYY50whhMrbCUctY0QRlImGBBe56jkG2hv1vse-48R0qA6nyy0rQ7Qj0nlcsGoFBk8noE29ilFcOo9-k7HL0WJmipVU0Fq6ktJqf6UKpbXdub9o-mgWSzNHeZ8d57rZHXrYrbo0wKrqGSc0YydzDDILj49RJXdQRbe-Ah2UE3v_7_jF_2SkqU</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Coloma, Fides M.</creator><creator>Niles, Lennard P.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Melatonin enhancement of [ 3H]-γ-aminobutyric acid and [ 3H]muscimol binding in rat brain</title><author>Coloma, Fides M. ; Niles, Lennard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-233e781fa693abdb1cabfee91f2955cbcf5bb30c5c75f1cd55b81252e039f5b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Diazepam - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Freezing</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Melatonin - pharmacology</topic><topic>Muscimol - metabolism</topic><topic>Octoxynol</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Tritium</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coloma, Fides M.</creatorcontrib><creatorcontrib>Niles, Lennard P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coloma, Fides M.</au><au>Niles, Lennard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin enhancement of [ 3H]-γ-aminobutyric acid and [ 3H]muscimol binding in rat brain</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>37</volume><issue>7</issue><spage>1271</spage><epage>1274</epage><pages>1271-1274</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>The pineal hormone, melatonin, enhanced the sodium-independent binding of [
3H]-γ-amino-butyric acid ([
3H]GABA) and [
3H]muscimol in the rat cerebral cortex
in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100. Saturation binding studies using [
3H]GABA (2.5 to 1000 nM) indicated that the melatonin-induced enhancement of binding is due to an increase in low-affinity GABA
A binding sites. These findings suggest that the central effects of melatonin involve modulation of GABAergic function.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2833276</pmid><doi>10.1016/0006-2952(88)90781-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1988-04, Vol.37 (7), p.1271-1274 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Brain - drug effects Brain - metabolism Diazepam - pharmacology Dose-Response Relationship, Drug Freezing Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis In Vitro Techniques Male Melatonin - pharmacology Muscimol - metabolism Octoxynol Polyethylene Glycols - pharmacology Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Tritium Vertebrates: endocrinology |
| title | Melatonin enhancement of [ 3H]-γ-aminobutyric acid and [ 3H]muscimol binding in rat brain |
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