Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes

The effect of halothane on isoproterenol-stimulated lipolysis was determined in isolated rat epididymal fat cells. The maximal lipolytic response (Emax) activated by isoproterenol was 350 +/- 61 nmol of glycerol/10(5) cells/hr with an EC50 of 5.1 X 10(-9) M. When the adipocytes were simultaneously b...

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Veröffentlicht in:	Molecular pharmacology 1988-03, Vol.33 (3), p.338-343
Hauptverfasser:	PROKOCIMER, P. G, MAZE, M, VICKERY, R. G, KRAEMER, F. B, GANDJEI, R, HOFFMAN, B. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Calcium - metabolism Dose-Response Relationship, Drug Halothane - pharmacology In Vitro Techniques Isoproterenol - pharmacology Lipase - analysis Lipolysis - drug effects Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Protein Kinases - analysis Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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