Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: Role of protein kinase C

Stimulation of the neutrophils with fMet-Leu-Phe inhibits the rise in intracellular concentration of free calcium produced by the subsequent addition of platelet-activating factor. This deactivation is not observed in pertussis toxin treated cells. In addition, preincubation of the cells with the pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1988-03, Vol.151 (2), p.836-843
Hauptverfasser:	Molski, T.F.P., Tao, W., Becker, E.L., Sha'afi, R.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzofurans Biological and medical sciences calcium Calcium - metabolism Cell physiology Fluorescent Dyes Fundamental and applied biological sciences. Psychology Fura-2 Kinetics leukocytes (neutrophilic) Membrane and intracellular transports Molecular and cellular biology N-Formylmethionine Leucyl-Phenylalanine - pharmacology N-formylmethionyl-leucyl-phenylalanine Neutrophils - drug effects Neutrophils - metabolism Pertussis Toxin Platelet Activating Factor - pharmacology protein kinase C Protein Kinase C - metabolism Rabbits Spectrometry, Fluorescence Virulence Factors, Bordetella - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!