Gemfibrozil treatment of endogenous hypertriglyceridemia : Effect of insulin-mediated glucose disposal and plasma insulin concentrations
Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein chole...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1996-07, Vol.81 (7), p.2550-2553 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | JENG, C.-Y SHEU, W. H.-H FUH, M. M.-T SHIEH, S.-M IDA CHEN, Y.-D REAVEN, G. M |
| description | Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein cholesterol concentrations increased (0.54 +/- 0.03 to 0.67 +/- 0.04 mmol/L; P < 0.001) in gemfibrozil-treated patients, associated with lower (P < 0.01-0.001) plasma free fatty acid and TG concentrations when measured at hourly intervals in response to breakfast (0800 h) and lunch (1200 h). However, day-long plasma glucose and insulin responses to meals in the 2 groups were similar before and after treatment, as were the steady state plasma glucose and insulin concentrations at the end of a 180-min infusion of somatostatin, insulin, and glucose. Thus, marked decreases in both plasma TG and free fatty acid concentrations seen in association with gemfibrozil neither enhanced insulin-mediated glucose disposal nor lowered ambient plasma insulin concentrations in patients with endogenous hypertriglyceridemia. |
| doi_str_mv | 10.1210/jc.81.7.2550 |
| format | Article |
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H.-H ; FUH, M. M.-T ; SHIEH, S.-M ; IDA CHEN, Y.-D ; REAVEN, G. M</creator><creatorcontrib>JENG, C.-Y ; SHEU, W. H.-H ; FUH, M. M.-T ; SHIEH, S.-M ; IDA CHEN, Y.-D ; REAVEN, G. M</creatorcontrib><description>Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein cholesterol concentrations increased (0.54 +/- 0.03 to 0.67 +/- 0.04 mmol/L; P < 0.001) in gemfibrozil-treated patients, associated with lower (P < 0.01-0.001) plasma free fatty acid and TG concentrations when measured at hourly intervals in response to breakfast (0800 h) and lunch (1200 h). However, day-long plasma glucose and insulin responses to meals in the 2 groups were similar before and after treatment, as were the steady state plasma glucose and insulin concentrations at the end of a 180-min infusion of somatostatin, insulin, and glucose. Thus, marked decreases in both plasma TG and free fatty acid concentrations seen in association with gemfibrozil neither enhanced insulin-mediated glucose disposal nor lowered ambient plasma insulin concentrations in patients with endogenous hypertriglyceridemia.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.81.7.2550</identifier><identifier>PMID: 8675576</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Glucose - metabolism ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesterol, VLDL - blood ; Circadian Rhythm ; Fatty Acids, Nonesterified - blood ; Gemfibrozil - therapeutic use ; General and cellular metabolism. Vitamins ; Humans ; Hypertriglyceridemia - blood ; Hypertriglyceridemia - complications ; Hypertriglyceridemia - drug therapy ; Hypolipidemic Agents - therapeutic use ; Insulin - blood ; Insulin Resistance ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Triglycerides - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 1996-07, Vol.81 (7), p.2550-2553</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-3e01ce637a600434c7139e830d70923baae0c9dd65b8f63bf776bbbfec930f333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3168055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8675576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JENG, C.-Y</creatorcontrib><creatorcontrib>SHEU, W. H.-H</creatorcontrib><creatorcontrib>FUH, M. M.-T</creatorcontrib><creatorcontrib>SHIEH, S.-M</creatorcontrib><creatorcontrib>IDA CHEN, Y.-D</creatorcontrib><creatorcontrib>REAVEN, G. M</creatorcontrib><title>Gemfibrozil treatment of endogenous hypertriglyceridemia : Effect of insulin-mediated glucose disposal and plasma insulin concentrations</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein cholesterol concentrations increased (0.54 +/- 0.03 to 0.67 +/- 0.04 mmol/L; P < 0.001) in gemfibrozil-treated patients, associated with lower (P < 0.01-0.001) plasma free fatty acid and TG concentrations when measured at hourly intervals in response to breakfast (0800 h) and lunch (1200 h). However, day-long plasma glucose and insulin responses to meals in the 2 groups were similar before and after treatment, as were the steady state plasma glucose and insulin concentrations at the end of a 180-min infusion of somatostatin, insulin, and glucose. Thus, marked decreases in both plasma TG and free fatty acid concentrations seen in association with gemfibrozil neither enhanced insulin-mediated glucose disposal nor lowered ambient plasma insulin concentrations in patients with endogenous hypertriglyceridemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>Circadian Rhythm</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Gemfibrozil - therapeutic use</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Hypertriglyceridemia - blood</subject><subject>Hypertriglyceridemia - complications</subject><subject>Hypertriglyceridemia - drug therapy</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Triglycerides - blood</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFu1DAQhi0EKkvhxhXJB8SJLHYc2wm3qioFqRIXkLhZE3u8eOXYwU4OyxPw2KR06WkO_6d_Zj5CXnO25y1nH4523_O93rdSsidkx4dONpoP-inZMdbyZtDtj-fkRa1HxnjXSXFBLnqlpdRqR_7c4uTDWPLvEOlSEJYJ00Kzp5hcPmDKa6U_TzOWpYRDPFksweEUgH6kN96j_ceGVNcYUjOhC7Cgo4e42lyRulDnXCFSSI7OEeoE_2Fqc7LbrgJLyKm-JM88xIqvzvOSfP908-36c3P39fbL9dVdYwWXSyOQcYtKaFCMdaKzmosBe8GcZkMrRgBkdnBOybH3SoxeazWO43boIJgXQlySdw-9c8m_VqyLmUK1GCMk3H41uued6rTcwPcPoC251oLezCVMUE6GM3Mv3hyt6bnR5l78hr85967jpuERPpve8rfnHKqF6AskG-ojJrjqmZTiL0L-jwc</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>JENG, C.-Y</creator><creator>SHEU, W. H.-H</creator><creator>FUH, M. M.-T</creator><creator>SHIEH, S.-M</creator><creator>IDA CHEN, Y.-D</creator><creator>REAVEN, G. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-3e01ce637a600434c7139e830d70923baae0c9dd65b8f63bf776bbbfec930f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>Circadian Rhythm</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Gemfibrozil - therapeutic use</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Hypertriglyceridemia - blood</topic><topic>Hypertriglyceridemia - complications</topic><topic>Hypertriglyceridemia - drug therapy</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JENG, C.-Y</creatorcontrib><creatorcontrib>SHEU, W. H.-H</creatorcontrib><creatorcontrib>FUH, M. M.-T</creatorcontrib><creatorcontrib>SHIEH, S.-M</creatorcontrib><creatorcontrib>IDA CHEN, Y.-D</creatorcontrib><creatorcontrib>REAVEN, G. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gemfibrozil treatment of endogenous hypertriglyceridemia : Effect of insulin-mediated glucose disposal and plasma insulin concentrations</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>81</volume><issue>7</issue><spage>2550</spage><epage>2553</epage><pages>2550-2553</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein cholesterol concentrations increased (0.54 +/- 0.03 to 0.67 +/- 0.04 mmol/L; P < 0.001) in gemfibrozil-treated patients, associated with lower (P < 0.01-0.001) plasma free fatty acid and TG concentrations when measured at hourly intervals in response to breakfast (0800 h) and lunch (1200 h). However, day-long plasma glucose and insulin responses to meals in the 2 groups were similar before and after treatment, as were the steady state plasma glucose and insulin concentrations at the end of a 180-min infusion of somatostatin, insulin, and glucose. Thus, marked decreases in both plasma TG and free fatty acid concentrations seen in association with gemfibrozil neither enhanced insulin-mediated glucose disposal nor lowered ambient plasma insulin concentrations in patients with endogenous hypertriglyceridemia.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>8675576</pmid><doi>10.1210/jc.81.7.2550</doi><tpages>4</tpages></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 1996-07, Vol.81 (7), p.2550-2553 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Blood Glucose - metabolism Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood Circadian Rhythm Fatty Acids, Nonesterified - blood Gemfibrozil - therapeutic use General and cellular metabolism. Vitamins Humans Hypertriglyceridemia - blood Hypertriglyceridemia - complications Hypertriglyceridemia - drug therapy Hypolipidemic Agents - therapeutic use Insulin - blood Insulin Resistance Medical sciences Middle Aged Pharmacology. Drug treatments Triglycerides - blood |
| title | Gemfibrozil treatment of endogenous hypertriglyceridemia : Effect of insulin-mediated glucose disposal and plasma insulin concentrations |
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