Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen
The effect of intrathecal pretreatment with pertussis toxin on the spinal antinociceptive effect of morphine, noradrenaline and L-baclofen was examined in rats implanted with chronic indwelling cannulas. Pretreatment with 0.25–0.75 μg pertussis toxin for 2–7 days inhibited antinociception produced b...
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| Veröffentlicht in: | European journal of pharmacology 1988-01, Vol.146 (1), p.65-72 |
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| creator | Hoehn, Katja Reid, Allison Sawynok, Jana |
| description | The effect of intrathecal pretreatment with pertussis toxin on the spinal antinociceptive effect of morphine, noradrenaline and L-baclofen was examined in rats implanted with chronic indwelling cannulas. Pretreatment with 0.25–0.75 μg pertussis toxin for 2–7 days inhibited antinociception produced by intrathecal injection of all three agents in the tail flick test. Inhibition also occurred in the hot plate test, butwas less pronounced than in the tail flick test. When doses of the three agents giving similar levels of antinociception were compared in a single group, the degree of inhibition of antinociception was comparable. Inhibition of the effect of noradrenaline was observed up to 14 days following pretreatment. The sensitivity of spinal antinociception to pertussis toxin suggests involvement of a guanine nucleotide regulatory protein in spinal actions of morphine, noradrenaline and L-baclofen. There is support in the literature for the additional involvement of adenylate cyclase in the action of morphine and noradrenaline but not of baclofen. |
| doi_str_mv | 10.1016/0014-2999(88)90487-6 |
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Pretreatment with 0.25–0.75 μg pertussis toxin for 2–7 days inhibited antinociception produced by intrathecal injection of all three agents in the tail flick test. Inhibition also occurred in the hot plate test, butwas less pronounced than in the tail flick test. When doses of the three agents giving similar levels of antinociception were compared in a single group, the degree of inhibition of antinociception was comparable. Inhibition of the effect of noradrenaline was observed up to 14 days following pretreatment. The sensitivity of spinal antinociception to pertussis toxin suggests involvement of a guanine nucleotide regulatory protein in spinal actions of morphine, noradrenaline and L-baclofen. There is support in the literature for the additional involvement of adenylate cyclase in the action of morphine and noradrenaline but not of baclofen.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(88)90487-6</identifier><identifier>PMID: 3350059</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject><![CDATA[Adenylate Cyclase Toxin ; Analgesics - administration & dosage ; Analgesics - antagonists & inhibitors ; Animals ; Baclofen ; Baclofen - administration & dosage ; Baclofen - antagonists & inhibitors ; Biological and medical sciences ; Body Weight - drug effects ; Bordetella pertussis ; Fundamental and applied biological sciences. Psychology ; Injections, Spinal ; Male ; Morphine ; Morphine - administration & dosage ; Morphine - antagonists & inhibitors ; Noradrenaline ; Norepinephrine - administration & dosage ; Norepinephrine - antagonists & inhibitors ; Pertussis Toxin ; Rats ; Rats, Inbred Strains ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Tail flick test ; Vertebrates: nervous system and sense organs ; Virulence Factors, Bordetella - pharmacology]]></subject><ispartof>European journal of pharmacology, 1988-01, Vol.146 (1), p.65-72</ispartof><rights>1988</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-785431a3740374963e9755fd42e4df384a685d1f789412dd55f87e6824a7711f3</citedby><cites>FETCH-LOGICAL-c483t-785431a3740374963e9755fd42e4df384a685d1f789412dd55f87e6824a7711f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299988904876$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7788105$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3350059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoehn, Katja</creatorcontrib><creatorcontrib>Reid, Allison</creatorcontrib><creatorcontrib>Sawynok, Jana</creatorcontrib><title>Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of intrathecal pretreatment with pertussis toxin on the spinal antinociceptive effect of morphine, noradrenaline and L-baclofen was examined in rats implanted with chronic indwelling cannulas. Pretreatment with 0.25–0.75 μg pertussis toxin for 2–7 days inhibited antinociception produced by intrathecal injection of all three agents in the tail flick test. Inhibition also occurred in the hot plate test, butwas less pronounced than in the tail flick test. When doses of the three agents giving similar levels of antinociception were compared in a single group, the degree of inhibition of antinociception was comparable. Inhibition of the effect of noradrenaline was observed up to 14 days following pretreatment. The sensitivity of spinal antinociception to pertussis toxin suggests involvement of a guanine nucleotide regulatory protein in spinal actions of morphine, noradrenaline and L-baclofen. There is support in the literature for the additional involvement of adenylate cyclase in the action of morphine and noradrenaline but not of baclofen.</description><subject>Adenylate Cyclase Toxin</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - antagonists & inhibitors</subject><subject>Animals</subject><subject>Baclofen</subject><subject>Baclofen - administration & dosage</subject><subject>Baclofen - antagonists & inhibitors</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Bordetella pertussis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Noradrenaline</subject><subject>Norepinephrine - administration & dosage</subject><subject>Norepinephrine - antagonists & inhibitors</subject><subject>Pertussis Toxin</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Tail flick test</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrGzEQhUVpSN2k_6CFPYTSQjfV7GpX0iVQQtsEAskhPQtZGmGFteRK2tD8-8ix8TE9CM0w3zyG9wj5CPQcKIzfKQXWdlLKL0J8lZQJ3o5vyAIEly3l0L0liwPyjrzP-YFSOshuOCbHfT9s6wVJd5jKnLPPTYn_fGh8WPmlL7nRofgQjTe4KT6GZpOinQ3aZvlUoZJ0WaHRU60f0LwQ0TXrmDYrH_BbE2LSNmHQU22rWN3TZooOwyk5cnrK-GH_n5A_v37eX161N7e_ry9_3LSGib60XAysB91zRuuTY4-SD4OzrENmXS-YHsVgwXEhGXTW1pngOIqOac4BXH9CPu906-V_Z8xFrX02OE06YJyz4gIYHyn7LwhMUhAjVJDtQJNizgmd2iS_1ulJAVXbTNTWcLU1XAmhXjJRY137tNefl2u0h6V9CHV-tp_rXB11SQfj8wHjXAigQ8UudhhW0x49JpWNx1Aj8akmoGz0r9_xDBFVqNE</recordid><startdate>19880127</startdate><enddate>19880127</enddate><creator>Hoehn, Katja</creator><creator>Reid, Allison</creator><creator>Sawynok, Jana</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880127</creationdate><title>Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen</title><author>Hoehn, Katja ; Reid, Allison ; Sawynok, Jana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-785431a3740374963e9755fd42e4df384a685d1f789412dd55f87e6824a7711f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenylate Cyclase Toxin</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - antagonists & inhibitors</topic><topic>Animals</topic><topic>Baclofen</topic><topic>Baclofen - administration & dosage</topic><topic>Baclofen - antagonists & inhibitors</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Bordetella pertussis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Noradrenaline</topic><topic>Norepinephrine - administration & dosage</topic><topic>Norepinephrine - antagonists & inhibitors</topic><topic>Pertussis Toxin</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Tail flick test</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoehn, Katja</creatorcontrib><creatorcontrib>Reid, Allison</creatorcontrib><creatorcontrib>Sawynok, Jana</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoehn, Katja</au><au>Reid, Allison</au><au>Sawynok, Jana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1988-01-27</date><risdate>1988</risdate><volume>146</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effect of intrathecal pretreatment with pertussis toxin on the spinal antinociceptive effect of morphine, noradrenaline and L-baclofen was examined in rats implanted with chronic indwelling cannulas. Pretreatment with 0.25–0.75 μg pertussis toxin for 2–7 days inhibited antinociception produced by intrathecal injection of all three agents in the tail flick test. Inhibition also occurred in the hot plate test, butwas less pronounced than in the tail flick test. When doses of the three agents giving similar levels of antinociception were compared in a single group, the degree of inhibition of antinociception was comparable. Inhibition of the effect of noradrenaline was observed up to 14 days following pretreatment. The sensitivity of spinal antinociception to pertussis toxin suggests involvement of a guanine nucleotide regulatory protein in spinal actions of morphine, noradrenaline and L-baclofen. There is support in the literature for the additional involvement of adenylate cyclase in the action of morphine and noradrenaline but not of baclofen.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3350059</pmid><doi>10.1016/0014-2999(88)90487-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenylate Cyclase Toxin Analgesics - administration & dosage Analgesics - antagonists & inhibitors Animals Baclofen Baclofen - administration & dosage Baclofen - antagonists & inhibitors Biological and medical sciences Body Weight - drug effects Bordetella pertussis Fundamental and applied biological sciences. Psychology Injections, Spinal Male Morphine Morphine - administration & dosage Morphine - antagonists & inhibitors Noradrenaline Norepinephrine - administration & dosage Norepinephrine - antagonists & inhibitors Pertussis Toxin Rats Rats, Inbred Strains Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tail flick test Vertebrates: nervous system and sense organs Virulence Factors, Bordetella - pharmacology |
| title | Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen |
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