Hypoxemia During Hemodialysis: A Critical Review of the Facts
The literature describing the fall in PaO2 during dialysis is intensively and critically reviewed. This phenomenon is related to both the type of membrane used (cellulosic v noncellulosic membrane), and to the composition of the dialysate (acetate v bicarbonate). It appears that a ventilation/perfus...
Gespeichert in:
| Veröffentlicht in: | American journal of kidney diseases 1988-04, Vol.11 (4), p.281-297 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 297 |
|---|---|
| container_issue | 4 |
| container_start_page | 281 |
| container_title | American journal of kidney diseases |
| container_volume | 11 |
| creator | Cardoso, M. Vinay, P. Vinet, B. Léveillée, M. Prud'homme, M. Téjédor, A. Courteau, M. Gougoux, A. St-Louis, G. Lapierre, L. Piette, Y. |
| description | The literature describing the fall in PaO2 during dialysis is intensively and critically reviewed. This phenomenon is related to both the type of membrane used (cellulosic v noncellulosic membrane), and to the composition of the dialysate (acetate v bicarbonate). It appears that a ventilation/perfusion mismatch due to pulmonary leukostasis can, in part, explain hypoxemia in patients dialyzed with cellulosic membranes. This phenomenon is especially apparent in patients with preexisting pulmonary abnormalities. However, hypoventilation remains the major cause of hypoxemia. This hypoventilation is mainly due to CO2 consumption during acetate metabolism (acetate dialysis), or alkalinization of the blood (bicarbonate dialysis). The metabolic consequences of acetate metabolism, and of bicarbonate and CO2 losses through the dialyzer are critically analyzed. The cause for the increment in oxygen consumption during acetate dialysis is examined. Finally, the respective role of these combined factors are described and used to explain the changes in VCO2, VO2, respiratory quotient (RQ), and PaO2 reported in the literature during dialysis against acetate and/or bicarbonate. |
| doi_str_mv | 10.1016/S0272-6386(88)80133-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78151675</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0272638688801331</els_id><sourcerecordid>78151675</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-692cafda0ff455de94ac178f0e9a23af91314a878ff2a88f5afc3cdd7533ab263</originalsourceid><addsrcrecordid>eNqFkE9LAzEQxYMotVY_QiEn0cNqsummWUGkVGuFguCfc5gmE43sdmuyq_bbu7WlV08D896bx_wI6XN2wRmXl88sHaaJFEqeKXWuGBci4Xuky7NUJFIJtU-6O8shOYrxgzGWCyk7pCN4qjjLu-R6ulpWP1h6oLdN8Is3OsWysh6KVfTxio7oOPjaGyjoE355_KaVo_U70gmYOh6TAwdFxJPt7JHXyd3LeJrMHu8fxqNZYoRkdSLz1ICzwJwbZJnFfACGD5VjmEMqwOVc8AGoduNSUMpl4Iww1g4zIWCeStEjp5u7y1B9NhhrXfposChggVUT9VDxjMvW3iPZxmhCFWNAp5fBlxBWmjO9xqb_sOk1E62U_sOmeZvrbwuaeYl2l9pyavWbjY7tly2GoKPxuDBofUBTa1v5fxp-AWayfCQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78151675</pqid></control><display><type>article</type><title>Hypoxemia During Hemodialysis: A Critical Review of the Facts</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Cardoso, M. ; Vinay, P. ; Vinet, B. ; Léveillée, M. ; Prud'homme, M. ; Téjédor, A. ; Courteau, M. ; Gougoux, A. ; St-Louis, G. ; Lapierre, L. ; Piette, Y.</creator><creatorcontrib>Cardoso, M. ; Vinay, P. ; Vinet, B. ; Léveillée, M. ; Prud'homme, M. ; Téjédor, A. ; Courteau, M. ; Gougoux, A. ; St-Louis, G. ; Lapierre, L. ; Piette, Y.</creatorcontrib><description>The literature describing the fall in PaO2 during dialysis is intensively and critically reviewed. This phenomenon is related to both the type of membrane used (cellulosic v noncellulosic membrane), and to the composition of the dialysate (acetate v bicarbonate). It appears that a ventilation/perfusion mismatch due to pulmonary leukostasis can, in part, explain hypoxemia in patients dialyzed with cellulosic membranes. This phenomenon is especially apparent in patients with preexisting pulmonary abnormalities. However, hypoventilation remains the major cause of hypoxemia. This hypoventilation is mainly due to CO2 consumption during acetate metabolism (acetate dialysis), or alkalinization of the blood (bicarbonate dialysis). The metabolic consequences of acetate metabolism, and of bicarbonate and CO2 losses through the dialyzer are critically analyzed. The cause for the increment in oxygen consumption during acetate dialysis is examined. Finally, the respective role of these combined factors are described and used to explain the changes in VCO2, VO2, respiratory quotient (RQ), and PaO2 reported in the literature during dialysis against acetate and/or bicarbonate.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1016/S0272-6386(88)80133-1</identifier><identifier>PMID: 3128109</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Carbon Dioxide - metabolism ; Hemodialysis ; Humans ; hypoventilation ; hypoxemia ; Hypoxia - etiology ; Hypoxia - metabolism ; Hypoxia - physiopathology ; Membranes, Artificial ; Oxygen - blood ; Oxygen Consumption ; Renal Dialysis - adverse effects ; Respiration ; respiratory quotient ; ventilation/perfusion mismatch</subject><ispartof>American journal of kidney diseases, 1988-04, Vol.11 (4), p.281-297</ispartof><rights>1988 National Kidney Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-692cafda0ff455de94ac178f0e9a23af91314a878ff2a88f5afc3cdd7533ab263</citedby><cites>FETCH-LOGICAL-c360t-692cafda0ff455de94ac178f0e9a23af91314a878ff2a88f5afc3cdd7533ab263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638688801331$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3128109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardoso, M.</creatorcontrib><creatorcontrib>Vinay, P.</creatorcontrib><creatorcontrib>Vinet, B.</creatorcontrib><creatorcontrib>Léveillée, M.</creatorcontrib><creatorcontrib>Prud'homme, M.</creatorcontrib><creatorcontrib>Téjédor, A.</creatorcontrib><creatorcontrib>Courteau, M.</creatorcontrib><creatorcontrib>Gougoux, A.</creatorcontrib><creatorcontrib>St-Louis, G.</creatorcontrib><creatorcontrib>Lapierre, L.</creatorcontrib><creatorcontrib>Piette, Y.</creatorcontrib><title>Hypoxemia During Hemodialysis: A Critical Review of the Facts</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>The literature describing the fall in PaO2 during dialysis is intensively and critically reviewed. This phenomenon is related to both the type of membrane used (cellulosic v noncellulosic membrane), and to the composition of the dialysate (acetate v bicarbonate). It appears that a ventilation/perfusion mismatch due to pulmonary leukostasis can, in part, explain hypoxemia in patients dialyzed with cellulosic membranes. This phenomenon is especially apparent in patients with preexisting pulmonary abnormalities. However, hypoventilation remains the major cause of hypoxemia. This hypoventilation is mainly due to CO2 consumption during acetate metabolism (acetate dialysis), or alkalinization of the blood (bicarbonate dialysis). The metabolic consequences of acetate metabolism, and of bicarbonate and CO2 losses through the dialyzer are critically analyzed. The cause for the increment in oxygen consumption during acetate dialysis is examined. Finally, the respective role of these combined factors are described and used to explain the changes in VCO2, VO2, respiratory quotient (RQ), and PaO2 reported in the literature during dialysis against acetate and/or bicarbonate.</description><subject>Carbon Dioxide - metabolism</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>hypoventilation</subject><subject>hypoxemia</subject><subject>Hypoxia - etiology</subject><subject>Hypoxia - metabolism</subject><subject>Hypoxia - physiopathology</subject><subject>Membranes, Artificial</subject><subject>Oxygen - blood</subject><subject>Oxygen Consumption</subject><subject>Renal Dialysis - adverse effects</subject><subject>Respiration</subject><subject>respiratory quotient</subject><subject>ventilation/perfusion mismatch</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LAzEQxYMotVY_QiEn0cNqsummWUGkVGuFguCfc5gmE43sdmuyq_bbu7WlV08D896bx_wI6XN2wRmXl88sHaaJFEqeKXWuGBci4Xuky7NUJFIJtU-6O8shOYrxgzGWCyk7pCN4qjjLu-R6ulpWP1h6oLdN8Is3OsWysh6KVfTxio7oOPjaGyjoE355_KaVo_U70gmYOh6TAwdFxJPt7JHXyd3LeJrMHu8fxqNZYoRkdSLz1ICzwJwbZJnFfACGD5VjmEMqwOVc8AGoduNSUMpl4Iww1g4zIWCeStEjp5u7y1B9NhhrXfposChggVUT9VDxjMvW3iPZxmhCFWNAp5fBlxBWmjO9xqb_sOk1E62U_sOmeZvrbwuaeYl2l9pyavWbjY7tly2GoKPxuDBofUBTa1v5fxp-AWayfCQ</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Cardoso, M.</creator><creator>Vinay, P.</creator><creator>Vinet, B.</creator><creator>Léveillée, M.</creator><creator>Prud'homme, M.</creator><creator>Téjédor, A.</creator><creator>Courteau, M.</creator><creator>Gougoux, A.</creator><creator>St-Louis, G.</creator><creator>Lapierre, L.</creator><creator>Piette, Y.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Hypoxemia During Hemodialysis: A Critical Review of the Facts</title><author>Cardoso, M. ; Vinay, P. ; Vinet, B. ; Léveillée, M. ; Prud'homme, M. ; Téjédor, A. ; Courteau, M. ; Gougoux, A. ; St-Louis, G. ; Lapierre, L. ; Piette, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-692cafda0ff455de94ac178f0e9a23af91314a878ff2a88f5afc3cdd7533ab263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Carbon Dioxide - metabolism</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>hypoventilation</topic><topic>hypoxemia</topic><topic>Hypoxia - etiology</topic><topic>Hypoxia - metabolism</topic><topic>Hypoxia - physiopathology</topic><topic>Membranes, Artificial</topic><topic>Oxygen - blood</topic><topic>Oxygen Consumption</topic><topic>Renal Dialysis - adverse effects</topic><topic>Respiration</topic><topic>respiratory quotient</topic><topic>ventilation/perfusion mismatch</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, M.</creatorcontrib><creatorcontrib>Vinay, P.</creatorcontrib><creatorcontrib>Vinet, B.</creatorcontrib><creatorcontrib>Léveillée, M.</creatorcontrib><creatorcontrib>Prud'homme, M.</creatorcontrib><creatorcontrib>Téjédor, A.</creatorcontrib><creatorcontrib>Courteau, M.</creatorcontrib><creatorcontrib>Gougoux, A.</creatorcontrib><creatorcontrib>St-Louis, G.</creatorcontrib><creatorcontrib>Lapierre, L.</creatorcontrib><creatorcontrib>Piette, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardoso, M.</au><au>Vinay, P.</au><au>Vinet, B.</au><au>Léveillée, M.</au><au>Prud'homme, M.</au><au>Téjédor, A.</au><au>Courteau, M.</au><au>Gougoux, A.</au><au>St-Louis, G.</au><au>Lapierre, L.</au><au>Piette, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxemia During Hemodialysis: A Critical Review of the Facts</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>11</volume><issue>4</issue><spage>281</spage><epage>297</epage><pages>281-297</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>The literature describing the fall in PaO2 during dialysis is intensively and critically reviewed. This phenomenon is related to both the type of membrane used (cellulosic v noncellulosic membrane), and to the composition of the dialysate (acetate v bicarbonate). It appears that a ventilation/perfusion mismatch due to pulmonary leukostasis can, in part, explain hypoxemia in patients dialyzed with cellulosic membranes. This phenomenon is especially apparent in patients with preexisting pulmonary abnormalities. However, hypoventilation remains the major cause of hypoxemia. This hypoventilation is mainly due to CO2 consumption during acetate metabolism (acetate dialysis), or alkalinization of the blood (bicarbonate dialysis). The metabolic consequences of acetate metabolism, and of bicarbonate and CO2 losses through the dialyzer are critically analyzed. The cause for the increment in oxygen consumption during acetate dialysis is examined. Finally, the respective role of these combined factors are described and used to explain the changes in VCO2, VO2, respiratory quotient (RQ), and PaO2 reported in the literature during dialysis against acetate and/or bicarbonate.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3128109</pmid><doi>10.1016/S0272-6386(88)80133-1</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-6386 |
| ispartof | American journal of kidney diseases, 1988-04, Vol.11 (4), p.281-297 |
| issn | 0272-6386 1523-6838 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78151675 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Carbon Dioxide - metabolism Hemodialysis Humans hypoventilation hypoxemia Hypoxia - etiology Hypoxia - metabolism Hypoxia - physiopathology Membranes, Artificial Oxygen - blood Oxygen Consumption Renal Dialysis - adverse effects Respiration respiratory quotient ventilation/perfusion mismatch |
| title | Hypoxemia During Hemodialysis: A Critical Review of the Facts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T20%3A59%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypoxemia%20During%20Hemodialysis:%20A%20Critical%20Review%20of%20the%20Facts&rft.jtitle=American%20journal%20of%20kidney%20diseases&rft.au=Cardoso,%20M.&rft.date=1988-04-01&rft.volume=11&rft.issue=4&rft.spage=281&rft.epage=297&rft.pages=281-297&rft.issn=0272-6386&rft.eissn=1523-6838&rft_id=info:doi/10.1016/S0272-6386(88)80133-1&rft_dat=%3Cproquest_cross%3E78151675%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78151675&rft_id=info:pmid/3128109&rft_els_id=S0272638688801331&rfr_iscdi=true |